(Triphenyl­phosphine-κP)[1,1,1-tris­(diphenyl­phosphinometh­yl)ethane-κ3 P,P′,P′′]copper(I) tetra­fluoridoborate

In the title mononuclear CuI complex, [Cu(C18H15P)(C41H39P3)]BF4, the cation has a basic rigid core structure reminiscent of the framework of diamond. The metal atom is coordinated by four P atoms in a distorted tetra­hedral geometry, the distortion arising from the steric hindrance of the phenyl groups. The anion is disordered over two positions, with an occupancy ratio of 0.524 (17):0.476 (17). The cations and anions are closely packed in the crystal and are in h.c.p. arrangements

Measurement of Protein-Ligand Binding Constants from Reaction-Diffusion Concentration Profiles

Protein-ligand dissociation constants, lid, are determined precisely and down to the picomolar range from reaction-diffusion (RI)) concentration profiles created by proteins diffusing through hydrogels functionalized with protein ligands. The RD process effectively amplifies the molecular-scale binding events into macroscopic patterns visible to the naked eye. The method is applicable to various protein-ligand pairs and does not require any prior knowledge about the protein structure