95 research outputs found
Toward the Precise Control of Cell Differentiation Processes by Using Micro and Soft Lithography
Noninvasive Positive Pressure Ventilation against Reperfusion Pulmonary Edema following Percutaneous Transluminal Pulmonary Angioplasty
A 69-year-old man with chronic thromboembolic pulmonary hypertension (CTEPH) was on amblatory oxygen inhalation therapy (3 L/min) and scheduled for percutaneous transluminal pulmonary angioplasty (PTPA). The patient's New York Heart Association functional status was class III with recent worsening of dyspnea and apparent leg edema. Transthoracic echocardiography revealed right ventricular enlargement with mean pulmonary artery pressure of 42 mmHg. After PTPA, he was complicated with postoperative reperfusion pulmonary edema, and noninvasive positive pressure ventilation (NPPV) was applied immediately. Hypoxemia was successfully treated with 15 days of NPPV. Although mean pulmonary artery pressure was unchanged, his brain natriuretic peptide level decreased from preoperative 390.3 to postoperative 44.3 pg/dL. In addition, total pulmonary resistance decreased from preoperative 18 to postoperative 9.6 wood unit·m2. The patient was discharged on day 25 with SpO2 of 95% on 5 L/min of oxygen inhalation. Because pulmonary edema is a postsurgical life-threatening complication following PTPA, application of NPPV should be considered
Partial Catalytic Domains of New Protein-tyrosine Kinases Cloned from cDNA Amplified by Polymerase Chain Reaction
A feature common to all members of the protein-tyrosine kinase (PTK) family is a highly conserved catalytic domain which is characteristic of this group. Degenerate oligonucleotide primers corresponding to two of the most highly conserved regions of the PTK catalytic domain were designed to amplify cDNA sequences of restricted subfamilies of PTKs from rat brain mRNA in the polymerase chain reaction (PCR). A third degenerate oligonucleotide primer corresponding to a highly conserved, PTK subfamily-specific sequence located between the two sequences mentioned above was also used to amplify cDNA sequences of PTKs of novel subfamilies from rat brain mRNA. pBluescript PCR libraries were constructed from the PCR-amplified cDNA. The PCR libraries were then screened by DNA sequencing for PTK-related sequences. Several sequences were identified that, on the basis of sequence comparison with known PTKs in GenBank, may encode new PTKs
Thermodynamic properties of small flares in the quiet Sun observed by H and EUV: plasma motion of the chromosphere and time evolution of temperature/emission measure
Small flares frequently occur in the quiet Sun. Previous studies have noted
that they share many common characteristics with typical solar flares in active
regions. However, their similarities and differences are not fully understood,
especially their thermal properties. In this study, we performed imaging
spectroscopic observations in the H line taken with the Solar Dynamics
Doppler Imager on the Solar Magnetic Activity Research Telescope (SMART/SDDI)
at the Hida Observatory and imaging observations with the Atmospheric Imaging
Assembly onboard Solar Dynamics Observatory (SDO/AIA). We analysed 25 cases of
small flares in the quiet Sun over the thermal energy range of
, paying particular attention to their thermal
properties. Our main results are as follows: (1) We observe a redshift together
with line centre brightening in the H line associated with more than
half of the small flares. (2) We employ differential emission measure analysis
using AIA multi-temperature (channel) observations to obtain the emission
measure and temperature of the small flares. The results are consistent with
the Shibata & Yokoyama (1999, 2002) scaling law. From the scaling law, we
estimated the coronal magnetic field strength of small flares to be 5 --15 G.
(3) The temporal evolution of the temperature and the density shows that the
temperature peaks precede the density peaks in more than half of the events.
These results suggest that chromospheric evaporations/condensations play an
essential role in the thermal properties of some of the small flares in the
quiet Sun, as does for large flares.Comment: 14 pages, 12 figures, accepted for publication in MNRA
Unified Relationship between Cold Plasma Ejections and Flare Energies Ranging from Solar Microflares to Giant Stellar Flares
We often find spectral signatures of chromospheric cold plasma ejections
accompanied by flares in a wide range of spatial scales in the solar and
stellar atmospheres. However, the relationship between physical quantities
(such as mass, kinetic energy, and velocity) of cold ejecta and flare energy
has not been investigated in a unified manner for the entire range of flare
energies to date. This study analyzed the spectra of cold plasma ejections
associated with small-scale flares and solar flares (energy
) to supply smaller energy samples. We performed
H imaging spectroscopy observation by the Solar Dynamics Doppler Imager
on the Solar Magnetic Activity Research Telescope (SMART/SDDI). We determined
the physical quantities of the ejecta by cloud model fitting to the H
spectrum. We determined flare energy by differential emission measure analysis
using Atmospheric Imaging Assembly onboard Solar Dynamics Observatory (SDO/AIA)
for small-scale flares and by estimating the bolometric energy for large-scale
flares. As a result, we found that the ejection mass and the total flare
energy follow a relation of . We show that the scaling law derived from a simple
physical model explains the solar and stellar observations with a coronal
magnetic field strength as a free parameter. We also found that the kinetic
energy and velocity of the ejecta correlate with the flare energy. These
results suggest a common mechanism driven by magnetic fields to cause cold
plasma ejections with flares on the Sun and stars.Comment: 23 pages, 10 figures; accepted for publication in Ap
The first Japanese MDPL case
Mandibular hypoplasia, deafness, progeroid features and lipodystrophy (MDPL) syndrome is a rare autosomal dominant disorder caused by heterozygous POLD1 mutations. To date, 13 patients affected by POLD1 mutation-caused MDPL have been described. We report a clinically undiagnosed 11-year-old male who noted joint contractures at 6 years of age. Targeted exome sequencing identified a known POLD1 mutation [NM_002691.3:c.1812_1814del, p.(Ser605del)] that diagnosed him as the first Japanese/East Asian MDPL case
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