THE MEANING OF RUNNING IN AMERICAN SOCIETY

Most media resources, medical associations, articles of popular culture, and sports-related companies promote running as an activity that builds self-esteem and supports general physical and mental health. This paper delves into the connection between running and the characteristics of our society. The analysis examines the meaning of running, as a symbol of our society that perpetuates ideals of corporatization, consumerism, capitalism, and gender stereotypes. Additionally, this paper examines the ways running is perceived and participated in; and how they have changed overtime, alongside political, economic, and historical events

Mapping Ohio's Compassion

This report gives an overview of the state of the nonprofit sector in Ohio

Too early for early education? Effects on parenting for mothers and fathers

Objective: To estimate the effect of children's age of entry into early childhood education and care (ECEC) on parenting quality of mothers and fathers in a context of universal access to subsidized ECEC following a 1 year paid parental leave. Background: Children entering non-parental care settings in early childhood may have negative consequences for parenting quality. Yet, current evidence supporting this claim is predominantly from the United States, is focused almost exclusively on mothers, and is predominantly based on statistical approaches that are vulnerable to unobserved selection bias. Method: Data are from a Norwegian longitudinal study, including ratings of observed mother–child (n = 901) and father–child (n = 621) interactions, and children's age of entry into ECEC. Multivariate regression models and instrumental variable models were used to estimate the causal effect of age of entry on parenting quality. Results: There was no support for the hypothesis that an earlier age of entry into ECEC negatively affects parenting quality, for either fathers or mothers. This was true for the sample as a whole, and for different sociodemographic subgroups. Conclusion: In a Norwegian context in which families have universal access to subsidized ECEC from the time their child is 1 year of age, and most children enter ECEC in their second year, there is no evidence that an earlier age of entry in ECEC harms parenting quality.info:eu-repo/semantics/publishedVersio

Dynamics and diversity of bacteria associated with the disease vectors Aedes aegypti and Aedes albopictus

Aedes aegypti and Aedes albopictus develop in the same aquatic sites where they encounter microorganisms that infuence their life history and capacity to transmit human arboviruses. Some bacteria such as Wolbachia are currently being considered for the control of Dengue, Chikungunya and Zika. Yet little is known about the dynamics and diversity of Aedes-associated bacteria, including larval habitat features that shape their tempo-spatial distribution. We applied large-scale 16S rRNA amplicon sequencing to 960 adults and larvae of both Ae. aegypti and Ae. albopictus mosquitoes from 59 sampling sites widely distributed across nine provinces of Panama. We fnd both species share a limited, yet highly variable core microbiota, refecting high stochasticity within their oviposition habitats. Despite sharing a large proportion of microbiota, Ae. aegypti harbours higher bacterial diversity than Ae. albopictus, primarily due to rarer bacterial groups at the larval stage. We fnd signifcant diferences between the bacterial communities of larvae and adult mosquitoes, and among samples from metal and ceramic containers. However, we fnd little support for geography, water temperature and pH as predictors of bacterial associates. We report a low incidence of natural Wolbachia infection for both Aedes and its geographical distribution. This baseline information provides a foundation for studies on the functions and interactions of Aedes-associated bacteria with consequences for bio-control within Panama.Aedes aegypti and Aedes albopictus develop in the same aquatic sites where they encounter microorganisms that infuence their life history and capacity to transmit human arboviruses. Some bacteria such as Wolbachia are currently being considered for the control of Dengue, Chikungunya and Zika. Yet little is known about the dynamics and diversity of Aedes-associated bacteria, including larval habitat features that shape their tempo-spatial distribution. We applied large-scale 16S rRNA amplicon sequencing to 960 adults and larvae of both Ae. aegypti and Ae. albopictus mosquitoes from 59 sampling sites widely distributed across nine provinces of Panama. We fnd both species share a limited, yet highly variable core microbiota, refecting high stochasticity within their oviposition habitats. Despite sharing a large proportion of microbiota, Ae. aegypti harbours higher bacterial diversity than Ae. albopictus, primarily due to rarer bacterial groups at the larval stage. We fnd signifcant diferences between the bacterial communities of larvae and adult mosquitoes, and among samples from metal and ceramic containers. However, we fnd little support for geography, water temperature and pH as predictors of bacterial associates. We report a low incidence of natural Wolbachia infection for both Aedes and its geographical distribution. This baseline information provides a foundation for studies on the functions and interactions of Aedes-associated bacteria with consequences for bio-control within Panama

Safety in Numbers: Pedestrian and Bicyclist Activity and Safety in Minneapolis

This investigation aims to evaluate whether the Safety in Numbers phenomenon is observable in the midwestern U.S. city of Minneapolis, Minnesota. Safety in Numbers (SIN) refers to the phenomenon that pedestrian safety is positively correlated with increased pedestrian traffic in a given area. Walking and bicycling are increasingly becoming important transportation modes in modern cities. Proper placement of non-motorized facilities and improvements has implications for safety, accessibility, and mode choice, but proper information regarding estimated non-motorized traffic levels is needed to locate areas where investments can have the greatest impact. Assessment of collision risk between automobiles and non-motorized travelers offers a tool that can help inform investments to improve non-motorized traveler safety. Models of non-motorized crash risk typically require detailed historical multimodal crash and traffic volume data, but many cities do not have dense datasets of non-motorized transport flow levels. Methods of estimating pedestrian and bicycle behavior that do not rely heavily on high-resolution count data are applied in this study. Pedestrian and cyclist traffic counts, average automobile traffic, and crash data from the city of Minneapolis are used to build models of crash frequencies at the intersection level as a function of modal traffic inputs. These models determine whether the SIN effect is observable within the available datasets for pedestrians, cyclists, and cars, as well as determine specific locations within Minneapolis where non-motorized travelers experience elevated levels of risk of crashes with automobiles

IP-10/CXCL10 induction in human pancreatic cancer stroma influences lymphocytes recruitment and correlates with poor survival

Pancreatic ductal adenocarcinoma (PDAC) is characterized by an abundant desmoplastic reaction driven by pancreatic stellate cells (PSCs) that contributes to tumor progression. Here we sought to characterize the interactions between pancreatic cancer cells (PCCs) and PSCs that affect the inflammatory and immune response in pancreatic tumors. Conditioned media from mono- and cocultures of PSCs and PCCs were assayed for expression of cytokines and growth factors. IP-10/CXCL10 was the most highly induced chemokine in coculture of PSCs and PCCs. Its expression was induced in the PSCs by PCCs. IP-10 was elevated in human PDAC specimens, and positively correlated with high stroma content. Furthermore, gene expression of IP-10 and its receptor CXCR3 were significantly associated with the intratumoral presence of regulatory T cells (Tregs). In an independent cohort of 48 patients with resectable pancreatic ductal adenocarcinoma, high IP-10 expression levels correlated with decreased median overall survival. Finally, IP-10 stimulated the ex vivo recruitment of CXCR3+ effector T cells as well as CXCR3+ Tregs derived from patients with PDAC. Our findings suggest that, in pancreatic cancer, CXCR3+ Tregs can be recruited by IP-10 expressed by PSCs in the tumor stroma, leading to immunosuppressive and tumor-promoting effects

Safety in Numbers and Safety in Congestion for Bicyclists and Motorists at Urban Intersections

This study assesses the estimated crashes per bicyclist and per vehicle as a function of bicyclist and vehicle traffic, and tests whether greater traffic reduces the per-car crash rate. We present a framework for comprehensive bicyclist risk assessment modeling, using estimated bicyclist flow per intersection, observed vehicle flow, and crash records. Using a two-part model of crashes, we reveal that both the annual average daily traffic and daily bicyclist traffic have a diminishing return to scale in crashes. This accentuates the positive role of safety in numbers. Increasing the number of vehicles and cyclists decelerates not only the probability of crashes, but the number of crashes as well. Measuring the elasticity of the variables, it is found that a 1% increase in the annual average daily motor vehicle traffic increases the probability of crashes by 0.14% and the number of crashes by 0.80%. However, a 1% increase in the average daily bicyclist traffic increases the probability of crashes by 0.09% and the number of crashes by 0.50%. The saturation point of the safety in numbers for bicyclists is notably less than for motor vehicles. Extracting the vertex point of the parabola functions examines that the number of crashes starts decreasing when daily vehicle and bicyclist traffic per intersection exceed 29,568 and 1,532, respectively.Road Safety Institut

Poly(Limonene Thioether) Scaffold for Tissue Engineering

A photocurable thiol-ene network polymer, poly(limonene thioether) (PLT32o), is synthesized, characterized, fabricated into tissue engineering scaffolds, and demonstrated in vitro and in vivo. Micromolded PLT32o grids exhibit compliant, elastomeric mechanical behavior similar to grids made of poly(glycerol sebacate) (PGS), an established biomaterial. Multilayered PL32o scaffolds with regular, geometrically defined pore architectures support heart cell seeding and culture in a manner similar to multilayered PGS scaffolds. Subcutaneous implantation of multilayered PLT32o scaffolds with cultured heart cells provides long-term 3D structural support and retains the exogenous cells, whereas PGS scaffolds lose both their structural integrity and the exogenous cells over 31 d in vivo. PLT32o membrane implants retain their dry mass, whereas PGS implants lose 70 percent of their dry mass by day 31. Macrophages are initially recruited to PLT32o and PGS membrane implants but are no longer present by day 31. Facile synthesis and processing in combination with the capability to support heart cells in vitro and in vivo suggest that PLT32o can offer advantages for tissue engineering applications where prolonged in vivo maintenance of 3D structural integrity and elastomeric mechanical behavior are required.United States. National Institutes of Health (R01-HL107503

Habitat disturbance and the organization of bacterial communities in Neotropical hematophagous arthropods

The microbiome plays a key role in the biology, ecology and evolution of arthropod vectors of human pathogens. Vector-bacterial interactions could alter disease transmission dynamics through modulating pathogen replication and/or vector fitness. Nonetheless, our understanding of the factors shaping the bacterial community in arthropod vectors is incomplete. Using large-scale 16S amplicon sequencing, we examine how habitat disturbance structures the bacterial assemblages of field-collected whole-body hematophagous arthropods that vector human pathogens including mosquitoes (Culicidae), sand flies (Psychodidae), biting midges (Ceratopogonidae) and hard ticks (Ixodidae). We found that all comparisons of the bacterial community among species yielded statistically significant differences, but a difference was not observed between adults and nymphs of the hard tick, Haemaphysalis juxtakochi. While Culicoides species had the most distinct bacterial community among dipterans, tick species were composed of entirely different bacterial OTU’s. We observed differences in the proportions of some bacterial types between pristine and disturbed habitats for Coquillettidia mosquitoes, Culex mosquitoes, and Lutzomyia sand flies, but their associations differed within and among arthropod assemblages. In contrast, habitat quality was a poor predictor of differences in bacterial classes for Culicoides biting midges and hard tick species. In general, similarities in the bacterial communities among hematophagous arthropods could be explained by their phylogenetic relatedness, although intraspecific variation seems influenced by habitat disturbance.The microbiome plays a key role in the biology, ecology and evolution of arthropod vectors of human pathogens. Vector-bacterial interactions could alter disease transmission dynamics through modulating pathogen replication and/or vector fitness. Nonetheless, our understanding of the factors shaping the bacterial community in arthropod vectors is incomplete. Using large-scale 16S amplicon sequencing, we examine how habitat disturbance structures the bacterial assemblages of field-collected whole-body hematophagous arthropods that vector human pathogens including mosquitoes (Culicidae), sand flies (Psychodidae), biting midges (Ceratopogonidae) and hard ticks (Ixodidae). We found that all comparisons of the bacterial community among species yielded statistically significant differences, but a difference was not observed between adults and nymphs of the hard tick, Haemaphysalis juxtakochi. While Culicoides species had the most distinct bacterial community among dipterans, tick species were composed of entirely different bacterial OTU’s. We observed differences in the proportions of some bacterial types between pristine and disturbed habitats for Coquillettidia mosquitoes, Culex mosquitoes, and Lutzomyia sand flies, but their associations differed within and among arthropod assemblages. In contrast, habitat quality was a poor predictor of differences in bacterial classes for Culicoides biting midges and hard tick species. In general, similarities in the bacterial communities among hematophagous arthropods could be explained by their phylogenetic relatedness, although intraspecific variation seems influenced by habitat disturbance