Mobilization of human hematopoietic stem/progenitor-enriched CD34+ cells into peripheral blood during stress related to ischemic stroke.

The bone marrow-derived stem/progenitor cells were demonstrated to play an important role in a regeneration of damaged tissue. Based on these observations we asked whether the stroke-related stress triggers mobilization of stem/progenitor cells from the bone marrow into the peripheral blood, which subsequently could contribute to regeneration of damaged organs. To address this issue, the peripheral blood samples were harvested from patients with ischemic stroke during the first 24 hrs as well as after the 48 (2nd day) and 144 hrs (6th day) since the manifestation of symptoms. In these patients we evaluated the percentage of hematopoietic stem/progenitor-enriched CD34+ cells by employing flow cytometry and the number of hematopoietic progenitor cells for the granulocyto-monocytic (CFU-GM) and erythroid (BFU-E)-lineages circulating in peripheral blood. We concluded that stress related to ischemic stroke triggers the mobilization of hematopoietic stem/progenitor cells from the bone marrow into peripheral blood. These circulating stem/progenitor cells may play an important role in the process of regeneration of the ischemic tissue

Preservation of the culture and language of the Lusatian Sorbs in Brandenburg

Lusatian Serbs, also called Sorbs, are people living in Upper, Middle and Lower Lusatia. This small nation is a remnant of the Slavic settlement in East Germany (Brandenburg and Saxony). Lower Lusatia now lies in the state of Brandenburg, and Upper and Middle Lusatia in the Free State of Saxony. According to official data, in these areas there are approximately 50,000 – 60,000 Lusatian Serbs, of which it is assumed that two-thirds reside in Saxony and one-third in Brandenburg. The article draws attention to formal and legal issues aimed at protecting the culture and the Lower Sorbian language. The analyses carried out concern the general provisions of the European Union, Germany and more detailed guidelines adopted in Brandenburg. Legal acts are important formal means of protection, the effectiveness of which is expressed by the way of practice. Unfortunately, in Brandenburg, many of the existing regulations have no proper effect on everyday life or are distorted. The article is an attempt to identify the assumptions with the implementation, to recognize the limitations, but also to discuss the directions of improving the existing state.Serbowie łużyccy, nazywani w języku polskim również Serbołużyczanami, to ludność zamieszkująca Górne, Środkowe i Dolne Łużyce. Ten mały naród to pozostałość osadnictwa słowiańskiego na terenie Niemiec Wschodnich (Brandenburgia i Saksonia). Dolne Łużyce leżą obecnie w kraju związkowym Brandenburgia, zaś Górne i Środkowe w Wolnym Kraju Saksonia. Według oficjalnych danych na tych terenach zamieszkuje obecnie około 50 000–60 000 Serbów łużyckich, z tego przyjmuje się, że dwie trzecie rezyduje w Saksonii, zaś jedna trzecia w Brandenburgii. W artykule zwrócono uwagę na kwestie formalnoprawne skierowane na ochronę kultury i języka dolnołużyckiego. Wyprowadzone analizy dotyczą postanowień ogólnych Unii Europejskiej, Niemiec oraz szczegółowych wytycznych przyjętych w Brandenburgii. Akty prawne są ważnym, formalnym sposobem ochrony, którego skuteczność wyraża sposób praktykowania. Niestety w Brandenburgii wiele z istniejących zapisów nie przekłada się na codzienność lub jest wypaczana. Celem artykułu jest podjęcie próby identyfikacji założeń formalnoprawnych z ich realizacją, rozpoznania ograniczeń, ale też dyskusji nad kierunkami poprawy istniejącego stanu. Zastosowano metodę analizy dokumentów

Mobilization of human hematopoietic stem/progenitor-enriched CD34+ cells into peripheral blood during stress related to ischemic stroke.

The bone marrow-derived stem/progenitor cells were demonstrated to play an important role in a regeneration of damaged tissue. Based on these observations we asked whether the stroke-related stress triggers mobilization of stem/progenitor cells from the bone marrow into the peripheral blood, which subsequently could contribute to regeneration of damaged organs. To address this issue, the peripheral blood samples were harvested from patients with ischemic stroke during the first 24 hrs as well as after the 48 (2nd day) and 144 hrs (6th day) since the manifestation of symptoms. In these patients we evaluated the percentage of hematopoietic stem/progenitor-enriched CD34+ cells by employing flow cytometry and the number of hematopoietic progenitor cells for the granulocyto-monocytic (CFU-GM) and erythroid (BFU-E)-lineages circulating in peripheral blood. We concluded that stress related to ischemic stroke triggers the mobilization of hematopoietic stem/progenitor cells from the bone marrow into peripheral blood. These circulating stem/progenitor cells may play an important role in the process of regeneration of the ischemic tissue