Характеристика лекарственно-индуцированных кожных реакций в многопрофильном скоропомощном стационаре

This prospective study was carried out in a period of 1 year on the basis of the multifield emergency hospital in the departments of therapy, urology and purulent surgery. On the basis of data of the screening method and the method of spontaneous messages a group of 347 patients with skin reactions, which potentially associated with the intake of medicines was highlighted in. Among them, there were 179 patients with non drug associated skin reactions and 168 patients with drug-induced skin reactions. The most common cutaneous drug reactions (CDR) were: acute urticaria, angioedema; drug toxidermia; allergic dermatitis; hemorrhagic vasculitis. Mostly СDR were caused by the following groups of drugs: b-lactam antibiotics; fluoroquinolones; drugs, improving cerebral blood flow; rentgencontrasting substances.Настоящее проспективное исследование осуществлялось в течение 1 года на базе многопрофильного скоропомощного стационара в отделениях терапии, урологии и гнойной хирургии. На основании данных скринингового метода и метода спонтанных сообщений была выделена группа пациентов количеством 347 человек с кожными реакциями, потенциально связанными с приемом лекарственных средств. Среди них было 179 пациентов c кожными реакциями, не связанными с приемом лекарственных средств (ЛС) и 168 пациентов с лекарственно-индуцированными кожными реакциями. Наиболее распространенными кожными лекарственными реакциями (КЛР) были: острая крапивница, отек Квинке; лекарственные токсидермии; аллергические дерматиты; геморрагические васкулиты. Чаще всего КЛР вызывали следующие группы ЛС: b-лактамные антибиотики; фторхинолоны; ЛС, улучшающие мозговой кровоток; рентгеноконтрастные вещества

Возможности количественного сенсорного тестирования для оценки состояния тонких волокон у пациентов с компрессионной радикулопатией на пояснично-крестцовом уровне

Surveyed 55 patients with clinical displays of neuropathic pain syndrome in consequence of compression radiculitis L5, S1 which has been proved by MRT/CT and pain questionnaires. Quantitative sensory testing (QST) was performed to assess loss of sensory function for two dermatome body areas (one affected and normal area): thermal detection thresholds for the perception of cold and warm, thermal pain thresholds for cold and warm stimuli. The results showed dysfunction of small fibers on affected low limb and unaffected low limb. There also were founded combination of cold hyperalgesia and allodinia and closely correlation of QST-parameters with questionnaires results.Обследовано 55 пациентов с клинической картиной невропатического болевого синдрома вследствие компрессионной радикулопатии L5, S1 корешков, подтвержденной данными клинико-неврологического обследования, МРТ/КТ исследований и опросников боли. Метод количественного сенсорного тестирования (КСТ) применялся для оценки сенсорной функции по дерматомам с двух сторон (на вовлеченной в болевой процесс нижней конечности и на невовлеченной): определялись температурные пороги тепловой чувствительности, холодовой чувствительности, тепловой и холодовой боли). Полученные результаты свидетельствуют о дисфункции тонких волокон как на вовлеченной в болевой процесс нижней конечности, так и на невовлеченной. Также отмечено сочетание холодовой гипералгезии с аллодинией, тесная корреляция результатов количественного тестирования с данными опросников боли

Ambulatory methods of blood pressure measurement in clinical practice

[No abstract available

Achievements and problems of modern trials of antihypertensive drugs

Most important value of lowering of substantially elevated arterial pressure (AP) for improvement of outcomes in patients with arterial hypertension (AH) was convincingly confirmed by large truly placebo controlled randomized clinical trials (RCT) with the use of mainly diuretics, and/or (i-adrenoblockers in the 6O-80ths. Later comparative RCT confirmed equal antihypertensive efficacy of 5 main drug classes relative to AP level in brachial artery. In this review we discuss merit of auxiliary class-specific properties of antihypertensive agents potentially affecting prognosis besides AP lowering. We also discuss problems related to decline of significance of quantitative criteria of AH and consideration of AP level in general context of cardiovascular risk; problems of external validity of RCT; extrapolation of RCT results obtained in patients with complicated AH and very high cardiovascular risk on young patients with uncomplicated AH; significance of hard and surrogate end points

European guidelines on hypertension in 2013: Unchanging, New, Unsolved

[No abstract available

Achievements and problems of modern trials of antihypertensive drugs

Most important value of lowering of substantially elevated arterial pressure (AP) for improvement of outcomes in patients with arterial hypertension (AH) was convincingly confirmed by large truly placebo controlled randomized clinical trials (RCT) with the use of mainly diuretics, and/or (i-adrenoblockers in the 6O-80ths. Later comparative RCT confirmed equal antihypertensive efficacy of 5 main drug classes relative to AP level in brachial artery. In this review we discuss merit of auxiliary class-specific properties of antihypertensive agents potentially affecting prognosis besides AP lowering. We also discuss problems related to decline of significance of quantitative criteria of AH and consideration of AP level in general context of cardiovascular risk; problems of external validity of RCT; extrapolation of RCT results obtained in patients with complicated AH and very high cardiovascular risk on young patients with uncomplicated AH; significance of hard and surrogate end points

Ambulatory methods of blood pressure measurement in clinical practice

[No abstract available

European guidelines on hypertension in 2013: Unchanging, New, Unsolved

[No abstract available

Characteristics of central pulse wave in young men with various phenotypes of arterial pressure

In this work we compared parameters of central arterial pressure (AP) on the basis of analysis of pulse wave in young men in dependence of AP phenotype determined by repetitive clinical measurements and 24 hour AP monitoring (24HAPM). Comparison of characteristics of central pulse wave was carried out in 12 men with normal AP, 36 men with arterial hypertension (AH) according to clinical measurements and 24HAPM, and 17 men with white coat hypertension (WCH). Mean age was 21.0±2.1 years. Differences in levels of pulse pressure (PP) between groups with AH were revealed only at the level of the aorta. Studied patients with normal AP and 24HAPM did not differ by such characteristics as index of increment and reflected wave appearance time. Studied patients with AH confirmed by 24HAPM were characterized by significantly greater augmentation of central PP (100.0±12.6% vs 96.6±11.8% in persons with normal AP and 95.6±15.0% with WCH, p<0.05), earlier appearance of reflected wave (149.2±18.9 ms vs 160.6±16.2 and 160.3±28.6 ms, respectively, p<0.05), high rate of pulse wave propagation (8.6±1.2 m/s vs 7.2±1,2 and 7.0±1.7 m/s). Amplification was similar in three groups. The data obtained has shown that in men aged 18-25 years presence of AH, confirmed by 24HAPM) is associated with elevation of central systolic AP and PP and higher values of markers of both rigidity of the aorta and remodeling of peripheral vascular bed

Combination therapy of arterial hypertension: Role of triple combinations

[No abstract available