The Role of Anorexia in Resistance and Tolerance to Infections in Drosophila

Infections initiate a signaling loop in which sick animals become anorexic, and the resulting change in diet alters the body's ability to fight infections in good and bad ways

Universal entanglement and boundary geometry in conformal field theory

Employing a conformal map to hyperbolic space cross a circle, we compute the universal contribution to the vacuum entanglement entropy (EE) across a sphere in even-dimensional conformal field theory. Previous attempts to derive the EE in this way were hindered by a lack of knowledge of the appropriate boundary terms in the trace anomaly. In this paper we show that the universal part of the EE can be treated as a purely boundary effect. As a byproduct of our computation, we derive an explicit form for the A-type anomaly contribution to the Wess-Zumino term for the trace anomaly, now including boundary terms. In d=4 and 6, these boundary terms generalize earlier bulk actions derived in the literature.Comment: 35 pages text plus 17 pages appendices and references, 3 figures; v2 package conflict resolved; v3 refs added, claim regarding newness of boundary central charge in d=4 removed, factor of 3 typo fixe

The outcome of acute schistosomiasis infection in adult mice with postnatal exposure to maternal malnutrition

Maternal malnutrition during the lactation period in early development may have long-term programming effects on adult offspring. We evaluated the combined effects of parasitological behaviour and histopathological features and malnutrition during lactation. Lactating mice and their pups were divided into a control group (fed a normal diet of 23% protein), a protein-restricted group (PR) (fed a diet containing 8% protein) and a caloric-restricted group (CR) (fed according to the PR group intake). At the age of 60 days, the offspring were infected with Schistosoma mansoni cercariae and killed at nine weeks post-infection. Food intake, body and liver masses, leptinaemia, corticosteronaemia, collagen morphometry and neogenesis and the cellular composition of liver granulomas were studied. PR offspring showed reduced weight gain and hypophagia, whereas CR offspring became overweight and developed hyperphagia. The pre-patent period was longer (45 days) in both programmed offspring as compared to controls (40 days). The PR-infected group had higher faecal and intestinal egg output and increased liver damage. The CR-infected group showed a lower number of liver granulomas, increased collagen neogenesis and a higher frequency of binucleate hepatocytes, suggesting a better modulation of the inflammatory response and increased liver regeneration. Taken together, our findings suggest that neonatal malnutrition of offspring during lactation affects the outcome of schistosomiasis in mice