Society and the state in the pandemic context

Based on the importance of an unprecedented new reality, the authors were tasked with studying and analyzing the problems of interaction between the State and society in the context of the pandemic and the introduction of state measures to prevent the spread of viral infection, which to a degree or another limit the rights and freedoms of a person and citize

Forest legislation of Peter the great: traditions and innovations

Summing up the overall result of Peter's activities in the field of forest legislation and forest protection, we quote the words of V.V. Chernykh: "Despite the complexity and inconsistency of regulatory legal acts, Peter's law-making played an important role in the development of forest protection legislation. Some of them were included in the Forest Charter of the Empire, adopted in 1802, and in other regulatory legal documents that operated on the territory of the Russian state

The state and environmental management: general regulatory issues

The authors set the task based on the importance of the role of the state- to analyze the state policy of Russia and several foreign countries in the direction of environmental management. The research focus concerned the classification of the main policy areas of environmental management regulation and the identification of problems related to special state activities in this are

Burnout syndrome among doctors

This article presents a systematic review from 2009-2020 оn the topic of professional burnout among doctorsВ данной работе представлены результаты систематического обзора научных работ отечественных и зарубежных авторов, опубликованных в период с 2009-2020 гг. на тему профессионального выгорания среди враче

Concept of use of comprehensive fertilizers of long-term action on the basis of waste processing of potassium-magnesium ore as a new paradigm in improving soil fertility

Technology for the production and use of new multiple slow-release fertilizers from clay-salt waste (sludge) remaining as a result of potassium fertilizers production from natural K-Mg ores, is elaborated in Perm Federal Research Center. The main processes in the technology are waste enrichment and subsequent high-temperature calcination of the enriched concentrate. As a result, the product, received the name the calcine of clay-salt sludge, was formed having the properties of multiple slow-release fertilizer and ameliorant. Laboratory and field experiments on the calcine use as a potassium fertilizer were fulfilled. The studied crops were spring wheat, barley, and potato. The experimental scheme included such treatments: control (without fertilizers), NP – background; NP + KCl and NP + calcine. The use of calcine for grain crops (wheat, barley) on the NP background promoted the yield gains by 1.7–1.9 t/ha compared with the control, the use of standard NPK fertilizers – by 1.8–2.0 t/ha, the difference was within the error of the experiment (HCP05 = 0.21; 0.38 t/ha). The content of nitrogen, phosphorus and potassium in the grain and straw of both crops in the treatments using calcine was approximately equal to the variants using standard fertilizer and significantly higher compared to the control. Differences between calcine treatments were not significant. The application of N90P90 and full mineral fertilizer (N90P90K90) contributed to the yield increase of potato tubers by 1.43–4.51 t/ha respectively. The use of unconventional potassium fertilizer – calcine on the background of NP was not inferior in efficiency to the use of traditional fertilizer – potassium chloride. The quality parameters of the potato crop (dry matter and starch content in tubers, the content of heavy metals) were also not inferior compared to the use of traditional potassium fertilizer. The use of calcine for potato and cereals in rates equal to K60-120 did not lead to deterioration of the fertility indicators of sod-podzolic soil. Upon receipt of the cinder, one can use the additional unlimited set of components. In other words, this is a conceptual model for creating new types of mineral fertilizers with desired properties for different soil and climatic conditions and crops with different requirements for mineral nutrition

Modern microwave methods in solid state inorganic materials chemistry: from fundamentals to manufacturing

No abstract available

Possibilities of clinical use of designs based on zirconium dioxide, andevaluation of the main features of the new ceramic dental appointment

Every year, steadily increasing the quantity of patients, ortopedic treatment which is performed using structures made of zirconium dioxide. The interest of dentists to this method of replacing teeth and defects of dentition due to the fact that orthopedic constructions made of zirconium dioxide with the use of CAD I CAM technologies have high durability, aesthetics and precision. A method for the synthesis of nanocrystalline powder of Zr02, stabilizet with Y203, by co-deposition with the use of elements of the solgel technology for low temperature sintering. X-ray diffraction, thermal desorption of nitrogen, and electron microscopy study of powder characteristics, depending on synthesis conditions. Preclinical trials indicate the developed material meets the require ments of durability end aesthetics.С каждым годом, неуклонно увеличивается число пациентов, ортопедическое лечение которых проводится с использованием конструкций выполненных из диоксида циркония. Интерес стоматологов к данному методу замещения дефектов зубов и зубных рядов обусловлен тем, что ортопедические конструкции, изготовленные из диоксида циркония с применением CAD/CAM технологий обладают высокой прочностью, эстетичностью и прецензионностью. Разработана методика синтеза нанокристаллического порошка Zr02, стабилизированного Y203, методом совместного осаждения с применением элементов золь-гель технологии, для низкотемпературного спекания. Методами рентгеновской дифракции, тепловой десорбции азота и электронной микроскопии изучены характеристики порошка в зависимости от условий синтеза. Проведенные доклинические испытания свидетельствуют, что разработанный материал отвечает требованиям прочности и эстетичности

Difficulties of radiological diagnosis оf small breast cancers

Introduction. Breast cancer in the structure of malignancies in women takes the 1st place. There has been an annual increase in morbidity, including due to improvements in diagnostic interventions and screening. Mammography and ultrasound of the breasts is mandatory when diagnosing breast cancer. The difficulties of diagnosis are revealed in small tumorsВведение. Рак молочной железы (РМЖ) в структуре злокачественных новообразований (ЗНО) у женщин занимает первое место. Отмечается ежегодный прирост заболеваемости, в том числе из-за усовершенствования диагностических мероприятий и скрининга. Маммография и ультразвуковое исследование молочных желез является обязательным при постановке диагноза РМЖ. Сложности диагностики выявляются при опухолях малых размеров

Two Novel Amyloid Proteins, RopA and RopB, from the Root Nodule Bacterium Rhizobium leguminosarum

Amyloids represent protein fibrils with a highly ordered spatial structure, which not only cause dozens of incurable human and animal diseases but also play vital biological roles in Archaea, Bacteria, and Eukarya. Despite the fact that association of bacterial amyloids with microbial pathogenesis and infectious diseases is well known, there is a lack of information concerning the amyloids of symbiotic bacteria. In this study, using the previously developed proteomic method for screening and identification of amyloids (PSIA), we identified amyloidogenic proteins in the proteome of the root nodule bacterium Rhizobium leguminosarum. Among 54 proteins identified, we selected two proteins, RopA and RopB, which are predicted to have β-barrel structure and are likely to be involved in the control of plant-microbial symbiosis. We demonstrated that the full-length RopA and RopB form bona fide amyloid fibrils in vitro. In particular, these fibrils are β-sheet-rich, bind Thioflavin T (ThT), exhibit green birefringence upon staining with Congo Red (CR), and resist treatment with ionic detergents and proteases. The heterologously expressed RopA and RopB intracellularly aggregate in yeast and assemble into amyloid fibrils at the surface of Escherichia coli. The capsules of the R. leguminosarum cells bind CR, exhibit green birefringence, and contain fibrils of RopA and RopB in vivo.This work was supported by the Russian Science Foundation, grant 17-16-01100

Clinical case of Jeune syndrome

The paper reports a clinical case of Jeune syndrome in a baby, in whom the diagnosis was established immediately after his birth. He was also diagnosed as having multiple  congenital malformations, such as Dandy–Walker anomaly, hexadactyly of the left hand, cleft palate, choroidal colobomas in both eyes, and atrial septal defect and he also had interstitial nephritis and hepatitis