Off-label psychopharmacologic prescribing for children: History supports close clinical monitoring

The review presents pediatric adverse drug events from a historical perspective and focuses on selected safety issues associated with off-label use of medications for the psychiatric treatment of youth. Clinical monitoring procedures for major psychotropic drug classes are reviewed. Prior studies suggest that systematic treatment monitoring is warranted so as to both minimize risk of unexpected adverse events and exposures to ineffective treatments. Clinical trials to establish the efficacy and safety of drugs currently being used off-label in the pediatric population are needed. In the meantime, clinicians should consider the existing evidence-base for these drugs and institute close clinical monitoring

Static recrystallization of cold rolled intermetallic Fe17Al4Cr0.3Zr alloy

The final microstructure of cold rolled intermetallic disordered alloy Fe17Al4Cr0.3Zr was rebuilt during the annealing at moderate temperatures in the range of 800 to 900 °C. The time necessary to obtain recrystallized structure was determined at several annealing temperatures to optimize the processing technology of the plates. The phases present in the material during this process were identified. The grain growth (grain boundary movement) during static recrystallization (SRX) is connected with the interaction with an array of the Laves phase λ1(Fe,Al)2Zr and ZrC particles. The Avrami-based phenomenological model describing kinetics of SRX was developed. The activation energy for recrystallization was estimated.Web of Science2191936193