Operations Management: Processes and Supply Chains -9/E.

OPERATIONS MANAGEMENT PROCESSES AND SUPPLY CHAINS This Global Edition has been edited to include enhancements making it more relevant to studens outside the United States. The editorial taem at Pearson has worked closely with educators around the globe to include: • NEW! Supply Chain Orientation: This text uniquely builds the concept of a supply chain from the ground up allowing students to see how effective internal processes lead the best supply chairs. • NEW! Streamlined Design: Fewer chapters, less pages, and enhanced clarity allows students to engage each topic efficiently and effectively. Figures and photos have been added to improve the presentation of key concepts and techniques. • NEW! Global Examples and Cases: Examples from Europe, Asia, Middle East and Australia are presented throughout the text for students in these regions to better appreciate the concepts presented

Modelling of the crystallization front – particles interactions in ZnAl/(SiC)p composites

The presented work focuses on solid particle interactions with the moving crystallization front during a solidification of the metal matrix composite. The current analyses were made for silicon carbide particles and ZnAl alloy with different additions of aluminium. It was found, that the chemical composition of the metal matrix influences the behaviour of SiC particles. At the same time calculations of the forces acting on a single particle near the crystallization front were performed. For each alloy type the critical conditions that determine whether particle will be absorbed or pushed, were specified

EPRL/FK Group Field Theory

The purpose of this short note is to clarify the Group Field Theory vertex and propagators corresponding to the EPRL/FK spin foam models and to detail the subtraction of leading divergences of the model.Comment: 20 pages, 2 figure

Quantum creep and quantum creep transitions in 1D sine-Gordan chains

Discrete sine-Gordon (SG) chains are studied with path-integral molecular dynamics. Chains commensurate with the substrate show the transition from collective quantum creep to pinning at bead masses slightly larger than those predicted from the continuous SG model. Within the creep regime, a field-driven transition from creep to complete depinning is identified. The effects of disorder in the external potential on the chain's dynamics depend on the potential's roughness exponent $H$, i.e., quantum and classical fluctuations affect the current self-correlation functions differently for $H = 1/2$.Comment: 4 pages, 3 figure

Why Matrix theory works for oddly shaped membranes

We give a simple proof of why there is a Matrix theory approximation for a membrane shaped like an arbitrary Riemann surface. As corollaries, we show that noncompact membranes cannot be approximated by matrices and that the Poisson algebra on any compact phase space is U(infinity). The matrix approximation does not appear to work properly in theories such as IIB string theory or bosonic membrane theory where there is no conserved 3-form charge to which the membranes couple.Comment: 8 pages, 4 figures, revtex; references adde

Experiments and 3D simulations of flow structures in junctions and their influence on location of flowmeters

International audienceOpen-channel junctions are common occurrences in sewer networks and flow rate measurement often occurs near these singularities. Local flow structures are 3-dimensional, impact on the representativeness of the local flow measurements and thus lead to deviations in the flow rate estimation. The present study aims i) to measure and simulate the flow pattern in a junction flow, ii) to analyze the impact of the junction on the velocity distribution according to the distance from the junction and thus iii) to evaluate the typical error derived from the computation of the flow rate close to the junction

Number of apoptotic cells as a prognostic marker in invasive breast cancer

Apoptosis plays an important role in tumorigenesis. Tumour growth is determined by the rate of cell proliferation and cell death. We counted the number of apoptotic cells in haematoxylin and eosin (H&E)-stained tumour sections in series of 172 grade I and II invasive breast cancers with long-term follow-up. The number of apoptotic cells in ten high-power fields were converted to the number of apoptotic cells per mm2to obtain the apoptotic index (AI). The AI showed a positive correlation to the mitotic activity index (MAI) (P = 0.0001), histological grade (P< 0.0001) and worse tumour differentiation. Patients with high AI showed shorter overall survival than patients with low AI in the total group as well as in the lymph node-positive group. Tumour size, MAI, lymph node status and AI were independent prognostic indicators in multivariate analysis. The AI was shown to be of additional prognostic value to the MAI in the total patients group as well as in the lymph node-positive group. The correlation between the AI and the MAI points to linked mechanisms of apoptosis and proliferation. Since apoptotic cells can be counted with good reproducibility in H&E-stained tumour sections, the AI may be used as an additional prognostic indicator in invasive breast cancer. © 2000 Cancer Research Campaig

Stochastic Interpolation of Precipitation Data From Multiple Sensors

Introduction: This report summarizes the work conducted under Grant No. ECE-8419189, Stochastic Interpolation of Precipitation Data from Multiple Sensors, which was awarded to Utah State University in September, 1985, and completed February 29, 1988. it also covers work under a supplemental award made in February, 1986. The final report is organized into four sections. The following section presents the objective of the research and a brief problem statment. Section 3 contains a summary of second-year work including the project team, work plan, work completed, and publications. In Section4, project conclusions are summarized. A summary of on-going future work is given in Section 5, together with our plans for publication of research results from this project. Copies of preliminary draft manuscripts and completed technical reports which have been prepared as a result of second-year activities are contained in the Appendices. A cummulative summary of project publications is presented in Appendix A

Determination of an optimal response cut-off able to predict progression-free survival in patients with well-differentiated advanced pancreatic neuroendocrine tumours treated with sunitinib: an alternative to the current RECIST-defined response.

BACKGROUND: Sunitinib prolongs progression-free survival (PFS) in patients with advanced pancreatic neuroendocrine tumours (pNET). Response Evaluation Criteria in Solid Tumors (RECIST)-defined partial responses (PR; classically defined as ⩾30% size decrease from baseline) are infrequent. METHODS: Individual data of pNET patients from the phase II [NCT00056693] and pivotal phase III [NCT00428597] trials of sunitinib were analysed in this investigator-initiated, post hoc study. The primary objective was to determine the optimal RECIST (v.1.0) response cut-off value to identify patients who were progression-free at 11 months (median PFS in phase III trial); and the most informative time-point (highest area under the curve (AUC) by receiver operating characteristic (ROC) analysis and logistic regression) for prediction of benefit (PFS) from sunitinib. RESULTS: Data for 237 patients (85 placebo; 152 sunitinib (n=66.50 mg \u274-weeks on/2-weeks off\u27 schedule; n=86 \u2737.5 mg continuous daily dosing (CDD)\u27)) and 788 scans were analysed. The median PFS for sunitinib and placebo were 9.3 months (95% CI 7.6-12.2) and 5.4 months (95% CI 3.5-6.01), respectively (hazard ratio (HR) 0.43 (95% CI 0.29-0.62); P CONCLUSIONS: A 10% reduction within marker lesions identifies pNET patients benefiting from sunitinib treatment with implications for maintenance of dose intensity and future trial design