“Corpses … coast to coast!” Trauma, gender, and race in 1950s horror comics

During the 1950s, a moral panic around youth culture and delinquency dominated the contemporary imagination. Rock n' roll and the new wave of youth-focused films seemed to critics to posit an alternative culture antagonistic to that of older generations. One cultural form sparked particular censorious intent: the horror comic book. Many critics of the 1940s and 1950s dwelt obsessively on the impact of horror comics on youthful readers. The culmination of this movement was the 1954 Senate Subcommittee Hearings on Juvenile Delinquency, which resulted in the implementation of a harsh new self-regulatory comics code and the end of the horror and crime genres. In this study, we argue that rather than (or perhaps as well as) promoting juvenile delinquency, horror comics served an important social function in that they presented a challenge to the dominant culture in cold war America. They corroborated the veteran experience; questioned faith in science and industry; recognised women as victims of war; and embodied, on occasion, many of the themes of the early Civil Rights movement. It was because of these countercultural impulses that the horror genre in comics was, ultimately, brought to an untimely end

Master race and other stories

In addition to "Master Race," this volume includes "The Flying Machine" (based on a story by Ray Bradbury). Other stories include: "Slave Ship," an unpublished science fiction tale that was only discovered in the decades following EC's demise, "The Monster From The Fourth Dimension," a horror/science fiction shocker that has never been reprinted since its original appearance in 1954, and other Krigstein crime, horror, war, and science fiction stories covering the full gamut of EC titles, including Tales From the Crypt, Crime SuspenStories, Shock SuspenStories, Aces High, and Incredible Science Fictio

Perceived Clinical Significance of Consultant Pharmacist Recommendations in the Skilled Nursing Facility

In an attempt to determine if pharmacists could make significant contributions to SNF patient care in the area of disease management, the drug therapy of the residents of two SNFs was reviewed once monthly for six months by two clinical pharmacist consultants. Pharmacist-identified problems and recommendations were communicated in writing to the medical staff by means of a communication form attached to the patient's chart. Nearly 72 percent of the recommendations made were accepted by the SNF physicians. Descriptions of the cases and corresponding recommendations were distributed to review-panel physicians. These physicians were asked to agree or disagree with the pharmacists' suggestions, and to rate the clinical significance of each recommendation using a modified Likert scale. The clinical pharmacist-consultants were perceived to have had a significant input into disease management in SNF patients. </jats:p

FLT3-TKD Measurable Residual Disease Detection Using Droplet Digital PCR and Clinical Applications in Acute Myeloid Leukemia

The tyrosine kinase domain of the FMS-Like tyrosine kinase 3 (FLT3-TKD) is recurrently mutated in acute myeloid leukemia (AML). Common molecular techniques used in its detection include PCR and capillary electrophoresis, Sanger sequencing and next-generation sequencing with recognized sensitivity limitations. This study aims to validate the use of droplet digital PCR (ddPCR) in the detection of measurable residual disease (MRD) involving the common FLT3-TKD mutations (D835Y, D835H, D835V, D835E). Twenty-two diagnostic samples, six donor controls, and a commercial D835Y positive control were tested using a commercial Bio-rad&reg; ddPCR assay. All known variants were identified, and no false positives were detected in the wild-type control (100% specificity and sensitivity). The assays achieved a limit of detection suitable for MRD testing at 0.01% variant allelic fraction. Serial samples from seven intensively-treated patients with FLT3-TKD variants at diagnosis were tested. Five patients demonstrated clearance of FLT3-TKD clones, but two patients had FLT3-TKD persistence in the context of primary refractory disease. In conclusion, ddPCR is suitable for the detection and quantification of FLT3-TKD mutations in the MRD setting; however, the clinical significance and optimal management of MRD positivity require further exploration