(A) Lymphocytes present as part of oCPI-related CD.

<p>(B) These lymphocytes express PAX5 consistent with B cells. (C) Immunostaining for markers of immature B cells, including TdT as shown here, are negative. All original magnifications 400x.</p

Immunohistochemical subtyping of oCPI placenta demonstrates an IgG, IgA, and IgM expressing plasma cells (top row, original magnification 200x).

<p>In cases of isolated chronic deciduitis (chronic deciduitis without histological evidence of VUE and chronic chorioamnionitis), IgG-positive plasma cells predominate, IgM-positive plasma cells are rare, and IgA-positive plasma cells are not seen (bottom row, original magnification 200x).</p

Unsupervised hierarchical clustering, using the 1446 probes with suggestive differential expression (P-value < 0.05) between oCPI samples and controls, demonstrates complete separation of the two groups.

<p>Unsupervised hierarchical clustering, using the 1446 probes with suggestive differential expression (P-value < 0.05) between oCPI samples and controls, demonstrates complete separation of the two groups.</p

Volcano plot of expression association with oCPI.

<p>Each dot represents one of the 21 172 probes. The x-axis represents the effect of each gene, reported as log2 fold change, while the y-axis represents the –log10 (P-value). A positive log2 fold change is indicative of increased expression in oCPI samples as compared to controls. The red dots highlight the 14 genes with significant differential expression (FDR P-value < 0.05).</p

Proportions of IgA, IgM, and IgG expressing plasma cells in oCPI-related CD compared to isolated CD.

<p>Error bars represent the 95% confidence interval of the mean.</p

RNA transcripts significantly associated with oCPI.

<p>14 differentially expressed transcripts were identified using linear models (FDR P-value<0.05). A positive fold change indicates increased expression in oCPI samples as compared to controls.</p

(A) Boxplots of raw microarray intensity values demonstrate little variation between samples.

<p>(B) Multidimensional scaling (MDS) plot of raw intensity values, which visualizes the similarity between samples and demonstrates separation between the oCPI and control samples.</p

(A) Immunostaining for IgJ demonstrates reactivity in plasma cells in areas of chronic villitis and (B) chronic deciduitis (original magnifications 200x).

<p>(C) Very rare lymphocytic-appearing cells expressing IgJ were also seen (original magnification 400x). (D) Positive control tissue exhibited an appropriate IgJ staining pattern (original magnification 200x).</p

Top genes associated with stable sinus rhythm after electrical cardioversion.

<p>Fold Change (FC). Confidence Interval (CI).</p

Participant demographics for biomarker discovery cohort.

<p>Participant demographics for biomarker discovery cohort.</p