Glare of the Diamond; Botswana Why AIDS Corporate Social Responsibility Initiatives are not successful

The research aim in this paper is to outline, detail and come to a deeper understanding as to why AIDS/HIV corporate social responsibility CSR initiatives have not been truly successful in the Central District of Botswana. I will focus on the following aspects in the analysis; history, stigma, gender and traditional values, and the corporate refocus on the blood diamond movement. Botswana is a mineral rich country, and in my scope of research I look to the mining corporations that have mines in the Central district of Botswana. De Beers, Debswana are the two larger mining corporations that I draw up in my paper, but the Tati Nickel Mine and the Soda Ash Botswana mine are also mentioned within this paper due to their location, and their parallel history and social structures to De Beers and Debswana. De Beers, like many other global corporations, has had to stand up and face their involvement with the spread and continual spread of AIDS/HIV in Sub-Saharan Africa. However, in Botswana De Beers face many other issues that limit or side-track them on how much public ‘push’ and power they can do when they initiate corporate social responsibility CSR program(s) at their mines. To understand how Botswana and its’ relationship with De Beers [and other mining corporations] and the development of AIDS/HIV, a historical review is needed, for one has to understand how the social structures of mines, mining communities and out laying towns have been created under this ‘mining’ social structure. The second important issue in understanding CSR and how limited it is, in regards to De Beers, Debswana and other mining corporations, in Botswana is the high level of social issues such as stigmatization, traditional and gender issues/values that AIDS/HIV individuals, and government bodies have to deal with. The third and present issue that limits how De Beers deals with AIDS/HIV and their CSR response to SI (survival international) campaign to end the trade in Blood Diamonds, and with new mining exploration into the Gope area of the Kalaharia desert De Beers has redirected their CSR attention to something they can change and re-solve now

Do biodiversity-ecosystem functioning experiments inform stakeholders how to simultaneously conserve biodiversity and increase ecosystem service provisioning in grasslands?

Two key stakeholders primarily important for nature conservation are farmers (and their lobby groups) and conservationists. Both have substantial inputs into environmental strategies and policies calling for biodiversity conservation aimed to directly increase ecosystem services. The scientific literature concurs that as biological diversity increases so do ecosystem functions and services in grasslands. While the evidence for this is strong, the majority comes from controlled small-scale biodiversity-ecosystem functioning (BEF) experiments. Thus, it is unclear whether the scientific basis for implementing BEF relationships into practice is sufficiently evidenced. Here we explore the applicability of findings from BEF experiments to the conservation and management of temperate grassland, a widespread and potentially highly biodiverse habitat. While we acknowledge that BEF research can reveal insights into fundamental mechanisms, the saturation of biodiversity effects at low levels and unrealistic (management) treatments widely impede the applicability of these experimental results to permanent grasslands. Additionally, the integration of BEF research results into practice is considerably hampered by experimental studies not answering stakeholders' crucial questions, e.g. is there evidence of biodiversity conservation potentials? Thus, stakeholders do not have a strong evidence base for taking decisions for the addressed management goals, except intensive production in (species-poor) temporary grasslands. If BEF work is to inform stakeholders future research needs to overcome unrealistic management, missing stakeholder involvement and ineffective communication. A new generation of applied BEF experiments employing applied, multi-actor approaches is needed to facilitate the relevance of BEF research for nature conservation, agriculture and land management

Lack of trust in maternal support is associated with negative interpretations of ambiguous maternal behavior

Attachment theory assumes that children who lack trust in maternal availability for support are more inclined to interpret maternal behavior in congruence with their expectation that mother will remain unavailable for support. To provide the first test of this assumption, early adolescents (9-13 years old) were asked to assess whether ambiguous interactions with mother should be interpreted in a positive or a negative way. In our sample (n = 322), results showed that early adolescents' lack of trust in their mother's availability for support was related to more negative interpretations of maternal behavior. The associations remained significant after controlling for depressive mood. The importance of these findings for our understanding of attachment theory, attachment stability, and clinical practice are discussed

Circumgalactic Medium on the Largest Scales: Detecting X-ray Absorption Lines with Large-Area Microcalorimeters

The circumgalactic medium (CGM) plays a crucial role in galaxy evolution as it fuels star formation, retains metals ejected from the galaxies, and hosts gas flows in and out of galaxies. For Milky Way-type and more massive galaxies, the bulk of the CGM is in hot phases best accessible at X-ray wavelengths. However, our understanding of the CGM remains largely unconstrained due to its tenuous nature. A promising way to probe the CGM is via X-ray absorption studies. Traditional absorption studies utilize bright background quasars, but this method probes the CGM in a pencil beam, and, due to the rarity of bright quasars, the galaxy population available for study is limited. Large-area, high spectral resolution X-ray microcalorimeters offer a new approach to exploring the CGM in emission and absorption. Here, we demonstrate that the cumulative X-ray emission from cosmic X-ray background sources can probe the CGM in absorption. We construct column density maps of major X-ray ions from the Magneticum simulation and build realistic mock images of nine galaxies to explore the detectability of X-ray absorption lines arising from the large-scale CGM. We conclude that the OVII absorption line is detectable around individual massive galaxies at the $3\sigma-6\sigma$ confidence level. For Milky Way-type galaxies, the OVII and OVIII absorption lines are detectable at the $\sim\,6\sigma$ and $\sim\,3\sigma$ levels even beyond the virial radius when co-adding data from multiple galaxies. This approach complements emission studies, does not require additional exposures, and will allow probing of the baryon budget and the CGM at the largest scales.Comment: 16 pages, 8 figures, accepted for publication in Ap

Rare mutations in SQSTM1 modify susceptibility to frontotemporal lobar degeneration

Mutations in the gene coding for Sequestosome 1 (SQSTM1) have been genetically associated with amyotrophic lateral sclerosis (ALS) and Paget disease of bone. In the present study, we analyzed the SQSTM1 coding sequence for mutations in an extended cohort of 1,808 patients with frontotemporal lobar degeneration (FTLD), ascertained within the European Early-Onset Dementia consortium. As control dataset, we sequenced 1,625 European control individuals and analyzed whole-exome sequence data of 2,274 German individuals (total n = 3,899). Association of rare SQSTM1 mutations was calculated in a meta-analysis of 4,332 FTLD and 10,240 control alleles. We identified 25 coding variants in FTLD patients of which 10 have not been described. Fifteen mutations were absent in the control individuals (carrier frequency < 0.00026) whilst the others were rare in both patients and control individuals. When pooling all variants with a minor allele frequency < 0.01, an overall frequency of 3.2 % was calculated in patients. Rare variant association analysis between patients and controls showed no difference over the whole protein, but suggested that rare mutations clustering in the UBA domain of SQSTM1 may influence disease susceptibility by doubling the risk for FTLD (RR = 2.18 [95 % CI 1.24-3.85]; corrected p value = 0.042). Detailed histopathology demonstrated that mutations in SQSTM1 associate with widespread neuronal and glial phospho-TDP-43 pathology. With this study, we provide further evidence for a putative role of rare mutations in SQSTM1 in the genetic etiology of FTLD and showed that, comparable to other FTLD/ALS genes, SQSTM1 mutations are associated with TDP-43 pathology