4,125 research outputs found
Large-scale disasters and the insurance industry
We investigate the effect of the 20 largest â in terms of insured losses â man-made or natural disasters on the insurance industry. We show via an event study that insurance markets worldwide are quite resilient to unexpected losses to capital and are even outperforming the general market subsequent to great disasters. --disaster,insurance industry,event-study
Pharmakogenetik in der Rechtsmedizin
Zusammenfassung: Die Pharmakogenetik beschĂ€ftigt sich mit den genetisch bedingten Unterschieden bei der Arzneimittel-, Drogen oder Giftwirkung und ist somit auch fĂŒr die rechtsmedizinische Begutachtung von Bedeutung. Die hĂ€ufigsten Sequenzvariationen in der DesoxyribonukleinsĂ€ure ("deoxyribonucleic acid", DNA) sind die "single nucleotide polymorphisms" (SNP). Neben den metabolisierenden Enzymen, z.B. Zytochrom-P450- (CYP-)Isoenzyme, können Transportproteine oder auch Rezeptorproteine betroffen sein. FĂŒhren sie tatsĂ€chlich zu Ănderungen in der FunktionalitĂ€t der Proteine, kann es zu deutlichen interindividuellen Unterschieden in der Pharmakokinetik und Pharmakodynamik kommen. Aber auch Faktoren wie Komedikation, Alter, Geschlecht, Hormon- und ErnĂ€hrungsstatus sowie Umweltfaktoren und KomorbiditĂ€t sind von groĂer Bedeutung. Dies wird hauptsĂ€chlich durch Induktion oder Inhibition der AktivitĂ€t der Funktionsproteine bewirkt. Diese Interaktionen sind bei der Begutachtung ebenfalls zu berĂŒcksichtige
Event Reconstruction with MarlinReco at the ILC
After an overview of the modular analysis and reconstruction framework Marlin
an introduction on the functionality of the Marlin-based reconstruction package
MarlinReco is given. This package includes a full set of modules for event
reconstruction based on the Particle Flow approach. The status of the software
is reviewed and recent results using this software package for event
reconstruction are presented.Comment: 6 pages, 2 .eps figures, to appear in Proc. LCWS06, Bangalore, March
200
Enzyme-linked immunosorbent assay for urinary albumin at low concentrations
We describe an enzyme-linked immunosorbent assay (ELISA) for urinary albumin. It requires only commercially available reagents, can detect as little as 16 micrograms of albumin per liter, and analytical recovery ranges from 92 to 116%. The assay is simple, rapid, and inexpensive. Albumin excretion was 6.2 (SD 4.1) mg/24 h in healthy subjects (n = 40), 14.7 (SD 7.2) mg/24 h in albumin-test-strip-negative Type I diabetics (n = 11), and 19.7 (SD 16.2) mg/24 h in patients with essential hypertension (n = 12)
Quantum Gravitational Contributions to the CMB Anisotropy Spectrum
We derive the primordial power spectrum of density fluctuations in the
framework of quantum cosmology. For this purpose we perform a Born-Oppenheimer
approximation to the Wheeler-DeWitt equation for an inflationary universe with
a scalar field. In this way we first recover the scale-invariant power spectrum
that is found as an approximation in the simplest inflationary models. We then
obtain quantum gravitational corrections to this spectrum and discuss whether
they lead to measurable signatures in the CMB anisotropy spectrum. The
non-observation so far of such corrections translates into an upper bound on
the energy scale of inflation.Comment: 4 pages, v3: sign error in Eq. (5) and its consequences correcte
Large-scale disasters and the insurance industry
We investigate the impact of the 20 largest - in terms of insured losses - man-made or natural disasters on various insurance industry stock indices. We show via an event study that insurance sectors worldwide are quite resilient, in a market value sense, to unexpected losses to capital: our data provide evidence that equity market investors believe that insurance companies will on average be able to make losses back over the foreseeable future, i.e. that the adverse shocks to equity which have resulted from these catastrophes will be compensated by either an outward shift of the demand curve or an ability to raise premiums, or both
Solid-state synthesis and characterization of Ï-Alkane complexes, [Rh(L2)(η2,η2-C7H12)][BArF4] (L2 = bidentate chelating phosphine)
The use of solid/gas and single-crystal to single-crystal synthetic routes is reported for the synthesis and characterization of a number of Ï-alkane complexes: [Rh(R2P(CH2)nPR2)(η2,η2-C7H12)][BArF4]; R = Cy, n = 2; R = iPr, n = 2,3; Ar = 3,5-C6H3(CF3)2. These norbornane adducts are formed by simple hydrogenation of the corresponding norbornadiene precursor in the solid state. For R = Cy (n = 2), the resulting complex is remarkably stable (months at 298 K), allowing for full characterization using single-crystal X-ray diffraction. The solid-state structure shows no disorder, and the structural metrics can be accurately determined, while the 1H chemical shifts of the Rh···HâC motif can be determined using solid-state NMR spectroscopy. DFT calculations show that the bonding between the metal fragment and the alkane can be best characterized as a three-center, two-electron interaction, of which ÏCH â Rh donation is the major component. The other alkane complexes exhibit solid-state 31P NMR data consistent with their formation, but they are now much less persistent at 298 K and ultimately give the corresponding zwitterions in which [BArF4]â coordinates and NBA is lost. The solid-state structures, as determined by X-ray crystallography, for all these [BArF4]â adducts are reported. DFT calculations suggest that the molecular zwitterions within these structures are all significantly more stable than their corresponding Ï-alkane cations, suggesting that the solid-state motif has a strong influence on their observed relative stabilities
Bounds on R-parity violating supersymmetric couplings from leptonic and semi-leptonic meson decays
We present a comprehensive update of the bounds on R-Parity violating
supersymmetric couplings from lepton-flavour- and lepton-number-violating decay
processes. We consider tau and mu decays as well as leptonic and semi-leptonic
decays of mesons. We present several new bounds resulting from tau, eta and
Kaon decays and correct some results in the literature concerning B-meson
decays.Comment: 30 pages; changed title, updated some bounds from the literature from
different references, added reference
- âŠ