Omineca Herald, May, 23, 1924

Background: LKB1 mutations are the underlying genetic abnormality causing Peutz-Jeghers syndrome (PJS) and are a potential target for everolimus. In this phase II study, the efficacy of everolimus on polyp and tumor growth in PJS patients was investigated. Methods: Adult patients with a proven LKB1 mutation and who were suitable for everolimus treatment were included in two different PJS cohorts: (a) patients with unresectable malignancies and (b) patients with high-risk polyps. Treatment in both groups was oral everolimus, 10 mg daily. Response rates were primary endpoints for both cohorts. Results: Between October 2011 and April 2016, only two patients were enrolled, one in each cohort. A 49-year-old patient with advanced pancreatic cancer in cohort 1 was progressive after 2 months. A 52-year-old male patient in cohort 2 experienced severe toxicity and refused treatment after 4 months, even though endoscopy suggested stabilization of polyps. Adverse

Toonbeelden: gedachten over provinciaal omgevingsrecht ter herinnering aan Toon de Gier

Dit boek is een eerbetoon aan mr. Toon de Gier, die op 15 januari 2013 onverwachts overleed. Toon was hoofddocent Staats- en bestuursrecht aan de Universiteit Utrecht. Zijn wetenschappelijke interesse ging met name uit naar het ruimtelijk bestuursrecht en het omgevingsrecht, waarvan de talloze publicaties van zijn hand over deze onderwerpen blijk geven. Met deze publicaties heeft Toon niet alleen een belangrijke bijdrage geleverd aan de ontwikkeling van het omgevingsrecht, het wetenschappelijke debat en het onderwijs, maar heeft hij ook de rechtspraktijk een grote dienst bewezen. De auteurs behandelen in deze bundel een keur aan actuele, deels geheel nieuwe, onderwerpen rond het thema provinciaal omgevingsrecht. Mede in de stijl van Toon de Gier worden nieuwe ideeën en inzichten aangedragen en wordt op wetgeving en rechtspraak, waar nodig, kritiek uitgeoefend

Rechtsvergleichende Studie zu Instrumenten eines nachhaltigen Landmanagements Comparative Law Analysis on Instruments for Sustainable Land Management (CLAIM)

This study provides a comparative legal analysis of how key governance requirements of sus-tainable land use development are accounted for by the environmental and planning law re-gimes of six selected countries (Germany, The Netherlands, Poland, Switzerland, Spain, USA). To that end, a set of key governance requirements for sustainable land use development were ex-tracted from the available sustainability discourcse as comparative criteria, and on that basis, an extensive questionnaire was developed and answered by national experts. The applied governance critiera includes regulatory provision of (1) a transparent sustainability concept and translation into concrete environmental quality objectives (2) a coordinated and integrated approach of land use management, (3) the constant generation and incorporation of to new sustainability knowledge and adaption of land-use decisions to best available knowledge and lastly (4) effective participation of the public and stakeholders. With regard to these criteria, the study is analyzing both cross-sectoral and sector specific steering approaches. Spatial plan-ning is paid particular attention to as a most important cross-sectoral approach. The sectors analyzed include agriculture, river basin related water resource management, urban develop-ment and energy landscapes. The evaluation of the survey depicts how far the reported coun-tries have advanced in “sustaining” their environmental and planning law and how, yet, diverse opportunities for improvement remain. The comparative law analysis based on the mentioned governance criteria reveals a heteroge-neous picture requiring differentiated appraisal. In very coarse view, however, it can be summa-rized that most notable sustainability deficits of the relevant legal regimes relate to the determi-nation of clear environmental quality objectives and effective implementation instruments, while respectable advancements have been achieved in all analyzed legal orders with regard to integration, participation, generation of knowledge and adaptive design of land-use regulation schemes