Organization of students’ independent work in studying physics based on distance learning technology in LMS MOODLE

The aim of the article is to justify and substantiate the importance and usefulness of e-learning courses on the platform LMS MOODLE in the context of improving the quality of independent work of students in the study of high school physics course. Methods. Developed online courses in physics in LMS MOODLE based on the analysis of scientific publications and research, observations, lessons learned and results of educational activities are presented; the peculiarities of their application in terms of improving the effectiveness of different types of independent activity of students of high school are identified. Results. A brief analysis of the main trends of distance learning is given; the experience of the development and application of electronic educational courses on the main sections of the course of physics in the Physics and Mathematics Department at the Institute of Elabuga Kazan (Volga) Federal University is described. It is concluded that the use of e-learning in the educational process enhances the effectiveness of different types of independent activity of students, self-development, and the formation of their professional competence. Scientific novelty. The notion of electronic educational courses and its place in the system of blended learning are clarified. The key features and opportunities for intensification of educational process and enhancing students’ independent work are highlighted. Practical significance. Outlined in the article the possibilities and potential of the spacers on a platform LMS MOODLE, as well as the features of their application can determine ways to optimize and streamline the learning process, improvement of methods and tools for the repose of information, monitoring, diagnosis of different types of self-employment. Presented experience of independent work of students in studying physics course based on e-learning courses can be used in various educational institutions of higher educationЦель статьи – обосновать и аргументировать значимость и целесообразность использования электронных образовательных курсов на платформе LMS MOODLE в контексте повышения качества самостоятельной работы студентов при изучении вузовского курса физики. Методы и методики. На основе анализа научных публикаций и исследований, наблюдения, обобщения опыта и результатов педагогической деятельности представлены разработанные электронные курсы по физике в LMS MOODLE и выявлены особенности их применения в плане повышения эффективности различных видов самостоятельной деятельности студентов вуза. Результаты. Дан краткий анализ основных направлений дистанционного обучения, представлен опыт разработки и применения электронных образовательных курсов по основным разделам курса физики на физико-математическом факультете Елабужского института Казанского (Приволжского) Федерального университета. Сделан вывод о том, что использование электронных курсов в учебном процессе способствует повышению эффективности различных видов самостоятельной деятельности студентов, саморазвитию, формированию их профессиональных компетенций. Научная новизна. Уточнено понятие электронных образовательных курсов и их место в системе смешанного обучения. Выделены их основные отличительные признаки и возможности для интенсификации учебного процесса и активизации самостоятельной работы студентов. Практическая значимость. Изложенные в статье возможности дистанционных элементов на платформе LMS MOODLE, а также особенности их применения позволяют определить пути оптимизации и рационализации учебного процесса, усовершенствования методов и средств представления информации, мониторинга, диагностики различных видов самостоятельной деятельности. Описанный опыт организации самостоятельной работы студентов при изучении курса физики на основе электронных курсов может быть использован в различных образовательных учреждениях высшего профессионального образованиягосударственная поддержка Казанского (Приволжского) федерального университет

Occlusion abnormality and flat foot deformity: synergy in orthodontics and orthopaedics

The article examines the interrelation between malocclusion and foot deformities in adult patients. Revealing of this interrelation is necessary as it is not sufficiently reviewed in the available sources. However it is essential in prophylaxis, treatment and effective rehabilitation of orthodontic diseases. The group of grown up patient was researched: foot deformities were diagnosed via computer scanning, malocclusions were determined while clinical examination. During the study we came to a conclusion that there is an interconnection of distal occlusion and transverse flat foot, of mesial occlusion and longitudinal flat foot. We consider that comprehending of this interrelation is important in complex rehabilitation of patients with musculoskeletal disorders.в статье рассмотрена взаимосвязь патологий прикуса и деформаций стопы у взрослых пациентов. Необходимость выявления данной связи в том, что она недостаточно освещена в доступной литературе, однако необходима для профилактики, лечения и эффективной реабилитации пациентов с ортодонтической патологией. Проведено исследование группы взрослых людей: деформации стоп диагностировали при помощи компьютерного сканирования, патология прикуса определялась при клиническом осмотре. В ходе исследования сделан вывод о наличии взаимосвязи дистального прикуса с поперечным плоскостопием, а мезиального – с продольным. Понимание данной связи считаем важным для комплексной реабилитации людей с нарушениями опорно-двигательного аппарата

Characterization of the complete genome sequence of the recombinant norovirus GII.P16/GII.4_Sydney_2012 revealed in Russia

Noroviruses (the Caliciviridae family) are a common cause of acute gastroenteritis in all age groups. These small non-envelope viruses with a single-stranded (+)RNA genome are characterized by high genetic variability. Continuous changes in the genetic diversity of co-circulating noroviruses and the emergence of new recombinant variants are observed worldwide. Recently, new recombinant noroviruses with a novel GII.P16 polymerase associated with different capsid proteins VP1 were reported. As a part of the surveillance study of sporadic cases of acute gastroenteritis in Novosibirsk, a total of 46 clinical samples from children with diarrhea were screened in 2016. Norovirus was detected in six samples from hospitalized children by RT-PCR. The identified noroviruses were classified as recombinant variants GII.P21/GII.3, GII.Pe/GII.4_Sydney_2012, and GII.P16/GII.4_Sydney_2012 by sequencing of the ORF1/ORF2 junction. In Novosibirsk, the first appearance of the new recombinant genotype GII.P16/GII.4_Sydney_2012 was recorded in spring 2016. Before this study, only four complete genome sequences of the Russian GII.P16/GII.3 norovirus strains were available in the GenBank database. In this work, the complete genome sequence of the Russian strain Hu/GII.P16-GII.4/RUS/Novosibirsk/NS16-C38/2016 (GenBank KY210980) was determined. A comparison of the nucleotide and the deduced amino acid sequences showed a high homology of the Russian strain with GII.P16/GII.4_Sydney_2012 strains from other parts of the world. A comparative analysis showed that several unique substitutions occurred in the GII.P16 polymerase, N-terminal p48 protein, and minor capsid protein VP2 genes, while no unique changes in the capsid VP1 gene were observed. A functional significance of these changes suggests that a wide distribution of the strains with the novel GII.P16 polymerase may be associated both with several amino acid substitutions in the polymerase active center and with the insertion of glutamic acid or glycine in an N-terminal p48 protein that blocks the secretory immunity of intestinal epithelial cells. Further monitoring of genotypes will allow determining the distribution of norovirus recombinants with the polymerase GII.P16 in Russia

Is Privacy Controllable?

One of the major views of privacy associates privacy with the control over information. This gives rise to the question how controllable privacy actually is. In this paper, we adapt certain formal methods of control theory and investigate the implications of a control theoretic analysis of privacy. We look at how control and feedback mechanisms have been studied in the privacy literature. Relying on the control theoretic framework, we develop a simplistic conceptual control model of privacy, formulate privacy controllability issues and suggest directions for possible research.Comment: The final publication will be available at Springer via http://dx.doi.org/ [in press

Influence of the type of feeding on the health status, physical development of children under 1 year of age

The purpose of the study – to assess the impact of natural and artificial feeding on the health status of children in the first year of life.Цель исследования – оценить влияние естественного и искусственного видов вскармливания на состояние здоровья детей первого года жизни

Vaccination against children's influenza who become ill with influenza and non-influenza respiratory infections in the 2018 season.

The article reviewed vaccination against children's influenza who become ill with influenza and non-influenza respiratory infections hospitalized in inpatient. The incidence rate was assessed depending on the organization and age of children.В статье проанализирована привитость против гриппа детей, заболевших гриппом и негриппозными респираторными инфекциями, госпитализированных в стационар. Проведена оценка заболеваемости в зависимости от организованности и возраста детей

Analysis of Lyme-borreliosis disease for 2020-2021 in Yekaterinburg

The aim of the study - to identify clinical and laboratory features in children with Lyme borreliosis in the Sverdlovsk region for 2020-2021Цель исследования - выявить клинические и лабораторные особенности у детей с Лайм-боррелиозом в Свердловской области за 2020-2021 г

Methamphetamine-Induced Dopamine-Independent Alterations in Striatal Gene Expression in the 6-Hydroxydopamine Hemiparkinsonian Rats

Unilateral injections of 6-hydroxydopamine into the medial forebrain bundle are used extensively as a model of Parkinson's disease. The present experiments sought to identify genes that were affected in the dopamine (DA)–denervated striatum after 6-hydroxydopamine-induced destruction of the nigrostriatal dopaminergic pathway in the rat. We also examined whether a single injection of methamphetamine (METH) (2.5 mg/kg) known to cause changes in gene expression in the normally DA-innervated striatum could still influence striatal gene expression in the absence of DA. Unilateral injections of 6-hydroxydopamine into the medial forebrain bundle resulted in METH-induced rotational behaviors ipsilateral to the lesioned side and total striatal DA depletion on the lesioned side. This injection also caused decrease in striatal serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels. DA depletion was associated with increases in 5-HIAA/5-HT ratios that were potentiated by the METH injection. Microarray analyses revealed changes (± 1.7-fold, p<0.025) in the expression of 67 genes on the lesioned side in comparison to the intact side of the saline-treated hemiparkinsonian animals. These include follistatin, neuromedin U, and tachykinin 2 which were up-regulated. METH administration caused increases in the expression of c-fos, Egr1, and Nor-1 on the intact side. On the DA-depleted side, METH administration also increased the expression of 61 genes including Pdgf-d and Cox-2. There were METH-induced changes in 16 genes that were common in the DA-innervated and DA-depleted sides. These include c-fos and Nor-1 which show greater changes on the normal DA side. Thus, the present study documents, for the first time, that METH mediated DA-independent changes in the levels of transcripts of several genes in the DA-denervated striatum. Our results also implicate 5-HT as a potential player in these METH-induced alterations in gene expression because the METH injection also caused significant increases in 5-HIAA/5-HT ratios on the DA-depleted side

Methamphetamine Inhibits the Glucose Uptake by Human Neurons and Astrocytes: Stabilization by Acetyl-L-Carnitine

Methamphetamine (METH), an addictive psycho-stimulant drug exerts euphoric effects on users and abusers. It is also known to cause cognitive impairment and neurotoxicity. Here, we hypothesized that METH exposure impairs the glucose uptake and metabolism in human neurons and astrocytes. Deprivation of glucose is expected to cause neurotoxicity and neuronal degeneration due to depletion of energy. We found that METH exposure inhibited the glucose uptake by neurons and astrocytes, in which neurons were more sensitive to METH than astrocytes in primary culture. Adaptability of these cells to fatty acid oxidation as an alternative source of energy during glucose limitation appeared to regulate this differential sensitivity. Decrease in neuronal glucose uptake by METH was associated with reduction of glucose transporter protein-3 (GLUT3). Surprisingly, METH exposure showed biphasic effects on astrocytic glucose uptake, in which 20 µM increased the uptake while 200 µM inhibited glucose uptake. Dual effects of METH on glucose uptake were paralleled to changes in the expression of astrocytic glucose transporter protein-1 (GLUT1). The adaptive nature of astrocyte to mitochondrial β-oxidation of fatty acid appeared to contribute the survival of astrocytes during METH-induced glucose deprivation. This differential adaptive nature of neurons and astrocytes also governed the differential sensitivity to the toxicity of METH in these brain cells. The effect of acetyl-L-carnitine for enhanced production of ATP from fatty oxidation in glucose-free culture condition validated the adaptive nature of neurons and astrocytes. These findings suggest that deprivation of glucose-derived energy may contribute to neurotoxicity of METH abusers