Effects of Syringe Material and Silicone Oil Lubrication on the Stability of Pharmaceutical Proteins

ABSTRACTCurrently, polymer-based prefillable syringes are being promoted to the pharmaceutical market because they provide an increased break resistance relative to traditionally used glass syringes. Despite this significant advantage, the possibility that barrel material can affect the oligomeric state of the protein drug exists. The present study was designed to compare the effect of different syringe materials and silicone oil lubrication on the protein aggregation. The stability of a recombinant fusion protein, abatacept (Orencia), and a fully human recombinant immunoglobulin G1, adalimumab (Humira), was assessed in silicone oil-free (SOF) and silicone oil-lubricated 1-mL glass syringes and polymer-based syringes in accelerated stress study. Samples were subjected to agitation stress, and soluble aggregate levels were evaluated by size-exclusion chromatography and verified with analytical ultracentrifugation. In accordance with current regulatory expectations, the amounts of subvisible particles resulting from agitation stress were estimated using resonant mass measurement and dynamic flow-imaging analyses. The amount of aggregated protein and particle counts were similar between unlubricated polymer-based and glass syringes. The most significant protein loss was observed for lubricated glass syringes. These results suggest that newly developed SOF polymer-based syringes are capable of providing biopharmaceuticals with enhanced physical stability upon shipping and handling. © 2015 The Authors. Journal of Pharmaceutical Sciences published by Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:527–535, 201

Prospects of development of the specialty «Vocational training (service)»

The article deals with one of the promising areas of development of the training direction "Vocational training" on the example of the profile "Service", which consists in advanced training of teachers of vocational training in the field of image technologies in the fashion and beauty industryВ статье рассматривается одно из перспективных направлений развития направления подготовки «Профессиональное обучение» на примере профиля «Сервис», заключающееся в опережающей подготовке педагогов профессионального обучения в области технологий имиджа в индустрии моды и красот

Worldskills is the purpose of improving the preparation, professional learning pedagogue in design style and image

The article deals with the main directions of improving the training of teachers of vocational training in modern conditions. One of the necessary conditions is to take into account international requirements for training in working professions and specialties of secondary vocational educationВ статье рассматриваются основные направления совершенствования подготовки педагогов профессионального обучения в современных условиях. Одно из необходимых условий – учет международных требований к подготовке по рабочим профессиям и специальностям среднего профессионального образовани

Features of training of design students for professional work-methodological aspect

The article discusses the features of the organization of teaching and creative activity of students through the use of a special method «graphic kaleidoscope», included in the structure of associative synectic technology and aimed at enhancing creative thinking of the future teachers of vocational training in the field of designРассматриваются особенности организации учебно-творческой деятельности студентов на основе применения специального метода «графический калейдоскоп», включенного в структуру ассоциативно-синектической технологии и направленного на активизацию образного мышления будущих педагогов профессионального обучения в области дизайн

Activation of learning and creative activity of the vocational pedagogical university students

The relevance of the problem under study is based on the society’s demand for training students - future professional training teachers ready to solve in a creative manner a wide range of professional and pedagogical tasks, as well as to develop professionally-oriented creative work in the process of training; it is also caused by the insufficient extent of the prior research within the vocational training theory of scientific and methodological mechanisms required for implementing this process. The purpose of the article is to develop a conceptual structural model of professionally-oriented learning and creative activity of the vocational pedagogical university students. Leading method for studying this problem is modelling which allows to consider this problem as the process of goaloriented and deliberate acquiring by future professionals the creative approaches to implementation of professional activity. The article presents a structural model of learning and creative activity of vocational pedagogical university students, justifies the necessity to single out in the structure of the students’ learning and creative activity three interconnected components (creative, professional-pedagogical and personal-acmeological), proves the productivity of activating the learning and creative activity of the vocational pedagogical university students by organizing it as quasi-professional process of searching and solving professional tasks which are subjectively and objectively new, on the basis of using synectics including association methods of activating creative thinking integrated into the its structure. The article can be useful for teachers within the vocational and pedagogical education system, as well as for professionals who develop creative abilities of students based on the heuristic creativity methods. © 2016 Krayukhina et al

The role of ethnocultural heritage in the system of training teachers of vocational training in the field of design

The article discusses the formation of ethno-pedagogical competencies through the inclusion of ethno-cultural approaches in the content of the training of vocational education teachersВ статье рассматриваются вопросы формирования этнопедагогических компетенций посредством включения этнокультурных подходов в содержание подготовки педагогов профессионального обучени

PROFESSIONAL STANDARDS AS TOOLS TO SUPPORT THE DEVELOPMENT OF THE MODEL GRADUATE OF THE BASIC PROFESSIONAL EDUCATIONAL PROGRAMS OF HIGHER EDUCATION «THE TECHNOLOGY OF IMAGE IN THE INDUSTRY OF FASHION AND BEAUTY»

В статье рассматривается основные подходы к разработке модели выпускника основной профессиональной образовательной программы высшего образования «Технологии имиджа в идустрии моды и красоты»The article deals with the main approaches to the development of the model of the graduate of the basic professional educational program of higher education "technologies of image in the fashion and beauty industr

ADVANCED EDUCATION – VECTOR OF DEVELOPMENT OF THE SYSTEM OF CONTINUOUS PROFESSIONAL-PEDAGOGICAL EDUCATION

The article discusses the approaches to reforming the system of vocational education, improving the training of professional and pedagogical personnel through advanced education, presents a model of the system of advanced continuous professional and pedagogical educationВ статье рассматриваются подходы реформирования системы профессионального образования, совершенствования подготовки профессионально-педагогических кадров, через опережающее образование, представлена модель системы опережающего непрерывного профессионально-педагогического образования

The for mation of Ethnic Culture in Future Teachers of Vocational Training Under the Conditions of Network Interaction

The article discusses approaches that contribute to the formation of ethnic culture among future teachers of vocational training in the context of network interaction.В статье рассматриваются подходы способствующие формированию этнической культуры у будущих педагогов профессионального обучения в условиях сетевого взаимодействия