96 research outputs found
Fabrication method of Yb based Oxide matrix for CMC
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Advances and technical challenges in development of CMC
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Tumor-dependent secretion of close homolog of L1 results in elevation of its circulating level in mouse model for human lung tumor
Close homolog of L1 (CHL1) and its truncated form mainly play crucial roles in mouse brain development and neural functions. Herein, we newly identified that truncated form of CHL1 is produced and released from lung tumor tissue in a mouse model expressing human EML4-ALK fusion gene. Both western blot and direct ELISA analysis revealed that mouse CHL1 level in serum (including serum extracellular vesicles) was significantly elevated in EML4-ALK transgenic mice. The correlation between the tumor size and the amount of CHL1 secretion could be examined in this study, and showed a significant positive correlation in a tumor size-dependent manner. Considering these results, the measurement of circulating CHL1 level may contribute to assess a tumor progression in human lung tumor patients
Case Report Successful Erlotinib Treatment for a Patient with Gefitinib-Related Hepatotoxicity and Lung Adenocarcinoma Refractory to Intermittently Administered Gefitinib
A 73-year-old Japanese man was histologically diagnosed with lung adenocarcinoma harboring an exon 19 deletion in the epidermal growth factor receptor. The patient was treated with gefitinib for 6 weeks until he developed substantially elevated hepatic enzyme levels that resulted in the discontinuation of gefitinib. Gefitinib was reintroduced with an intermittent treatment schedule after the transaminase levels normalized, but the patient's enzyme levels rose again, and the cancer progressed. Gefitinib was eventually replaced with erlotinib. There was stable disease for 7 weeks without any signs of liver toxicity. Thus, erlotinib may be a beneficial and well-tolerated treatment option for patients with gefitinib-related hepatotoxicity
Direct Imaging Explorations for Companions around Mid-Late M Stars from the Subaru/IRD Strategic Program
The Subaru telescope is currently performing a strategic program (SSP) using
the high-precision near-infrared (NIR) spectrometer IRD to search for
exoplanets around nearby mid/late-M~dwarfs via radial velocity (RV) monitoring.
As part of the observing strategy for the exoplanet survey, signatures of
massive companions such as RV trends are used to reduce the priority of those
stars. However, this RV information remains useful for studying the stellar
multiplicity of nearby M~dwarfs. To search for companions around such
``deprioritized" M~dwarfs, we observed 14 IRD-SSP targets using Keck/NIRC2
observations with pyramid wavefront sensing at NIR wavelengths, leading to high
sensitivity to substellar-mass companions within a few arcseconds. We detected
two new companions (LSPM~J1002+1459~B and LSPM~J2204+1505~B) and two new
candidates that are likely companions (LSPM~J0825+6902~B and LSPM~J1645+0444~B)
as well as one known companion. Including two known companions resolved by the
IRD fiber injection module camera, we detected seven (four new) companions at
projected separations between ~au in total. A comparison of the
colors with the spectral library suggests that LSPM~J2204+1505~B and
LSPM~J0825+6902~B are located at the boundary between late-M and early-L
spectral types. Our deep high-contrast imaging for targets where no bright
companions were resolved did not reveal any additional companion candidates.
The NIRC2 detection limits could constrain potential substellar-mass companions
() at 10~au or further. The failure with Keck/NIRC2
around the IRD-SSP stars having significant RV trends makes these objects
promising targets for further RV monitoring or deeper imaging with JWST to
search for smaller-mass companions below the NIRC2 detection limits.Comment: 16 pages, 8 figures, accepted for publication in A
教育的対話能力開発の臨床心理学的研究(1) ― 教育的対話シナリオの事例研究 ―
The aim of this study was to develop a training program based on the "educational dialogue" theory for teachers (Kotani 2000). To achieve this, concepts regarding the "basic factors for educational dialogue," "tri-dimentionalization of dialogue" and the key factors in the therapeutic alliance-forming model in Psychoanalytic Systems (PAS) Theory were operatively defined. Using the analytic framework for these definitions, dialogue scenarios written by school teachers who participated in training programs were qualitatively analyzed. The knowledge thus acquired was useful for the future development of the training program
A Functional SNP in BNC2 Is Associated with Adolescent Idiopathic Scoliosis
Adolescent idiopathic scoliosis (AIS) is the most common spinal deformity. We previously conducted a genome-wide association study (GWAS) and detected two loci associated with AIS. To identify additional loci, we extended our GWAS by increasing the number of cohorts (2,109 affected subjects and 11,140 control subjects in total) and conducting a whole-genome imputation. Through the extended GWAS and replication studies using independent Japanese and Chinese populations, we identified a susceptibility locus on chromosome 9p22.2 (p = 2.46 × 10−13; odds ratio = 1.21). The most significantly associated SNPs were in intron 3 of BNC2, which encodes a zinc finger transcription factor, basonuclin-2. Expression quantitative trait loci data suggested that the associated SNPs have the potential to regulate the BNC2 transcriptional activity and that the susceptibility alleles increase BNC2 expression. We identified a functional SNP, rs10738445 in BNC2, whose susceptibility allele showed both higher binding to a transcription factor, YY1 (yin and yang 1), and higher BNC2 enhancer activity than the non-susceptibility allele. BNC2 overexpression produced body curvature in developing zebrafish in a gene-dosage-dependent manner. Our results suggest that increased BNC2 expression is implicated in the etiology of AIS
The mass determination of TOI-519 b: a close-in giant planet transiting a metal-rich mid-M dwarf
We report the mass determination of TOI-519 b, a transiting substellar object
around a mid-M dwarf. We carried out radial velocity measurements using Subaru
/ InfraRed Doppler (IRD), revealing that TOI-519 b is a planet with a mass of
. We also find that the host star is metal
rich ( dex) and has the lowest effective
temperature ( K) among all stars hosting known
close-in giant planets based on the IRD spectra and mid-resolution infrared
spectra obtained with NASA Infrared Telescope Facility / SpeX. The core mass of
TOI-519 b inferred from a thermal evolution model ranges from to
, which can be explained by both the core accretion and disk
instability models as the formation origins of this planet. However, TOI-519 is
in line with the emerging trend that M dwarfs with close-in giant planets tend
to have high metallicity, which may indicate that they formed in the core
accretion model. The system is also consistent with the potential trend that
close-in giant planets around M dwarfs tend to be less massive than those
around FGK dwarfs.Comment: 10 pages, 5 figures. Accepted for publication in PAS
An M dwarf accompanied by a close-in giant orbiter with SPECULOOS
In the last decade, a dozen close-in giant planets have been discovered
orbiting stars with spectral types ranging from M0 to M4, a mystery since known
formation pathways do not predict the existence of such systems. Here, we
confirm TOI-4860 b, a Jupiter-sized planet orbiting an M4.5 host, a star at the
transition between fully and partially convective interiors. First identified
with TESS data, we validate the transiting companion's planetary nature through
multicolour photometry from the TRAPPIST-South/North, SPECULOOS, and MuSCAT3
facilities. Our analysis yields a radius of for
the planet, a mass of for the star, and an orbital period of
1.52 d. Using the newly commissioned SPIRIT InGaAs camera at the
SPECULOOS-South Observatory, we collect infrared photometry in zYJ that spans
the time of secondary eclipse. These observations do not detect a secondary
eclipse, placing an upper limit on the brightness of the companion. The
planetary nature of the companion is further confirmed through high-resolution
spectroscopy obtained with the IRD spectrograph at Subaru Telescope, from which
we measure a mass of . Based on its overall
density, TOI-4860 b appears to be rich in heavy elements, like its host star.Comment: Accepted for publication in MNRAS Letter
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