1 research outputs found
Ground-State Elevation Approach To Suppress Side Reactions in Gold-Sensing Systems Based on Alkyne Activation
A novel approach to suppress the
side reactions observed in the
reaction-based gold-sensing systems based on the alkyne activation
is disclosed. By elevating steric strain around the reaction site,
the gold ion promoted ring-opening process in rhodamine-lactam probes
is significantly accelerated, which also leads to suppression of those
possible side reactions. As a result, the probes show very high sensitivity
in addition to excellent selectivity toward gold species. Furthermore,
bioimaging of gold species in live cells was demonstrated with a FRET
version