Two high-frequency mutual inductance bridges with high resolution

Two mutual inductance bridges are described for operation up to about 100 kHz. Special attention is paid to the sensitivity and resolution of the bridges. Both bridges can be used to measure variations of about 10 pH in the mutual inductance. The first bridge consists of passive elements only whereas the second bridge is equipped with active circuits

Power distribution in the luminescent waveguide

This paper describes how to calculate the power distribution emitted by luminescent particles which are mixed in the film of the waveguide, i.e., the percentage of the power transported by each guided mode, emitted to the cladding and the substrate. For our sample, they are ~20%, 25%, and 55% separately. Some calculated results have been proved: the powers of the TE and TM modes of the luminescent waveguide in the same order are almost the same; the order of the film mode is lower; its power is larger

The effect of ceria co-doping on chemical stability and fracture toughness of Y-TZP

The fracture toughness and ageing resistance of yttria, ceria-stabilized tetragonal zirconia polycrystals (Y, Ce-TZP) were evaluated as a function of grain size and ceria content. Very fine grained, fully dense materials could be produced by sinter forging at relatively low temperatures (1150–1200 °C). The ageing resistance in hot water (185 °C) of 2 mol% Y2O3-stabilized TZP is strongly enhanced by alloying with ceria. The ceria content necessary to avoid degradation completely, decreases with grain size. The toughness of fully dense Y, Ce-TZP is 7–9 MPa m1/2 for grain sizes down to 0.2 mgrm. No or very little transformation took place during fracturing and no clear variation with grain size was observed for the toughness at grain sizes up to 0.8 mgrm. Reversible transformation and crack deflection may explain the observed toughness values

Glucose sensor based on the LUQUEN-principle

A new type of glucose sensor based on luminescence quenching (LUQUEN) is proposed. In this LUQUEN principle the concentration induced quenching is enlarged by radiationless (excited-state) energy transfer within the luminescent material. We describe the integrated optical detection part and the chemo-optical interface, in which the concentration induced optical changes are based on the binding of glucose. Some experiments on the internal energy transfer are reported, and the results are discussed

Chromoionophores in optical ion sensors

The feasibility of surface plasmon resonance (SPR) for ion sensing has been investigated. Emphasis is laid on a simulation-based optimization of the SP carrying structure, as well as the applicability of a specific chemo—optical interface we have developed. A preliminary result is presented

Surface plasmon dispersion and luminescence quenching applied to planar waveguide sensors for the measurement Of chemical concentrations

Two novel types of planar waveguide sensors for the chemical domain are introduced. Both are realized by thin film technologies. They consist of multilayered structures coated by a very thin organic overlayer that is able to absorb the species to be measured out of the environment. This absorbtion results in a change in its dielectric function. In the first sensor to be demonstrated this change is measured using a surface plasmon mode as a probe. In the second one the radiationless energy transfer from luminescent centres incorporated in one of the layers to the overlayer serves as a probe

Interleukin-21 Is Critically Required in Autoimmune and Allogeneic Responses to Islet Tissue in Murine Models

OBJECTIVE-Type 1 diabetes is an incurable chronic autoimmune disease. Although transplantation of pancreatic islets may serve as a surrogate source of insulin, recipients are subjected to a life of immunosuppression. Interleukin (IL)-21 is necessary for type 1 diabetes in NOD mice. We examined the efficacy of an IL-21-targeted therapy on prevention of diabetes in NOD mice, in combination with syngeneic islet transplantation. In addition, we assessed the role of IL-21 responsiveness in islet allograft rejection in mouse animal models. RESEARCH DESIGN AND METHODS-NOD mice were treated with IL-21R/Fc, an IL-21-neutralizing chimeric protein. This procedure was combined with syngeneic islet transplantation to treat diabetic NOD mice. Survival of allogeneic islet grafts in IL-21R-deficient mice was also assessed. RESULTS-Evidence is provided that IL-21 is continually required by the autoimmune infiltrate, such that insulitis was reduced and reversed and diabetes inhibited by neutralization of IL-21 at a late preclinical stage. Recovery from autoimmune diabetes was achieved by combining neutralization of IL-21 with islet transplantation. Furthermore, IL-21-responsiveness by CD8+ T-cells was sufficient to mediate islet allograft rejection. CONCLUSIONS-Neutralization of IL-21 in NOD mice can inhibit diabetes, and when paired with islet transplantation, this therapeutic approach restored normoglycemia. The influence of IL-21 on a graft-mounted immune response was robust, since the absence of IL-21 signaling prevented islet allograft rejection. These findings suggest that therapeutic manipulation of IL-21 may serve as a suitable treatment for patients with type 1 diabetes. Diabetes 60:867-875, 20111151sciescopu