2-Chloro-6,6-dimethyl-5,6-dihydro­indazolo[2,3-c]quinazoline

Two independent but virtually identical mol­ecules comprise the asymmetric unit of the title compound, C16H14ClN3. The mol­ecules have a slightly curved shape owing to puckering in the six-membered C4N2 ring; the respective dihedral angles formed between the benzene rings are 12.64 (7) and 11.72 (7)°. In the crystal, layers sustained by a combination of N—H⋯N hydrogen bonding as well as C—H⋯N and C—H⋯π contacts are formed; these stack along [011] and are connected by further C—H⋯π contacts

N-(4-Chloro­phen­yl)-1,1,1-trifluoro-N-(trifluoro­methyl­sulfon­yl)methane­sulfonamide

The title mol­ecule, also called 4-chloro-N,N-bis­(trifluoro­methane­sulfon­yl)aniline, C8H4ClF6NO4S2, has non-crystallographic twofold symmetry with the pseudo-axis aligned along the Cl—C⋯C—N backbone of the mol­ecule: the SO2CF3 residues lie to either side of the benzene ring. In the crystal, the presence of C—H⋯O contacts lead to the formation of a sequence of 12-membered {⋯HC2NSO}2 synthons within a supra­molecular chain aligned along [101]

Reductive Debromination of 1-Methyl-2,4,5-tribromoimidazole Mediated by Dry Tetramethylammonium Fluoride in Aprotic Solvents

Neste trabalho investigou-se a reação entre fluoreto de tetrametilamônio seco (TMAF) e 1-metil-2,4,5-tribromoimidazol em diferentes solventes apróticos polares. Nas reações feitas em DMSO, N,N-dimetilacetamida e N-metilpirrolidona, os principais produtos foram provenientes da desbrominação redutiva e não da fluoração, como esperado, mostrando que o TMAF é fortemente básico nestas condições. A reação feita em DMSO deuterado mostrou que o solvente é a principal fonte de próton. A dimetilformamida foi o solvente menos efetivo como doador de prótons, mas forneceu um rendimento significativo do produto fluorado 4,5-dibromo-2-flúor-1-metilimidazol. The reaction of dry tetramethylammonium fluoride (TMAF) with 1-methyl-2,4,5-tribromoimidazole in different polar aprotic solvents was investigated. Products of reductive debromination were obtained rather than fluorine substitution, indicating that TMAF is strongly basic in such conditions. A reaction carried out in d 6 -DMSO showed that the solvent is the proton source. Dimethylformamide was less effective that DMSO, N,N-dimethylacetamide or Nmethylpirrolidone as a proton donor and we were able to effect significant fluorination in this solvent

N-(4-Chlorophenyl)ethanimidamide

A twisted conformation is found in the title compound, C8H9ClN2, with the ethanimidamide residue being twisted substantially to the benzene ring [dihedral angle = 66.54 (14)°]. The conformation about the C=N double bond [1.299 (3) Å] is Z. A two-dimensional array with a zigzag topology is formed in the crystal structure via N—H...N and N—H...Cl hydrogen-bonding interactions