Maximum a posteriori estimation through simulated annealing for binary asteroid orbit determination

This paper considers a new method for the binary asteroid orbit determination problem. The method is based on the Bayesian approach with a global optimisation algorithm. The orbital parameters to be determined are modelled through an a posteriori distribution made of a priori and likelihood terms. The first term constrains the parameters space and it allows the introduction of available knowledge about the orbit. The second term is based on given observations and it allows us to use and compare different observational error models. Once the a posteriori model is built, the estimator of the orbital parameters is computed using a global optimisation procedure: the simulated annealing algorithm. The maximum a posteriori (MAP) techniques are verified using simulated and real data. The obtained results validate the proposed method. The new approach guarantees independence of the initial parameters estimation and theoretical convergence towards the global optimisation solution. It is particularly useful in these situations, whenever a good initial orbit estimation is difficult to get, whenever observations are not well-sampled, and whenever the statistical behaviour of the observational errors cannot be stated Gaussian like.Comment: Accepted for publication in Monthly Notices of the Royal Astronomical Societ

Influence of injected metoprolol and high-dosage statin therapy on some markers of early myocardial remodeling in acute coronary syndrome

Aim of the study was to evaluate of the effect of intravenous metoprolol tartrate administered before percutaneous coronary intervention (PCI), in combination with long-term use of high-dose atorvastatin, on dynamic changes in biochemical and ultrasound markers, as well as on the outcomes of early myocardial remodeling in patients with ST-segment elevation acute myocardial infarction (MI). Material and methods. A prospective randomized clinical trial included 136 patients with MI. The terms of the study were 35 ± 5 (from 30 to 40) days from the moment of admission to the hospital. The first group (control) included patients who received standard interventional and drug treatment at the hospital and outpatient post-infarction stages. The second group (exposure) included individuals who received a single intravenous injection of metoprolol tartrate before PCI, followed by a switch to oral metoprolol succinate on a systemic basis. These patients, as well as in the first group, regularly received all components of the basic drug therapy, including atorvastatin at a dose of 80 mg per day for one month from the onset of MI. On the 1st-2nd day of MI and a month later, plasma levels of biochemical biomarkers were assessed in patients; on the 1st, 10th day and one month later, ultrasound markers were evaluated using echocardiography. Upon the follow-up clinical outcomes of post-infarction myocardial remodeling were analyzed. Results. We confirmed that the use of a single intravenous injection of metoprolol tartrate (5–15 mg) in acute myocardial infarction before PCI against the background of high-dose atorvastatin (80 mg/day) for one month from the onset of myocardial infarction demonstrated convincing efficacy in relation to the prevention of early myocardial remodeling, which we assessed by the dynamics of ultrasound markers, as well as by the plasma activity of all three key biochemical markers in comparison with the control group of patients. Conclusions. The use of a single intravenous injection of metoprolol tartrate in the acute phase of MI against the background of high-dose atorvastatin for one month from the onset of MI is a highly effective pharmacological method for preventing the formation of early postinfarction myocardial remodeling

Mesenchymal stem cells in the treatment of ischemic stroke

Over the past two decades, multiple preclinical studies have shown that transplantation of mesenchymal stem cells leads to a pronounced positive effect in animals with experimental stroke. Based on the promising results of preclinical studies, several clinical trials on the transplantation of mesenchymal stem cells to stroke patients have also been conducted. In this review, we present and analyze the results of completed clinical trials dedicated to the mesenchymal stem cells transplantation in patients with ischemic stroke. According to the obtained results, it can be concluded that transplantation of mesenchymal stem cells is safe and feasible from the economic and biomedical point of view. For the further implementa-tion of this promising approach into the clinical practice, randomized, placebo-controlled, multicenter clinical trials are needed with a large sample of patients and optimized cell transplantation protocols and patient inclusion criteria. In this review we also discuss possi-ble strategies to enhance the effectiveness of cell therapy with the use of mesenchymal stem cells

Bayesian statistical approach to binary asteroid orbit determination

International audienceOrbit determination from observations is one of the classical problems in celestial mechanics. Here we present a statistical approach to banary asteroids orbit determination based on the algorithm of Monte Carlo Markov Chain (MCMC). Furthermore, the present method can be used on the orbit determination in the Gaia mission program for the observations of binary asteroids

Synthesis, X-Ray Crystal Structure, Hirshfeld Surface Analysis, and Molecular Docking Study of Novel Hepatitis B (HBV) Inhibitor: 8-Fluoro-5-(4-fluorobenzyl)-3-(2-methoxybenzyl)-3,5-dihydro-4H-pyrimido[5,4-b]indol-4-one

A method for the synthesis of 8-fluoro-5-(4-fluorobenzyl)-3-(2-methoxybenzyl)-3,5-dihydro-4H-pyrimido[5,4-b]indol-4-one has been developed and the electronic and spatial structure of a new biologically active molecule has been studied both theoretically and experimentally. The title compound was crystallized from acetonitrile and the single-crystal X-ray analysis has revealed that it exists in a monoclinic P21/n space group, with one molecule in the asymmetric part of the unit cell, a = 16.366(3) Å, b = 6.0295(14) Å, c = 21.358(4) Å, β = 105.21(2)°, V = 2033.7(7) Å3 and Z = 4. Hirshfeld surface analysis was used to study intermolecular interactions in the crystal. Molecular docking studies have evaluated the investigated compound as a new inhibitor of hepatitis B. Testing for anti-hepatitis B virus activity has shown that this substance has in vitro nanomolar inhibitory activity against Hepatitis B virus (HBV)

(2-Benzoyl-1-phenylethenolato-κ2O,O′)bis[2-(1-phenyl-1H-benzimidazol-2-yl)phenyl-κC1]iridium(III) dichloromethane disolvate

We present here synthesis and crystal structure of a neutral IrIII complex, [Ir(C19H13N2)2(C15H11O2)]·2CH2Cl2 or [Ir(C^N)2O^O]·2CH2Cl2, where C^N is 1,2-diphenyl-1H-benzimidazole and O^O is 2-benzoyl-1-phenylethenolate. The coordination sphere of the IrIII atom, located on a twofold rotation axis, is that of a slighlty distorted C2N2O2 octahedron, with the N atoms in a trans configuration. In the crystal, complex molecules assemble through weak C—H...π interactions in the range 2.699 (3)–2.892 (3) Å. The solvent CH2Cl2 molecules reside in channels aligned along the a axis and are connected to the complex molecules by C—H...O interactions

Novel One-Pot Synthesis of Methyl 4-Hydroxy-2-thioxo-1,2-dihydroquinoline-3-carboxylate: Synthetic and Crystallographic Studies

A new suitable method of synthesis of methyl 4-hydroxy-2-thioxo-1,2-dihydroquinoline-3-carboxylate by condensation of methyl 2-isothiocyanatobenzoate and methyl malonate is described. The structure of the compound both and by-product methyl 2-(methoxycarbonothioylamino)benzoate was confirmed by means of elemental analysis, 1H NMR, 13C NMR, LC/MS and single crystal X-ray diffraction. UV/Vis and IR spectra of compounds are described. The presence of a strong intramolecular hydrogen bond between the hydroxy group and the carbonyl oxygen atom of the ester group in methyl 4-hydroxy-2-thioxo-1,2-dihydroquinoline-3-carboxylate is shown. The crystal structure of product was stabilized through intermolecular hydrogen bonds