Integrated quality assessment of drinking water

Nowadays, water quality issues continue to be an essential research in the field of hygiene and ecology. The authors carried out an integrated assessment of the drinking water from water supply systems in Selyatino settlement, the Naro-Fominsk district of the Moscow region, in terms of chemical harmlessness indicators. It was revealed that there are elevated levels of health risk at peroral intake of drinking water from all the wells at the settlemen

Ecological safety of building materials, in the production of which production and consumption waste are used (by the example of eco-concrete)

The problem of recycling of solid municipal and construction waste remains relevant over the world to this day. One of the possible solutions to this problem is the use of waste as the secondary raw materials for the production of raw materials. The ecological safety of a sample of eco concrete was carried out, when for manufacturing of which was used as the aggregate shredded waste. When analyzing exhalation of organic component from a sample of concrete lock, an increased content of ammonia was detected, and the risk for the human health was calculated. The use of this resource saving technology can be considered promising if the concrete matrix is improved

Ecological safety of building materials, in the production of which production and consumption waste are used (by the example of eco-concrete)

The problem of recycling of solid municipal and construction waste remains relevant over the world to this day. One of the possible solutions to this problem is the use of waste as the secondary raw materials for the production of raw materials. The ecological safety of a sample of eco concrete was carried out, when for manufacturing of which was used as the aggregate shredded waste. When analyzing exhalation of organic component from a sample of concrete lock, an increased content of ammonia was detected, and the risk for the human health was calculated. The use of this resource saving technology can be considered promising if the concrete matrix is improved

BCL2-regulated apoptotic process in myocardial ischemia-reperfusion injury (Review)

The leading cause of death in developed countries is cardiovascular disease, where coronary heart disease is the main cause of death. Myocardial reperfusion is the most significant method to prevent cell death after ischemia. However, restoration of blood flow may paradoxically lead to myocardial ischemia-reperfusion injury (MI/RI) accompanied by metabolic disturbances and cardiomyocyte death. As the myocardium has an extremely limited ability to regenerate, the mechanisms of regulated cell death, including apoptosis, are the most significant for contemporary research due to their reversibility. BCL2 is a key anti-apoptotic protein. There are several signaling pathways and compounds regulating BCL2, including PI3K/AKT and MEK1/ERK1/2, JAK2/STAT3, endothelial nitric oxide synthase, PTEN, cardiac ankyrin repeat protein and microRNA, which can serve as targets for modern methods of cardioprotective therapy inhibiting intrinsic apoptosis and saving viable cardiomyocytes after MI/RI. The present review considers the mechanisms of Bcl2-regulated apoptosis in the development and treatment of MI/RI. © This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License

Выработка мелатонина при эссенциальной гипертензии по общепринятым и модифицированным световым графикам

Установлено, что дневная концентрация 6-СМТ в моче была достоверно ниже по сравнению с ночными значениями у гипертензивных крыс, подвергавшихся воздействию как 12:12, так и 16:8 светотеневых графиков. Дневная концентрация 6-СМТ составила 25,5 ± 1,49 нг/мл у нормотензивных крыс линии Wistar и была достоверно снижена до 16,27 ± 1,23 и 14,55 ± 1,32 нг / мл у крыс линии SHR, находящихся под 12:12 и 16:8 светотеневым графиком соответственно. Также наблюдалось увеличение разницы между дневным и ночным 6-СОМТ у гипертензивных крыс, содержавшихся в обоих светотеневых режимах по сравнению с контролем. Между тем никакой разницы в содержании мочи 6-SMT дневного времени не было увидено под светлым режимом 12:12 по сравнению с 16:8 между 2 группами в составе крысы SHR. Что касается ночного времени, то значения 6-СМТ мочи у крыс линии Wistar, крыс линии SHR в режимах 12:12 и 16:8 свет-темно были следующими: 32,74 ± 2,78, 30,37 ± 2,54 и 26,08 ± 2,35 нг/мл без достоверных различий между группами животных