9 research outputs found
How Effective are Policies to Reduce Gasoline Consumption? Evaluating a Quasi-Natural Experiment in Spain
Full text linkLanguage Development in Children With Cleft Palate With or Without Cleft Lip Adopted From Non–English-Speaking Countries
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Research on the reaction progress of thermodynamic combustion based on arc and jet plasma energies using experimental and analytical methods
No full textEvaluation of the Influence of Diethyl Ether (DEE) Addition on Selected Physicochemical Properties of Diesel Oil and Ignition Delay Period
No full textA Transferable Force Field To Predict Phase Equilibria and Surface Tension of Ethers and Glycol Ethers
No full textCD14-159C/T polymorphism in the development of delayed skin hypersensitivity to tuberculin
Get PDFThe skin tuberculin test (TST), an example of a delayed-type hypersensitivity (DTH) reaction, is based on measuring the extent of skin induration to mycobacterial tuberculin (PPD). Little is known about the genetic basis of TST reactivity, widely used for diagnosing TB infection. The study investigated the relationship of the single base change polymorphic variants in CD14 gene (CD14(-159C/T)) with the development of DTH to PPD in BCG-vaccinated Polish Caucasian individuals. We found persistent lack of TST reactivity in about 40% of healthy subjects despite receiving more than one dose of BCG. The TST size was negatively correlated with the number of BCG inoculations. The distribution of C/T genotype was significantly more frequent among TST-negative compared with TST-positive individuals. The concentration of serum sCD14 was positively associated with mCD14 expression, but not with the TST status or CD14(-159C/T) polymorphism. A significant increase in mCD14 expression and serum sCD14 levels was found in TB group. We hypothesize that CD14(-159C/T) polymorphic variants might be one of genetic components in the response to attenuated M. bovis BCG bacilli
