The effect of protein on the nicotinic acid and tryptophane requirement of the growing rat

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Incoherent Eta Photoproduction from the Deuteron near Threshold

Very recent data for the reaction gamma+d ->eta np, namely total cross sections, angular and momentum spectra, are analyzed within a model that includes contributions from the impulse approximation and next order corrections due to the np and eta-N interactions in the final state. Comparison between the calculations and the new data indicate sizable contributions from the np and eta-N final state interactions. Some systematic discrepancies between the calculations and the data are also found

Thermal Radiation from Nucleons and Mesons

Thermal photon emission rates due to meson-nucleon interactions have been evaluated. An exhaustive set of reactions involving p(\bar p), n(\bar n), rho, omega, a_1, pi and eta is seen to provide a sizeable contribution to the emission rate from hot hadronic matter. Contributions from baryonic resonances are found to be negligibly small

The reaction pi N to pi pi N in a meson-exchange approach

A resonance model for two-pion production in the pion-nucleon reaction is developed that includes information obtained in the analysis of pion-nucleon scattering in a meson-exchange model. The baryonic resonances Delta(1232), N*(1440), N*(1520), N*(1535), and N*(1650) are included. The model reproduces the total cross sections up to kinetic energies of the incident pion of 350 MeV and obtains the shapes of the differential cross sections in reasonable agreement with the data.Comment: 7 pages, 7 figures, 2 table

Polarization phenomena in the reaction NN to NNpi near threshold

First calculations for spin-dependent observables of the reactions $pp \to pp\pi^0$, $pp \to pn\pi^+$ and $pp \to d\pi^+$ near threshold are presented, employing the J\"ulich model for pion production. The influence of resonant (via the excitation of the $\Delta (1232)$) and non-resonant p-wave pion production mechanisms on these observables is examined. For the reactions $pp \to pn\pi^+$ and $pp \to d\pi^+$ nice agreement of our predictions with the presently available data on spin correlation coefficents is observed whereas for $pp \to pp\pi^0$ the description of the data is less satisfying.Comment: 10 pages, 4 figure

A carbon monoxide ‘single breath’ method to measure total haemoglobin mass: a feasibility study

NEW FINDINGS: What is the central question of this study? Is it possible to modify the CO-rebreathing method to acquire reliable measurements of haemoglobin mass in ventilated patients? What is the main finding and its importance? A 'single breath' of carbon monoxide with a subsequent 30 sec breath hold provides almost as exact a measure of haemoglobin mass as the established optimized CO-rebreathing method when applied to healthy subjects. The modified method has now to be checked in ventilated patients before it can be used to quantify the contributions of blood loss and of dilution to the severity of anaemia. ABSTRACT: Anaemia is defined by the concentration of haemoglobin ([Hb]). However, this value is dependent upon both the total circulating haemoglobin mass (tHb-mass) and the plasma volume (PV) - neither of which are routinely measured. Carbon monoxide- (CO) rebreathing methods have been successfully used to determine both PV and tHb-mass in various populations. However, these methods are not yet suitable for ventilated patients. This study aimed to modify the CO-rebreathing procedure such that a single inhalation of a CO bolus would enable its use in ventilated patients. Eleven healthy volunteers performed four CO-rebreathing tests in a randomized order, inhaling an identical CO-volume. In two tests, CO was rebreathed for 2min (oCOR), and in the other two tests, a single inhalation of a CO bolus was conducted with a subsequent breath hold of 15sec (Procnew 15sec) or 30sec (Procnew 30sec). Subsequently, the CO volume in the exhaled air was continuously determined for 20 min. The amount of CO exhaled after 7min (after 20min) for oCOR was 3.1 ±0.3ml (5.9 ±1.1ml); for Procnew 15sec, 8.7 ±3.6ml (12.0 ±4.4ml); and for Procnew 30sec, 5.1 ±2.0ml (8.4 ±2.6ml)). tHb-mass determined by oCOR was 843 ±293g, from Procnew 15sec 821 ±288g (difference: p <0.05), and from Procnew 30sec 849 ±311g. Bland-Altman plots demonstrated slightly lower tHb-mass values for Procnew 15sec compared with oCOR (-21.8 ±15.3g) and similar values for Procnew 30sec. In healthy volunteers, a single inhalation of a CO bolus, preferably followed by a 30 sec breath hold, can be used to determine tHb-mass. These results must now be validated for ventilated patients. This article is protected by copyright. All rights reserved

L-Tryptophan Production by Auxotrophic and Analogue Resistant Mutants of Aureobacterium flavescens

A number of tyrosine plus phenylalanine double auxotrophic mutants were isolated by N-methyl-N-nitro-N-nitrosoguanidine (MNNG) treatment of a locally isolated strain of Aureobacterium flavescens of which 11A39 and 11A17 were selected on the basis of their tryptophan production in a mineral salt medium over other isolated mutant strains. The mutational block in the aromatic amino acid biosynthetic pathway of the selected double auxotrophs were determined. By controlling pH of the production medium to near neutrality, the active growth period could be extended up to 72 h and more tryptophan was accumulated compared to pH unregulated culture where the active growth ceased after 48 h. Further improvement of the tryptophan production has been achieved by stepwise isolation of a mutant strain resistant to the tryptophan analogues p-fluorotryptophan (FT) and 5-methyl tryptophan (MT) from the 11A39. Demand for L-tryptophan as food additive and therapeutic agent is increasing day by day throughout the World, particularly in the underdeveloped and developing countries like India. Still to date India depends on other countries for L-tryptophan. The aim of this work is to develop a potent high yielding, feed back insensitive mutant strain and optimization of its medium pH for maximum production of tryptophan

Aspects of a0-f0 mixing in the reaction pn->da0

Some aspects of a0-f0 mixing effects in the reaction ${\vec p} n\to da^0_0$ with perpendicular polarized proton beam are discussed. An angular--asymmetry parameter $A$ is defined to study those effects. It is shown that, for energies close to the production threshold, the angular--asymmetry parameter $A(\theta, \phi)$ is proportional to the a0-f0 mixing amplitude for arbitrary polar and azimuthal angles $\theta$ and $\phi$ of the outgoing $a_0$ meson. This statement is also valid for arbitrary energies, but then only at polar angles $\theta=0^0$ and $\theta=90^0$. The mass dependence of the differential cross section $d\sigma/dm_{\pi^0\eta}$ in the reaction $pn\to d\pi^0\eta$ in the presence of \mix mixing is also discussed.Comment: 17 pages, 3 Figure

What is the structure of the Roper resonance?

We investigate the structure of the nucleon resonance N^*(1440) (Roper) within a coupled-channel meson exchange model for pion-nucleon scattering. The coupling to pipiN states is realized effectively by the coupling to the sigmaN, piDelta and rhoN channels. The interaction within and between these channels is derived from an effective Lagrangian based on a chirally symmetric Lagrangian, which is supplemented by well known terms for the coupling of the Delta isobar, the omega meson and the 'sigma', which is the name given here to the strong correlation of two pions in the scalar-isoscalar channel. In this model the Roper resonance can be described by meson-baryon dynamics alone; no genuine N^*(1440) (3 quark) resonance is needed in order to fit piN phase shifts and inelasticities.Comment: 55 pages, 14 figure