Long-Lasting Effect of Infant Rats Endotoxemia on Heat Shock Protein 60 in the Pancreatic Acinar Cells: Involvement of Toll-Like Receptor 4

Introduction. Lipopolysaccharide endotoxin (LPS) is responsible for septic shock and multiorgan failure, but pretreatment of rats with low doses of LPS reduced pancreatic acute damage. Aim. We investigated the effects of the endotoxemia induced in the early period of life on Toll-like receptor 4 (TLR4), heat shock protein 60 (HSP60) and proapoptotic Bax, caspase-9 and -3 or antiapoptotic Bcl-2 protein expression in the pancreatic acinar cells of adult animals. Material and Methods. Newborn rats (25 g) were injected with endotoxin (Escherichia coli) for 5 consecutive days. Two months later, pancreatic acinar cells were isolated from all groups of animals and subjected to caerulein stimulation (10−8 M). Protein expression was assessed employing Western blot. For detection of apoptosis we have employed DNA fragmentation ladder assay. Results. Preconditioning of newborn rats with LPS increased TLR4, Caspase-9 and -3 levels, but failed to affect basal expression of HSP60, Bax, and Bcl-2. Subsequent caerulein stimulation increased TLR4, Bcl-2, and caspases, but diminished HSP60 and Bax proteins in pancreatic acinar cells. Endotoxemia dose-dependently increased TLR4, Bax, HSP60, and both caspases protein signals in the pancreatic acini, further inhibiting antiapoptotic Bcl-2. Conclusions. Endotoxemia promoted the induction of HSP60 via TLR4 in the infant rats and participated in the LPS-dependent pancreatic tissue protection against acute damage

Le rayonnement de Strasbourg en Pologne à l'époque de l'Humanisme

Kot Stanisław. Le rayonnement de Strasbourg en Pologne à l'époque de l'Humanisme. In: Revue des études slaves, tome 27, 1951. Mélanges André Mazon. pp. 184-200

EQUIVALENCE SCALE EXACTNESS AND STOCHASTIC INDIFFERENCE

W pracy dowodzimy twierdzenia, które wiąże założenie dokładności skal ekwiwalentności (ESE) z symetrycznym czynnikiem dominacji stochastycznej pierwszego rzędu. Dokładniej, niech X i Y będą rozkładami wydatków, odpowiednio, analizowanej grupy gospodarstw domowych i grupy gospodarstw odniesienia. Niech Z oznacza rozkład X skorygowany za pomocą pewnej skali ekwiwalentności. Jeśli spełnione jest założenie ESE, to Z jest stochastycznie indyferentne z X. Jednakże indyferencja stochastyczna (SI) nie implikuje ESE. Oznacza to, że SI jest założeniem słabszym niż ESE. Proponujemy obliczać skale ekwiwalentności na podstawie kryterium SI, gdy ESE nie jest spełnione.In this paper we prove the theorem, which links the equivalence scale exactness (ESE) assumption with the symmetric factor of the first order stochastic dominance. Namely, let X and Y be the expenditure distributions of an analysed group of households and the reference household group, respectively. Let Z be the X distribution adjusted by an equivalence scale. If the ESE assumption holds then Z will be the first order stochastically indifferent with Y. However, stochastic indifference (SI) does not imply ESE. This means that SI is a weaker assumption than ESE. We propose to calculate equivalence scales based on SI criterion when ESE is violated

Equivalence scales for continuous distributions of expenditure

Research background: In the actual sizable populations of households, the standard microeconomic concept of equivalence scales is intractable since its necessary condition of equality of household welfare levels is unlikely to be fulfilled. Purpose of the article: This paper aims to develop a concept of an equivalence scale, which can be suitable for continuous distributions of expenditures in the population. Methods: Using household welfare intervals, we get the random equivalence scale (RES) as the ratio of expenditure distributions of the compared populations of households. Findings & value added: We derive the parametric distribution of RES for the lognormal distributions of expenditures. The truncated distribution of RES is applied to account for possible economies of scale in the household size. A society?s inequality aversion can be helpful when selecting a single equivalence scale. We estimate RES for Poland using microdata on expenditures and subjective assessments of household welfare intervals. The estimated equivalence scales turned out to be very flat and dependent on welfare

STOCHASTIC EQUIVALENCE SCALES IN LOG-NORMAL DISTRIBUTIONS OF EXPENDITURES

In the paper, the properties of the stochastic equivalence scales (SES) are analysed when expenditure distributions are log-normal. The SES provides the equivalent distribution of expenditures when the population of households is heterogeneous with respect to such attributes as household size, demographic composition, etc. For log-normal expenditure distributions, the non-parametric SES deflators are proportional to the ration of geometric means in compared distributions. The statistical analysis of expenditure distributions for Poland in the years 2005-2010 shows that these deflators perform quite well

Wychowanie nowoczesne (od połowy w. XVIII do współczesnej doby)

wydanie drugie, zmienione i pomnożone