Late glacial paleoceanography of Hinlopen Strait, northern Svalbard

Timing and structure of the Late and post-glacial development of the northern Svalbard margin, together with the initial influx of Atlantic water into the Arctic Ocean are still very poorly constrained. We investigated a sediment core (NP94-51) from a high accumulation area on the continental shelf north of Hinlopen Strait with the purpose of resolving the timing and structure of the last deglaciation. Detailed analyses of ice-rafted detritus, benthic and planktonic foraminiferal fauna, diatom flora, grain size and radiocarbon dates are used to reconstruct the palaeoceanographic evolution of the area. Our results indicate that the disintegration of Hinlopen Strait ice and possibly the northern margin of the Svalbard Ice Sheet commenced between 13.7 and 13.9 14C Ky BP. Influx of subsurface Atlantic waters into the area (12.6 14C Ky BP) and the retreat of the sea ice cover, with the accompanying opening of the surface waters (10.8 14C Ky BP), happened at different times and both much later than the disintegration of the ice sheets. The transition into the Holocene shows a two-step warming

Late glacial palaeoceanography of Hinlopen Strait, northern Svalbard

Timing and structure of the Late and post-glacial development of the northern Svalbard margin, together with the initial influx of Atlantic water into the Arctic Ocean are still very poorly constrained. We investigated a sediment core (NP94-51) from a high accumulation area on the continental shelf north of Hinlopen Strait with the purpose of resolving the timing and structure of the last deglaciation. Detailed analyses of ice-rafted detritus, benthic and planktonic foraminiferal fauna, diatom flora, grain size and radiocarbon dates are used to reconstruct the palaeoceanographic evolution of the area. Our results indicate that the disintegration of Hinlopen Strait ice and possibly the northern margin of the Svalbard Ice Sheet commenced between 13.7 and 13.9 14C Ky BP. Influx of subsurface Atlantic waters into the area (12.6 14C Ky BP) and the retreat of the sea ice cover, with the accompanying opening of the surface waters (10.8 14C Ky BP), happened at different times and both much later than the disintegration of the ice sheets. The transition into the Holocene shows a two-step warming

Extramedullary leukemia in children with acute myeloid leukemia: A population-based cohort study from the Nordic Society of Pediatric Hematology and Oncology (NOPHO).

To access publisher's full text version of this article click on the hyperlink belowThe prognostic significance of extramedullary leukemia (EML) in childhood acute myeloid leukemia is not clarified.This population-based study included 315 children from the NOPHO-AML 2004 trial.At diagnosis, 73 (23%) patients had EML: 39 (12%) had myeloid sarcoma, 22 (7%) had central nervous system disease, and 12 (4%) had both. EML was associated with young age (median age: 2.6 years), a high white blood cell count (median: 40 × 10(9) /l), M5 morphology (40%), and 11q23/MLL (KMT2A) rearrangements (34%). No patient received involved field radiotherapy. Five-year event-free survival did not differ significantly between the EML and the non-EML patients (54% vs. 45%, P = 0.57), whereas 5-year overall survival (OS) was significantly lower in the EML group (64% vs. 73%, P = 0.04). The risk of induction death was significantly higher for EML patients (8% vs. 1%, P = 0.002). There was a trend toward a lower risk of relapse for EML patients (5-year cumulative incidence of relapse 33% vs. 49%, P = 0.16). Traumatic lumbar puncture did not adversely affect survival in this cohort.EML was associated with increased risk of induction death impacting the OS. No patients relapsed at the primary site of the myeloid sarcoma despite management without radiotherapy.Danish Cancer Society Department of Clinical Medicine at Aarhus University Danish Childhood Cancer Foundation Swedish Childhood Cancer Foundatio