Additional file 1: Figure S1. of ANLN is a prognostic biomarker independent of Ki-67 and essential for cell cycle progression in primary breast cancer

Distribution of ANLN nuclear fraction with regard to tamoxifen treatment. Distribution of ANLN nuclear fraction was analyzed with regard to tamoxifen treatment in cohort II, a randomized prospective tamoxifen trial. The distribution of ANLN nuclear fraction was similar in the treatment and control arms with the majority of tumors expressing less than 25% of ANLN nuclear staining. (PDF 25 kb

Additional file 5: Figure S5. of ANLN is a prognostic biomarker independent of Ki-67 and essential for cell cycle progression in primary breast cancer

Association of ANLN expression with senescence. Transient knockdown of ANLN expression induced significant levels of cellular senescence compared to controls in SKBR3 cells up to 5 days after initiation of ANLN depletion. Significant levels of cellular senescence compared to controls were noted in T47D cells 5 days after ANLN siRNA knockdown. Similar, but not significant, result was observed 3 days after knockdown. Scale bars 60 μm. (TIF 14662 kb