Comparison of hazard ratios (HR) with 95% confidence intervals (CI) for all-cause, cardiovascular and coronary mortality among non-diabetic women with history of CVD and diabetic women without CVD (N = 942).

*<p>p<0.05 for comparison with the no diabetes with CVD group.</p><p>Women with no diabetes and history of CVD were used as the reference group.</p>a<p>Late onset diabetes defined as having diabetes since 10 years or less.</p>b<p>Long-term diabetes defined as having diabetes since more than 10 years.</p>c<p>Adjusted for age, smoking status, physical activity, systolic blood pressure, body mass index and education.</p><p>Abbreviations: CVD, cardiovascular disease.</p

Survival curves according to the presence of diabetes or history of cardiovascular disease (CVD).

<p>a: Total mortality. b: Cardiovascular disease mortality. c: Coronary heart disease (CHD) mortality.</p

Characteristics of older women by presence or absence of diabetes and cardiovascular disease (CVD^a) (N = 9218).

<p>Values are mean ± standard deviation (SD) or percentages.</p>*<p>p<0.05,</p>**<p>p<0.005 for pairwise comparison with no diabetes and no CVD category.</p><p>p values were based on t-tests and chi-square tests for trend for multilevel categorical variables.</p>a<p>CVD was defined as myocardial infarction or stroke.</p>b<p>Former smoking was defined as at least 100 cigarettes for the all life. Chi-square tests for trend.</p>c<p>Physical activity expressed as median [25%–75%] and Mann-Whitney rank sum test performed.</p

Incidence and hazard ratios (HR) with 95% confidence intervals (CI) for all-cause, cardiovascular and coronary mortality (N = 9218).

<p>Women with no diabetes and no history of CVD were used as the reference group.</p>*<p>p<0.001 for comparison with the no diabetes and no CVD group. p values were based on log-rank tests for the rates of death and Wald test from the Cox model for other variables.</p>a<p>Adjusted for age, smoking status, physical activity, systolic blood pressure, body mass index and education.</p><p>Abbreviations: CVD, cardiovascular disease.</p

Associations of additional predictor covariates with total health care costs for 1 year after SOF year 10 exam, adjusted only for base model covariates^*^†.

<p>Associations of additional predictor covariates with total health care costs for 1 year after SOF year 10 exam, adjusted only for base model covariates^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0191642#t004fn001" target="_blank">*</a>}^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0191642#t004fn002" target="_blank">†</a>}.</p

Associations of weight change and BMI with total health care costs, outpatient costs, hospital stays, and SNF stays (base model without interaction terms)^*^{^}.

<p>Associations of weight change and BMI with total health care costs, outpatient costs, hospital stays, and SNF stays (base model without interaction terms)^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0191642#t003fn001" target="_blank">*</a>}^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0191642#t003fn002" target="_blank">^</a>}.</p

Flow diagram of analysis cohort.

<p>Flow diagram of analysis cohort.</p

Distribution of study population characteristics at SOF year 10 exam.

<p>Distribution of study population characteristics at SOF year 10 exam.</p

Characteristics of 4605 women and according to enrollment and BMI status^*.

<p>Characteristics of 4605 women and according to enrollment and BMI status^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0191642#t002fn001" target="_blank">*</a>}.</p

Characteristics of MrOS participants with PSG sleep staging and <i>APOE</i> genotyping.

<p>Characteristics of MrOS participants with PSG sleep staging and <i>APOE</i> genotyping.</p