Corrosion behaviour of carbon steel in DTPMP inhibited neutral medium

106-108Corrosion rate for mild steel in neutral medium (model water) has been studied using a new voltammetric procedure. The synergistic effect of Zn++ ion with DTPMP inhibitor has revealed favourable results. Corrosion rate has been determined as a function of time, using gravimetric and electrochemical methods. The corrosion inhibition efficiency of DTPMP+Zn is fund to be 80% after 24 h

Corrosion rate determination at short time intervals: A new voltammetric method

398-401The variation of metal corrodibility, solution corrosiveness and corrosion rates for mild steel in 1 N H2SO4 acid, as a function of time have been studied using gravimetric (planned interval test) and electochemical methods. A new voltammetric method has been developed to determine the corrosion rates at short time intervals. The results of the corrosion of mild steel in 1 N H2SO4 with and without polyvinyl glycol (PVG) inhibitor at short time intervals have been reported. The corrosion inhibition efficiency of PVG is 91 % after 24 h. Significantly, it has also been possible to determine simultaneously the corrosion rates with respect to Fe(II) and Fe(III).</span

Role of bio-metal Fe(III) in anticancer behaviour of tamoxifen

429-433Physicochemical, microbial and pharmacological studies on Fe (III) - Tamoxifen complex have been carried out in solid and aqueous phases. On the basis of elemental analysis, polarographic studies, amperometric titrations and IR spectral studies the probable formula for the complex has been worked out to be 1:1, Fe(III) - Tamoxifen. A tentative structure has been suggested to the complex. The metal ligand interaction has been studied using polarographic method at 27° ± 1°C and at ionic strength of μ = 1.0 (KCl). Microbial studies on the complex was carried out against various pathogenic bacteria and fungi using Raper's method. Mouse sarcoma cell line 180 and Balb/C mice were used for the anticancer screening of solid compex, in vitro and in vivo, respectively. The results of microbial and pharmacological studies with the M:Drug complex revealed that the complex is more potent as compared to the pure drug as regards to its anticancer activity. As such Fe (III) Tamoxifen complex may be recommended to the therapeutic experts for its possible use as more potent anticancer drug

Voltammetric study of ds-DNA–flutamide interaction at carbon paste electrode

Differential pulse voltammetry (DPV) has been used to develop an electro-analytical procedure for the determination of flutamide and evaluate its interaction with DNA immobilised on the carbon paste electrode (CPE) surface. In 0.3 M phosphate buffer (pH 7.0 ± 0.01) as supporting electrolyte flutamide produced a well defined DPV peak at Ep = −0.75 V vs. SCE. The DPV study on the DNA–flutamide interaction clearly demonstrated that flutamide interacts preferentially with adenine and guanine groups in DNA. Thus, enabling to assign mechanism of action of the anticancer drug, flutamide. The developed method was successfully applied to the determination of flutamide in pharmaceutical formulations. The work has been supplemented by UV spectral study

Evaluation of antioxidant activity of crocin, podophyllotoxin and kaempferol by chemical, biochemical and electrochemical assays

The present study was designed to evaluate the antioxidant potential of three natural origin drugs, namely crocin, kaempferol and podophyllotoxin by chemical, biochemical and electrochemical assays. The chemical assay was carried out by DPPH and reducing power assays while the biochemical assay evaluated the lipid peroxidation inhibition capacity, using brain cells as models; the electrochemical characterization was performed by cyclic voltammetry and differential pulse voltammetry using multi-walled carbon nanotube paste electrode (MWCNTPE) in 0.02 M acetate buffer (pH 4.5). The superoxide radical scavenging activity was performed at dropping mercury electrode (DME) in 0.1 M KCl. All the species proved to have antioxidant activity, and particularly, by the electrochemical techniques, it has been shown that these drugs showed scavenging ability on superoxide anion produced by electrochemical reduction of oxygen. The highest scavenging property of crocin may be due to the hydroxyl and glucose moieties that could provide the necessary component as a radical scavenger