Response versus features extracted from the WM composite image.

<p>Response versus features extracted from the WM composite image.</p

Interpreting the properties of skewness and kurtosis in histograms.

<p>Interpreting the properties of skewness and kurtosis in histograms.</p

Response versus features extracted from the GM composite image.

<p>Response versus features extracted from the GM composite image.</p

Multiple regression results for the prediction of the response to therapy using imaging features.

<p>Multiple regression results for the prediction of the response to therapy using imaging features.</p

Response versus features extracted from the CSF composite image.

<p>Response versus features extracted from the CSF composite image.</p

Comparison of image histogram in different tissues in responders and non-responders.

<p>Average histograms of GM image (left), WM image (middle), and CSF image (right) for non-responders (top row) and responders (bottom row).</p

Three different cases of neighborhood between Gd-enhanced area and necrosis.

<p>a) Gd-enhanced area is not fully adjacent to necrosis (Patient ID: 969). b) Gd-enhanced area contains necrosis and there is complete adjacency (Patient ID: 852). c) There is no necrosis (Patient ID: 178).</p

Tumor volumes and treatment effects on the tumors and time lengths between acquisitions as well as survival length.

<p>Tumor volumes before bevacizumab treatment as well as relative changes in the Gd-enhancement, edema, and necrosis, between baseline MRI and the one acquired about 2–3 months after the treatment, calculated by (<i>V</i>₁−<i>V</i>₂)/<i>V</i>₁, length of time between two image acquisitions, and survival times of the patients.</p><p>(*:tumors without necrosis or those with minimal adjacency of Gd-enhanced and necrotic areas).</p

Correlation coefficients between the features used in the multiple regression analysis.

<p>Correlation coefficients between the features used in the multiple regression analysis.</p

Comparison of the actual responses and estimates responses using Leave-One-Out method.

<p>Responses estimated using leave-one-out and the five features in the last row of <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029945#pone-0029945-t005" target="_blank">Table 5</a> (red columns) compared to actual results (blue columns). The relative change in the size of the Gd-enhanced region was used as the measure of response. The horizontal axis shows the patient that has been eliminated in leave-one-out analysis.</p