Resonance structure in the {\gamma}{\gamma} and π0π0\pi^0\pi^0 systems in dC interactions

Along with $\pi^0$ and {\eta} mesons, a resonance structure in the invariant mass spectrum of two photons at M{\gamma}{\gamma} = 360 \pm 7 \pm 9 MeV is observed in the reaction d + C \rightarrow {\gamma} + {\gamma} + X at momentum 2.75 GeV/c per nucleon. Estimates of its width and production cross section are {\Gamma} = 64 \pm 18 MeV and $\sigma_{\gamma\gamma}$ = 98 \pm 24 {\mu}b, respectively. The collected statistics amount to 2339 \pm 340 events of 1.5 \cdot 10^6 triggered interactions of a total number ~ 10^12 of dC-interactions. The results on observation of the resonance in the invariant mass spectra of two $\pi^0$ mesons are presented: the data obtained in the d + C \rightarrow {\gamma} + {\gamma} reaction is confirmed by the d + C \rightarrow $\pi^0$ + $\pi^0$ reaction: $M_{\pi^0\pi^0}$ = 359.2 \pm 1.9 MeV, {\Gamma} = 48.9 \pm 4.9 MeV; the ratio of Br(R\rightarrow{\gamma}{\gamma}) / Br(R\rightarrow$\pi^0\pi^0$) = (1.8 {\div} 3.7)\cdot10^-3.Comment: 10 pages, 11 figure

Redox-sensitive system of the antioxidant-responsive element as a new target for tuberculosis treatment

The emergence of drug-resistant TB caused by resistance to antibiotic strains of bacteria, prompted to search for new "organism-oriented" ("host-targeted") adjuvant treatment strategies. Free radical oxidation plays an important role in the development and exacerbation of the pathological process. The main system of cell protection from oxidative stress is the redox-sensitive signaling system of the antioxidant-responsive element of the Keap1/Nrf2/ARE, which includes the transcription factor Nrf2, which is under constant control of a repressor protein Keapl. Nrf2 regulates the expression of genes containing the antioxidant-responsive element ARE in their promoters, Keapl is a kind of molecular "sensor" of modifications in the intracellular homeostasis. The inextricable link between these molecular structures allows combining them into a single redox-sensitive signaling system Keap1/Nrf2/ARE. Nrf2 modulates resistance of the organism to various infections: activation of Nrf2 prevents the penetration and replication of influenza A virus, contributes to resistance to various bacterial agents (Salmonella typhimurium, Pseudomonas aeruginosa). The aim of this work was to study the influence of induction system Keap1/Nrf2/ARE on the formation of mycobacterial granulomas in vitro. In vitro model was used to study effect of induction of the redox-sensitive signaling system Keap1/Nrf2/ARE in time course of granuloma formation. It was found that the activation of Keap1/Nrf2/ARE system led to acceleration of granuloma formation, which was then replaced by the dissociation process. These data allowed us to consider Keapl/Nrß/ARE system as a new therapeutic target in the tuberculosis treatment

Digital receivers for low-frequency radio telescopes UTR-2, URAN, GURT

This paper describes digital radio astronomical receivers used for decameter and meter wavelength observations. This paper describes digital radio astronomical receivers used for decameter and meter wavelength observations. Since 1998, digital receivers performing on-the-fly dynamic spectrum calculations or waveform data recording without data loss have been used at the UTR-2 radio telescope, the URAN VLBI system, and the GURT new generation radio telescope. Here we detail these receivers developed for operation in the strong interference environment that prevails in the decameter wavelength range. Data collected with these receivers allowed us to discover numerous radio astronomical objects and phenomena at low frequencies, a summary of which is also presented.Comment: 24 pages, 15 figure

Baikal-GVD: status and prospects

Baikal-GVD is a next generation, kilometer-scale neutrino telescope under construction in Lake Baikal. It is designed to detect astrophysical neutrino fluxes at energies from a few TeV up to 100 PeV. GVD is formed by multi-megaton subarrays (clusters). The array construction started in 2015 by deployment of a reduced-size demonstration cluster named "Dubna". The first cluster in its baseline configuration was deployed in 2016, the second in 2017 and the third in 2018. The full scale GVD will be an array of ~10000 light sensors with an instrumented volume of about 2 cubic km. The first phase (GVD-1) is planned to be completed by 2020-2021. It will comprise 8 clusters with 2304 light sensors in total. We describe the design of Baikal-GVD and present selected results obtained in 2015-2017.Comment: 9 pages, 8 figures. Conference proceedings for QUARKS201