Scalable dissolution-dynamic nuclear polarization with rapid transfer of a polarized solid

In Dissolution-Dynamic Nuclear Polarization, nuclear spins are hyperpolarized at cryogenic temperatures using radicals and microwave irradiation. The hyperpolarized solid is dissolved with hot solvent and the solution is transferred to a secondary magnet where strongly enhanced magnetic resonance signals are observed. Here we present a method for transferring the hyperpolarized solid. A bullet containing the frozen, hyperpolarized sample is ejected using pressurized helium gas, and shot into a receiving structure in the secondary magnet, where the bullet is retained and the polarized solid is dissolved rapidly. The transfer takes approximately 70 ms. A solenoid, wound along the entire transfer path ensures adiabatic transfer and limits radical-induced low-field relaxation. The method is fast and scalable towards small volumes suitable for high-resolution nuclear magnetic resonance spectroscopy while maintaining high concentrations of the target molecule. Polarization levels of approximately 30% have been observed for 1-13C-labelled pyruvic acid in solution

Dataset for Scalable Dissolution-Dynamic Nuclear Polarization with Rapid Transfer of a Polarized Solid

Unprocessed NMR data, oscilloscope traces, and time-dependent temperature data as shown in Nature Communications manuscript: Karel Kouril, Hana Kourilova, Samuel Bartram, Malcolm H Levitt, Benno Meier &#39;Scalable Dissolution-Dynamic Nuclear Polarization with Rapid Transfer of a Polarized Solid&#39;, Nature Communications </span

Hyperpolarized fumarate <i>via</i> parahydrogen

We produce hyperpolarized [1-13C]fumarate in the proton nuclear spin singlet state by pairwise trans-addition of parahydrogen to a molecular precursor using a ruthenium-based catalyst in water. The proton singlet state is transformed into observable carbon magnetization by radiofrequency pulses to enhance the 13C signal by a factor of 1000 using 50% para-enriched hydrogen gas

Spin-isomer conversion of water at room temperature, and quantum-rotor-induced nuclear polarization, in the water-endofullerene H2​​​O​@C60

Water exists in two forms, para and ortho, that have nuclear spin states with different symmetries. Here we report the conversion of fullerene-encapsulated para-water to ortho-water. The enrichment of para-water at low temperatures is monitored via changes in the electrical polarizability of the material. Upon rapid dissolution of the material in toluene the excess para-water converts to ortho-water. In H216O@C60 the conversion leads to a slow increase in the NMR signal. In H217O@C60 the conversion gives rise to weak signal enhancements attributed to quantum-rotor-induced nuclear spin polarization. The time constants for the spin-isomer conversion of fullerene-encapsulated water in ambient temperature solution are estimated as 30±4 s for the 16O-isotopologue of water, and 16±3 s for the 17O-isotopologue