Additional file 1: Table S1. of Giardia-specific cellular immune responses in post-giardiasis chronic fatigue syndrome

Cultured PBMC supernatant analysis. Analyses of cytokines and soluble CD40L in supernatants of PBMC cultured for 6 days stimulated with Giardia lysates. (PDF 72 kb

Scatter plot comparing the New index (NoLI) with liver stiffness measured by transient elastography.

<p>The Spearman correlation coefficient was 0.542 (p<0.001).</p

Baseline characteristics in the (A) exploratory set and (B) the validation set according to presence of cirrhosis in liver biopsy.

<p>All values are presented as median (interquartile range; IQR) or percentage.</p>a<p>n = 28.</p>b<p>n = 166.</p>c<p>n = 6.</p>d<p>n = 60.</p

Baseline Characteristics with Patients Grouped According to HCV genotype and <i>IL28B</i> Genetic Variations (<i>rs12979860</i>).

<p>Data presented as median (25^th–75th percentile)^a or n^b.</p

Box-plots displaying the different components of the NoLI index (D₇ lathosterol, platelet count, Prothrombin complex-INR, age and BMI) and the NoLI index in relation to Ishak fibrosis stage.

<p>Box-plots displaying the different components of the NoLI index (D₇ lathosterol, platelet count, Prothrombin complex-INR, age and BMI) and the NoLI index in relation to Ishak fibrosis stage.</p

Receiver operator characteristics curves plotting sensitivity against specificity for prediction of cirrhosis in the exploratory set (n = 278) for the new index (NoLI) in comparison with some other biochemical indices.

<p>The AUROC for NoLI was 0.91 (95% CI 0.86–0.96). The corresponding AUROC for the other indices in the exploratory set were for FIB4 0.81 (95% CI 0.75–0.87), Lok 0.79 (95% CI 0.71–0.87), APRI 0.81 (95% CI 0.74–0.88), and for GUCI 0.81 (95% CI 0.74–0.88).</p

Impact of <i>IL28B</i> (<i>rs12979860</i>) on normalized ALT and AST to platelet ratio index (APRI) among HCV genotype 2 and 3 infected patients.

<p>Box plots displaying the 10^th, 25^th, 50^th, 75^th, and 90^th percentiles and p-values obtained using Kruskal-Wallis test.</p

Association between <i>IL28B</i> (<i>rs12979860</i>) and portal inflammation grade (Ishak protocol) and steatosis grade among HCV genotype 2 and 3 infected patients.

<p>Histogram displaying the proportion of patients, and p-value obtained using Chi-squared test.</p

Proportion of correct classifications (i.e. non-cirrhotic classified as non-cirrhotic and cirrhotic classified as cirrhotic) according to different cut-off levels for NoLI.

<p>The solid vertical lines represent the chosen cut-offs 0.054 and 0.37. Using these cut-offs, the misclassification error would be approximately 5% for cirrhotic as well as non-cirrhotic patients, respectively (dotted horizontal line).</p

Impact of <i>IL28B</i> (<i>rs12979860</i>) on baseline viral load and decline in mean HCV RNA day 0–3 among HCV genotype 2 and 3 infected patients.

<p>Box plots displaying the 10^th, 25^th, 50^th, 75^th, and 90^th percentiles, and p-values obtained using Kruskal-Wallis test.</p