31 research outputs found
First light demonstration of the integrated superconducting spectrometer
Ultra-wideband 3D imaging spectrometry in the millimeter-submillimeter
(mm-submm) band is an essential tool for uncovering the dust-enshrouded portion
of the cosmic history of star formation and galaxy evolution. However, it is
challenging to scale up conventional coherent heterodyne receivers or
free-space diffraction techniques to sufficient bandwidths (1 octave) and
numbers of spatial pixels (>). Here we present the design and first
astronomical spectra of an intrinsically scalable, integrated superconducting
spectrometer, which covers 332-377 GHz with a spectral resolution of . It combines the multiplexing advantage of microwave kinetic
inductance detectors (MKIDs) with planar superconducting filters for dispersing
the signal in a single, small superconducting integrated circuit. We
demonstrate the two key applications for an instrument of this type: as an
efficient redshift machine, and as a fast multi-line spectral mapper of
extended areas. The line detection sensitivity is in excellent agreement with
the instrument design and laboratory performance, reaching the atmospheric
foreground photon noise limit on sky. The design can be scaled to bandwidths in
excess of an octave, spectral resolution up to a few thousand and frequencies
up to 1.1 THz. The miniature chip footprint of a few
allows for compact multi-pixel spectral imagers, which would enable
spectroscopic direct imaging and large volume spectroscopic surveys that are
several orders of magnitude faster than what is currently possible.Comment: Published in Nature Astronomy. SharedIt Link to the full published
paper: https://rdcu.be/bM2F
Efficacy of salvage therapies for advanced acral melanoma after anti-PD-1 monotherapy failure: a multicenter retrospective study of 108 Japanese patients
BackgroundAnti-programmed cell death protein 1 (PD-1) monotherapy is one of the standard systemic therapies for advanced melanoma; however, the efficacy of salvage systemic therapies after PD-1 monotherapy failure (PD-1 MF), particularly in acral melanoma (AM), the main clinical melanoma type in Japanese patients, is unclear. This study aimed to investigate the efficacy of salvage systemic therapies in Japanese patients with AM after PD-1 MF.Patients and methodsThe study included 108 patients with advanced AM (palm and sole, 72; nail apparatus, 36) who underwent salvage systemic therapy at 24 Japanese institutions. We mainly assessed the objective response rate (ORR), progression-free survival (PFS), and overall survival (OS).ResultsThirty-six (33%) patients received ipilimumab, 23 (21%) received nivolumab and ipilimumab (nivo/ipi), 10 (9%) received cytotoxic chemotherapy, 4 (4%) received BRAF and MEK inhibitors (BRAFi/MEKi), and the remaining 35 (32%) continued with PD-1 monotherapy after disease progression. The ORRs in the ipilimumab, nivo/ipi, cytotoxic chemotherapy, and BRAFi/MEKi groups were 8, 17, 0, and 100%, respectively. The nivo/ipi group showed the longest OS (median, 18.9 months); however, differences in ORR, PFS, and OS between the groups were insignificant. The OS in the nivo/ipi group was higher in the palm and sole groups than in the nail apparatus group (median: not reached vs. 8.7 months, p < 0.001). Cox multivariate analysis demonstrated that nail apparatus melanoma independently predicted unfavorable PFS and OS (p = 0.006 and 0.001). The total OS (from PD-1 monotherapy initiation to death/last follow-up) was insignificant between the groups.ConclusionNivo/ipi was not more effective than cytotoxic chemotherapy and ipilimumab after PD-1 MF in patients with advanced AM. The prognosis after PD-1 MF would be poorer for nail apparatus melanoma than for palm and sole melanoma