3 research outputs found
Antiepileptic potential of <i style="mso-bidi-font-style:normal">Anisomeles indica </i>(Linn.)<i style="mso-bidi-font-style:normal"> </i>Kuntze aerial parts in pentylenetetrazole-induced experimental convulsions in Wistar rats
715-720The chloroform
(4.20% w/w), ethyl acetate (4.23% w/w) and aqueous decoction (12.11% w/w) extracts
of the aerial parts of A. indica were
screened for the antiepileptic activity against maximal electroshock (MES)
model and pentylenetetrazole (PTZ) models at
doses of 200, 400 mg/kg, po once. Phenytoin and diazepam (25 and 2
mg/kg, ip) were used as standard
drugs in MES and PTZ model, respectively. Further, ethyl acetate extract
(active extract) was fractionated into flavonoid and tannin fraction, which
were subsequently evaluated for the antiepileptic potential against both MES
and PTZ models at a dose of 50 mg/kg, po.
Pretreatment with ethyl acetate extract 200, 400 mg/kg, po, for 1 week
showed significant antiepileptic activity against PTZ induced convulsions only.
Isolated flavonoid fraction showed more potent antiepileptic activity as
compared to ethyl acetate extract, without any neurotoxic effect. However,
tannin fraction did not produce antiepileptic activity against PTZ induced
convulsions. It may be concluded that the flavonoids fraction of ethyl acetate
extract of aerial parts of A. indica,
but not the aqueous decoction has antiepileptic potential, without producing
neurotoxic effects