Classification of Cohomogeneity One Strings

We define the cohomogeneity one string, string with continuous symmetries, as its world surface is tangent to a Killing vector field of a target space. We classify the Killing vector fields by an equivalence relation using isometries of the target space. We find that the equivalence classes of Killing vectors in Minkowski spacetime are partitioned into seven families. It is clarified that there exist seven types of strings with spacelike symmetries and four types of strings with timelike symmetries, stationary strings.Comment: 8 page

Ontology Mapping of PATO to YATO for the improvement of interoperability of quality description

To facilitate broad interoperability for phenotype information between different ontological frameworks, we developed a reference ontology, PATO2YATO_Quality, with the careful mapping of terms of PATO which is a quality ontology commonly used for biological phenotype annotation to the latest top-level ontology, YATO, which represents advanced modeling of quality-related concepts. As a result, YATO framework enabled to describe changes of phenotypic qualities along the courses of time in ontologically correct way and sophisticated classification and representation of interrelationships among quality-related concepts to provide fully integration of qualitative values and quantitative values obtained from phenotyping experiments and advanced representation of more detailed quality description. Thus, PATO2YATO_Quality will contribute to advanced integration of phenotypic qualities

Can inhomogeneties accelerate the cosmic volume expansion?

If expanding and contracting regions coexist in the universe, the speed of the cosmic volume expansion can be accelerated. We construct simple inhomogeneous dust-filled universe models in which the speed of the cosmic volume expansion is accelerated for finite periods. These models are constructed by removing spherical domains from the Einstein-de Sitter universe and filling each domain with a Lemaitre-Tolman-Bondi dust sphere possessing the same gravitational mass as the removed region. This represents an exact solution of the Einstein equations. We find that acceleration of the cosmic volume expansion is realized in some cases when the size of the contracting region is comparable to the horizon radius of the Einstein-de Sitter universe though this model is very different from the universe observed today. This result implies that non-linear general relativistic effects of inhomogeneities are very important to realize the acceleration of the cosmic volume expansion.Comment: 12 pages,5 figures. version published in Progress of Theoretical Physic

Stationary Rotating Strings as Relativistic Particle Mechanics

Stationary rotating strings can be viewed as geodesic motions in appropriate metrics on a two-dimensional space. We obtain all solutions describing stationary rotating strings in flat spacetime as an application. These rotating strings have infinite length with various wiggly shapes. Averaged value of the string energy, the angular momentum and the linear momentum along the string are discussed.Comment: 20pages, 7 figure

A novel M cell–specific carbohydrate-targeted mucosal vaccine effectively induces antigen-specific immune responses

Mucosally ingested and inhaled antigens are taken up by membranous or microfold cells (M cells) in the follicle-associated epithelium of Peyer's patches or nasopharynx-associated lymphoid tissue. We established a novel M cell–specific monoclonal antibody (mAb NKM 16–2-4) as a carrier for M cell–targeted mucosal vaccine. mAb NKM 16–2-4 also reacted with the recently discovered villous M cells, but not with epithelial cells or goblet cells. Oral administration of tetanus toxoid (TT)– or botulinum toxoid (BT)–conjugated NKM 16–2-4, together with the mucosal adjuvant cholera toxin, induced high-level, antigen-specific serum immunoglobulin (Ig) G and mucosal IgA responses. In addition, an oral vaccine formulation of BT-conjugated NKM 16–2-4 induced protective immunity against lethal challenge with botulinum toxin. An epitope analysis of NKM 16–2-4 revealed specificity to an α(1,2)-fucose–containing carbohydrate moiety, and reactivity was enhanced under sialic acid–lacking conditions. This suggests that NKM 16–2-4 distinguishes α(1,2)-fucosylated M cells from goblet cells containing abundant sialic acids neighboring the α(1,2) fucose moiety and from non-α(1,2)-fucosylated epithelial cells. The use of NKM 16–2-4 to target vaccine antigens to the M cell–specific carbohydrate moiety is a new strategy for developing highly effective mucosal vaccines