9 research outputs found

    Protection of 5′‐Hydroxy Functions of Nucleosides

    No full text
    The 5‐hydroxy group is the primary hydroxy group of nucleosides. It is mandatory to protect 5‐hydroxyls in all methods of oligonucleotide synthesis that require nucleoside synthons. This unit discusses a wide variety of acid‐labile and base‐labile protecting groups, as well as enzymatic methods for 5‐protection and deprotection.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/143732/1/cpnc0203.pd
    corecore