Environmental benzene exposure assessment for parent-child pairs in Rouen, France

International audienceThere is a lack of data on environmental benzene exposure in children. In this study, we compared personal benzene exposure and inhalation uptake in a group of children to those of their parents. We also compared levels of urinary benzene metabolites, trans, trans-muconic acid (MA) and hydroquinone (HQ), for those two groups, and assessed the correlation between personal benzene exposure and urinary MA and HQ concentrations. The study was performed on 21, 2-3-year-old children and their parents recruited on a voluntary basis among non-smokers from the three largest day-care centers of the town of Rouen in France. Average benzene concentrations were measured over 5 consecutive days with diffusive. samplers. The following simultaneous measurements were carried out: personal exposure of the parents, concentrations inside and outside the day care centers, and inside the volunteer's bedrooms. Morning and evening urine samples were collected during the same period. Benzene personal exposure levels were 14.4 +/- 7.7 mug/m(3) and 11.09 +/- 6.15 mug/m(3) in parents and children, respectively. Benzene inhalation uptake estimates were 2.51 +/- 1.23 mug/kg/day in the group of parents and 5.68 +/- 3.17 mug/kg/day in the group of children. Detectable levels of MA and HQ were found in 85% and 100% of the samples, respectively. Intra-individual variation of urinary MA and HQ concentrations expressed as a coefficient of variation (CV) ranged from 63 to 232% and from 13 to 144%, respectively. Mean values of MA and HQ (in mg/g creatinine) were 1.6- and 1.8-fold higher in the group of children than in the group of parents (P=0.008 and P<0.0001, respectively). Significant correlations between metabolites levels and benzene were not found

Risk assessment of sensory irritants in Indoor air - A case study in a French School

International audienceExposure to airborne pollutants can result in adverse health effects. Acute symptoms can for instance comprise of irritation of the eyes or of the respiratory tract (called sensory irritation). In a recent case, health problems were reported in a French school and supposedly attributed to the presence of airborne irritant pollutants. Based on measured concentrations, the risk of developing the described health effects was assessed. Numerous airborne sensory irritants (aldehydes, organic acids, volatile organic compounds (VOCs), SO2, NH3) were identified and quantified in the indoor air by using active and passive sampling and online monitoring techniques. Reference values based on toxicological properties of compounds (sensory irritants) were taken from the literature. If not available, tentative values were specialty developed for this purpose. Concentrations of all sensory irritants remain below their corresponding guideline values and are comparable to literature data. It was concluded that the risk of developing sensory irritation due to the presence of the studied compounds is negligible. This holds both for individual compounds and for the mixture of studied compounds. Limitations of the employed sampling strategy, and of existing sampling and analytical techniques, which do not allow for analysing more reactive compounds-which are strong sensory irritants-may play a role. New sampling techniques need to be developed. Psychosocial factors (group behaviour, increased attention to sensory irritation) should also be taken into account when dealing with health complaints on sensory irritation

INERIS work on glycol ethers

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Application de la démarche d'évaluation des risques sanitaires aux polluants chimiques de l'environnement intérieur

La connaissance de la relation santé-environnement est devenue un enjeu majeur de santé publique. Une fraction importante des pathologies chroniques (cancers, pathologies respiratoires, allergies, atteintes de la reproduction...), dont l'incidence est pour certaines en augmentation, apparaît, en effet, être la conséquence de l'action de facteurs environnementaux (Baldwin, 1996). Ceux-ci restent encore très largement à identifier. La relation entre pollution de l'environnement intérieur et santé a historiquement surtout été abordée sous l'angle santé-travail, à partir notamment d'effets du type " Syndrome des Bâtiments Malsains ". La relation avec les pathologies chroniques a été moins étudiée