Fig 2 -

Kaplan Meier Curves in a) IPTW adjusted (for confounding only) cohort of second-line patients b) IPTW and IOPW adjusted (for both confounding and non-representativeness) cohort of first-line patients. Time is shown in days. Note that sample size was impacted by weighting in our analyses.</p

Baseline characteristics before and after inverse probability of selection weighting (IOPW).

Baseline characteristics before and after inverse probability of selection weighting (IOPW).</p

Baseline characteristics before and after inverse probability of treatment weighting (IPTW) among the second-line population.

Baseline characteristics before and after inverse probability of treatment weighting (IPTW) among the second-line population.</p

Comparison of variables involved in Step 1 and Step 2 analyses.

Comparison of variables involved in Step 1 and Step 2 analyses.</p

Directed acyclic graph to illustrate our two-step approach to adjust for confounding with inverse probability of weighting (IPTW) and non-representativeness with inverse probability of selection weighting (IOPW).

A = treatment assignment; Y = outcome; S = selection into original population from target population; C = confounders; E = treatment effect modifiers.</p