珪肺症における血清過酸化脂質測定意義に関する研究

取得学位 : 博士（医学）, 学位授与番号 : 医博乙第1342号, 学位授与年月日：平成7年6月21日,学位授与年：199

Bovine Myoblast Differentiation

Satellite cells are involved in postnatal myogenesis and in muscle hypertrophy. A better understanding of the mechanisms of myogenesis is useful to improve the muscle production in farm animals. Herein, we show the cytokine effects on the myogenesis in bovine myoblast cultures. Acidic fibroblast growth factors (aFGF) and interleukin 1 (IL-1) stimulated the cell proliferation, and insulin-1ike growth factor-I (IGF-I) stimulated to form multinucleated myotubes. Thus, it was possible to regulate the bovine myoblast differentiation by aFGF, IL-1 and/or IGF-I. Using the culture system, the expression of myosin heavy chain (MyHC) isoforms was detailed in bovine myoblasts during the differentiation. It was immunohistochemically confirmed that bovine myoblasts expressed β/slow-type MyHC (MyHC-slow), fast-type MyHC (MyHC-fast) and developmental-type MyHC (MyHC-dev) isoforms. Furthermore, the expression of fast 2a and β/slow MyHC mRNA was recognized in the cultures of bovine myoblasts. The results support the existence of bovine myoblast phenotypes that express differentially MyHC isoforms

Hyperfine Structure of the Electron Spin Resonance of Phosphorus-Doped Si Nanocrystals

Electronic states of P donors in Si nanocrystals (nc-Si) embedded in insulating glass matrices have been studied by electron spin resonance. Doping of P donors into nc-Si was demonstrated by the observation of optical absorption in the infrared region due to intraconduction band transitions. P hyperfine structure (hfs) was successfully observed at low temperatures. The observed splitting of the hfs was found to be much larger than that of the bulk Si:P and depended strongly on the size of nc-Si. The observed strong size dependence indicates that the enhancement of the hyperfine splitting is caused by the quantum confinement of P donors in nc-Si

The decomposition of level-1 irreducible highest weight modules with respect to the level-0 actions of the quantum affine algebra Uq′(sl^n)U'_q(\hat{sl}_n)

We decompose the level-1 irreducible highest weight modules of the quantum affine algebra $U_q(\hat{sl}_n)$ with respect to the level-0 $U'_q (\hat{sl}_n)$--action defined in q-alg/9702024. The decomposition is parameterized by the skew Young diagrams of the border strip type.Comment: 22 pages, AMSLaTe

MGMT promoter methylation and temozolomide response in choroid plexus carcinoma

Choroid plexus carcinoma (CPC) is a malignant tumor with a strong tendency to spread along the cerebrospinal fluid pathway. There is no standardized chemotherapy protocol for this rare tumor. We report a 38-year-old man with CPC in the lateral ventricle with obstructive hydrocephalus. Because of the poor demarcation between thalamus and fornix, subtotal tumor resection was performed. Postoperative spine magnetic resonance (MR) image revealed whole spinal axis dissemination. After diagnosis of CPC, the patient was treated with whole ventricular and spine radiation concomitant with temozolomide chemotherapy, although the O 6-methylguanine-DNA methyltransferase (MGMT) promoter was found to be unmethylated. Although MR images revealed transient stable disease during adjuvant therapy, tumor progression was depicted after four cycles of temozolomide therapy. We discuss the ineffectiveness of adjuvant temozolomide therapy for CPC in connection with O 6-methylguanine-DNA methyltransferase promoter methylation. © 2011 The Japan Society of Brain Tumor Pathology

Prediction of carotid artery in-stentrestenosis by quantitative assessment ofvulnerable plaque using computed tomography

Background and purpose To assess the relationship between plaque volume evaluated by multidetector computed tomographic angiography (MDCT) and in-stent restenosis (ISR) after carotid artery stenting (CAS). Materials and methods From a retrospectively maintained database, data were collected for 52 patients with carotid artery stenosis treated with CAS between 2007 and 2012. We defined ISR of ≥ 50% as a peak systolic velocity ≥ 200 cm/s on echo-duplex scan. Carotid plaques were subdivided into four components according to radiodensity in Hounsfield units (HU) as follows: 600 HU. Risk factors that influenced ISR were compared using univariate and multivariate Cox regression analyses. Results During a median follow-up period of 36 months, ISR of ≥ 50% was detected in five patients (9.6%). In the univariate Cox proportional hazard regression analysis, renal insufficiency, coronary artery disease, total plaque volume, and plaque volumes with radiodensities < 0 and ≥ 600 HU increased the risk for ISR (P < 0.10). When the significant risk factors determined from the univariate analysis were subjected to a multivariate analysis, only the volumes of the plaque components with radiodensities < 0 HU independently predicted the development of ISR (hazard ratio: 1.041; 95% confidence interval: 1.006–1.078; P = 0.021). Conclusion Our data suggest that the high volume of the plaque components with radiodensities < 0 HU was independently associated with the increased risk of ISR after CAS. Quantitative and qualitative tissue characterizations of carotid plaques using MDCT might be a useful predictive tool of the development of ISR.Embargo Period 12 month

A Case of Intraductal Papillary Neoplasm of the Bile Duct with Stromal Invasion

Intraductal papillary neoplasm of the bile duct (IPNB) represents biliary papillary tumors mainly growing and is considered to be of relatively low-grade malignancy. Here we report a case of IPNB in whom the poorly differentiated component deeply infiltrated the bile duct wall. A 77-year-old male had an invasive carcinoma of the bile duct 3 cm in size. He underwent right hemihepatectomy with combined resection of the extrahepatic bile duct. Papillary growing tumor was observed in the common bile duct and the right posterior Glisson's pedicle was invaded. Histologic finding showed papillary adenocarcinoma in the surface layer superficially extending to the epithelium of the surrounding bile duct. In the subserosal layer, the tumor represented poorly differentiated adenocarcinoma. The tumor was diagnosed as invasive bile duct carcinoma arising from IPNB