One-pot synthesis of bis (phenylimino dihydro thiazolyl-2<i>H</i>-chromene) derivatives

<p>A novel series of bis (phenylimino dihydro thiazolyl-2<i>H</i>-chromene) derivatives have been synthesized through an efficient one-pot multicomponent approach involving different substituted of 3-(2-bromoacetyl)-2<i>H</i>-chromen-2-ones, phenyl isothiocyanates and <i>para</i>-phenylenediamine in presence of dimethylformamide solvent. The target compounds were obtained in a shorter reaction time through simple reaction work up with good yields. All the synthesized products were characterized by their spectral and analytical data like IR, ¹H NMR, ¹³C NMR, Roesy, and mass spectral data.</p

Facile one pot multicomponent synthesis of novel 4-(benzofuran-2-yl)-2-(3-(aryl/heteryl)-5-(aryl/heteryl)-4,5-dihydro-1<i>H</i>-pyrazol-1yl)thiazole derivatives

<p>An efficient base catalyzed one pot multicomponent reaction of aryl/hetryl chalcones, thiosemicarbazide and 1-(benzofuran-2-yl)-2-bromoethan-1-one was developed to synthesize the novel 4-(benzofuran-2-yl)-2-(3-(aryl/heteryl)-5-(aryl/heteryl)-4,5-dihydro-1<i>H</i>-pyrazol-1yl)thiazole derivatives.</p

Novel multicomponent synthesis of 2-OXO-1, 2-diphenylethylidene hydrazinyl thiadiazinyl-2<i>H</i>-chromen-2-one derivatives

<p></p> <p>A series of novel 2-oxo-1,2-diphenylethylidene hydrazinyl thiadiazinyl-2<i>H</i>-chromen-2-ones (shown in <a href="#c0001" target="_blank">Scheme 1</a>) have been synthesized via multicomponent approach by the reaction of equimolar amount of benzil (1), thiocarobohydrazide (2), and substituted of 3-(2-bromoacetyl)-2<i>H</i>-chromen-2-ones (3a-i) in a shorter reaction time with good yields. All these compounds were characterized by their spectral and analytical data like IR, ¹H NMR, ¹³C NMR, and mass spectra.</p

One-pot multicomponent synthesis of functionalized 2,5-disubstituted-1,3,4-thiadiazine derivatives

<p>An atom-efficient and environmentally friendly approach to the synthesis of 2,5-disubstituted-1,3,4-thidiazine derivatives has been developed. These compounds were synthesized by a reaction of 2-(2-bromoacetyl)benzofuran and thiocarbohydrazide with various aryl aldehydes, acetylacetones, and pthalic anhydrides in good yields. The advantages of this methodology are mild reaction conditions, easy workup procedure, clean reaction profile, shorter reaction time, and a wide range of substrate applicability. The structures of all synthesized compounds were confirmed from their analytical and spectral data.</p

Bis coumarinyl bis triazolothiadiazinyl ethane derivatives: Synthesis, antiviral activity evaluation, and molecular docking studies

<p>A series of novel 3,3′-(3,3′-(dihydroxy/hydroxyethane-1,2-diyl)bis(7<i>H</i>-[1,2,4]triazolo[3,4-<i>b</i>][1,3,4]thiadiazine-6,3-diyl))bis(2<i>H</i>-chromen-2-ones) were prepared by the condensation of thiocarbohydrazide with tartaric acid or malic acid followed by various 3-(2-bromoacetyl)-2<i>H</i>-chromen-2-ones in two steps with good yields. All the synthesized compounds were characterized by analytical and spectral (IR, ¹H NMR, ¹³C NMR, and mass) data. These synthesized bis(triazolothiadiazinyl coumarin) compounds were evaluated for broad spectrum of antiviral activity. Among all the tested compounds, compound <b>5f</b> exhibited antiviral activity against H1N1 virus. The molecular docking studies of these compounds against H1N1 neuraminidase enzyme were performed. The binding affinity and binding values were compared with standard drugs.</p