Remodeling of extra-bronchial lung vasculature following allergic airway inflammation-1

<p><b>Copyright information:</b></p><p>Taken from "Remodeling of extra-bronchial lung vasculature following allergic airway inflammation"</p><p>http://respiratory-research.com/content/9/1/18</p><p>Respiratory Research 2008;9(1):18-18.</p><p>Published online 8 Feb 2008</p><p>PMCID:PMC2254605.</p><p></p> approximately 5 times and in mid-sized approximately 3 times. Smooth muscle was detected by labelling with α-smooth muscle actin, and the positively stained area measured by digital image analysis and correlated to the length of the basement membrane (BM). The data are given as mean ± SEM and compared against control using the Wilcoxon Signed-ranks test, * indicates p < 0.05

Remodeling of extra-bronchial lung vasculature following allergic airway inflammation-2

<p><b>Copyright information:</b></p><p>Taken from "Remodeling of extra-bronchial lung vasculature following allergic airway inflammation"</p><p>http://respiratory-research.com/content/9/1/18</p><p>Respiratory Research 2008;9(1):18-18.</p><p>Published online 8 Feb 2008</p><p>PMCID:PMC2254605.</p><p></p>(procollagen I: brown) and myofibroblasts (here defined as solitary cells co-positive for α-smooth muscle actin and procollagen I: co-positive), in both small solitary (A-B) and mid-sized solitary (C-D) vessels. In comparison with controls (A and C) vessels from OVA exposed animals (B and D) show a significantly increased smooth muscle area as well as increased number of myofibroblasts (arrows) and procollagen I-producing cells. Vascular lumen is indicated by stars. Scale bar represents 50 μm

Remodeling of extra-bronchial lung vasculature following allergic airway inflammation-0

<p><b>Copyright information:</b></p><p>Taken from "Remodeling of extra-bronchial lung vasculature following allergic airway inflammation"</p><p>http://respiratory-research.com/content/9/1/18</p><p>Respiratory Research 2008;9(1):18-18.</p><p>Published online 8 Feb 2008</p><p>PMCID:PMC2254605.</p><p></p>reased following allergen challenge. Proliferation was detected using the proliferation-marker Ki67. A base line proliferation was present also in controls, however the number was very low and when correlated to the length of the basement membrane (BM), the values closed in on zero. The data are given as mean ± SEM and compared against control using the Wilcoxon Signed-ranks test, * indicates p < 0.05

Remodeling of extra-bronchial lung vasculature following allergic airway inflammation-3

<p><b>Copyright information:</b></p><p>Taken from "Remodeling of extra-bronchial lung vasculature following allergic airway inflammation"</p><p>http://respiratory-research.com/content/9/1/18</p><p>Respiratory Research 2008;9(1):18-18.</p><p>Published online 8 Feb 2008</p><p>PMCID:PMC2254605.</p><p></p>le actin and procollagen I) increased significantly following allergen exposure. Occasional smooth muscle cells may produce procollagen I; however smooth muscle cells are not normally solitary. Sporadic myofibroblasts were also visible before allergen challenge, but when correlated to the length of the basement membrane (BM) the values are very small and closed in on zero. The data are given as mean ± SEM and compared against control using the Wilcoxon Signed-ranks test, * indicates p < 0.05