Estimation of changes in spermogram and index of sperm DNA fragmentation in patients with premature ejaculation receiving Neurodoz biocomplex

Background. An incidence of premature ejaculation (PE) in men of reproductive age of 24–45 years is 23 %. The treatment of PE is based on antidepressants from the group of selective serotonin re-uptake inhibitors. However, drugs of this group have gametotoxic action.Objective. Evaluate the effectiveness of Neurodoz biocomplex, its effect on the parameters of spermogram and sperm DNA integrity in patients with PE.Materials and methods. The study involved 16 patients with PE and normozoospermia aged from 26 to 35 years. Ejaculate and sperm DNA fragmentation were assessed by Halosperm (Halotech®) method before and after the therapy. Duration of treatment was 2 months. Evaluation of efficacy was based on the duration of sexual intercourse, as well as on the visual analogue scale and the questionnaire data of patients with premature ejaculation.Results. In 8 weeks there was a decrease in ejaculate volume from to 3.6 ± 1.1 down to 3.2 ± 1.1 mL (p = 0.312) and an increase in the concentration of sperm (34.2 ± 9.8) × 106 up to (35.6 ± 9.7) × 106 (p = 0.688). Sperm motility (category a + b) increased from 36.6 ± 4.3 to 37.2 ± 4.5 % (p = 0.703), the percentage of morphologically normal forms increased from 14.6 ± 1.4 up to 14.8 ± 1.1 (p = 0.656). DNA fragmentation of sperm has decreased from 15.6 ± 2.7 down to 15.4 ± 2.7 % (p = 0.635). Duration of intravaginal latency increased from 101.8 ± 34.4 (45–150) up to 217.3 ± 28.9 (190–280) sec (p < 0.001). An overall score according to the premature ejaculation questionnaire decreased from 13.9 ± 3.0 (9–20) down to 4.4 ± 1.9 (0–7) (p < 0.001). Visual analogue scale symptoms improved from 7.3 ± 1.7 (5–10) to 2.6 ± 1.2 (0–4) (p < 0.001).Conclusion. Neurodoz is an effective and safe agent for PE correction. Giving an absence of negative impact of biocomplex on spermatogenesis in patients with normozoospermia, it is possible to administer it to men who are trying to conceive. Further study is necessary in order to assess an impact of the drug on semen parameters in subfertile patient

Occasional Combinatorial Lexicology as an Area of Study of Occasional Collocations

The article is devoted to occasional combinatorial lexicology as a separate area of combinatorial linguistics, more precisely, to lexicology studying occasional collocations, or atypical, individually authored and non-reproducible word combinations created through deliberate violation of lexico-semantic compatibility for performing certain functionally expressive tasks within a specific text. Particular attention is paid to the fact that the authors create and include occasional collocations for various purposes: first, to express an unconventional attitude to the object or subject described, secondly, to give it its own characteristic, thirdly, to put a certain emphasis on any part of the narration, etc. The technique of the functional-semantic analysis of occasional collocations as the basic, complex method of investigation is presented in the article, and features of this type of collocations are revealed. The authors believe that the allocation of occasional combinatorial lexicology contributes to the development and improvement of combinatorial science and the lexicological branch, provides scientifically substantiated interpretation and description of special lexical units - occasional collocations

New personalized genetic mouse model of Lesch-Nyhan syndrome for pharmacology and gene therapy

In the current study, we present the results of the generation of a genetically modified mouse strain carrying a deletion in the HPRT1 gene. These mice can be effectively used for the preclinical testing of new drugs aimed at the treatment of Lesch-Nyhan syndrom

DIAGNOSTICS OF POLYCULTURAL COMPETENCE OF FUTURE TEACHERS

Introduction. Nowadays, repeatedly increasing migration flows connected with labor international migration and cocurrent frequent ethnic conflicts directly touched upon the education as intolerance to representatives of other cultures is most considerably shown among youth. Taking into account those processes, the problem of teachers’ training capable to cope with their professional duties in the conditions of ethnic and religious variety is brought into focus. Polycultural competence of the professional standard of the teacher is counted as a basic one. At the same time, the components of polycultural education are insufficiently fully and accurately registered in obligatory results of development of the main programs of pedagogical specialties. The aim of the present publication is to discuss the need of subject content changes of teachers’ vocational training at Federal University taking into account the specifics of the multinational regional environment and justification of expediency of regular diagnostics development of polycultural competence among future teachers for dynamics tracking of the planned personal new growths and their timely correction. Methodology and research methods. The research is based on cross-cultural, theoretical and activity-based studies as the most relevant ones for the present stage of professional and pedagogical training. Theoretical and empirical methods of studying of formation of components of poly-cultural competence of students are used; interviewing and questioning of students, methods of quantitative-qualitative and content analysis are applied. Results and scientific novelty. The experience of complex diagnostics of level of polycultural competence of students of pedagogical specialties of the Siberian Federal University is presented (Krasnoyarsk). The analysis of monitoring results served as basis for creation of the model of components formation of this competence which is obligatory for a teacher carrying out the professional activity in the multinational and multireligious environment. The mechanisms of the organization of development of poly-cultural competence are described at the target, substantial, personal, strategic, organizational and technological levels.Practical significance. The research materials will be useful for educators to improve the quality of teacher training in terms of multicultural competence formation; school teachers working in multinational classes with migrant children whose training requires not only knowledge of the subject, but also the ways of socialization judging from national or religious specifics. Введение. Многократно увеличившиеся в последнее время миграционные потоки, связанные в том числе с трудовой международной миграцией, и сопутствующие им участившиеся конфликты на национальной почве непосредственно коснулись сферы образования, так как нетерпимость к представителям других культур наиболее радикально проявляется прежде всего среди молодежи. На фоне этих процессов актуализируется проблема подготовки педагогов, способных справляться со своими профессиональными обязанностями в условиях этнического и религиозного многообразия. Поликультурная компетентность в профессиональном стандарте педагога причисляется к числу базовых. Вместе с тем в обязательных результатах освоения основных программ педагогических специальностей компоненты поликультурного образования прописаны недостаточно полно и четко. Цель публикации – обсуждение необходимости изменения предметного содержания профессиональной подготовки учителей в федеральном университете с учетом специфики многонациональной региональной среды и обоснование целесообразности регулярной диагностики развития поликультурной компетентности у будущих педагогов для отслеживания динамики запланированных личностных новообразований и своевременной их коррекции. Методология и методы. Методологической базой исследования явились межкультурный, системный и деятельностный подходы как наиболее релевантные, с точки зрения авторов, для современного этапа профессионально-педагогической подготовки. Использовались теоретические и эмпирические методы изучения сформированности компонентов поликультурной компетентности студентов; применялись интервьюирование и анкетирование учащихся, методики количественно-качественного и контент-анализа. Результаты и научная новизна. Представлен опыт комплексной диагностики уровня поликультурной компетентности студентов педагогических специальностей Сибирского федерального университета (Красноярск). Анализ результатов мониторинга послужил базой для создания модели формирования компонентов данной компетентности, обязательной для педагога, осуществляющего свою профессиональную деятельность в многонациональной и многоконфессиональной среде. Описаны механизмы организации процесса развития поликультурной компетентности на целевом, содержательном, личностном, стратегическом, организационном и технологическом уровнях. Практическая значимость. Материалы исследования будут полезны работникам образования для повышения качества подготовки педагогов в части формирования поликультурной компетентности; учителям школ, работающим в многонациональных классах с детьми-мигрантами, обучение которых требует не только знания предмета, но и способов социализации школьников исходя из их национальных особенностей.The research was carried out with the support of the Russian Humanitarian Scientific Foundation № 16-16-24005 «Development of scientific-educational complex of Krasnoyarsk region by means of electronic continuous education platform (PL2S)».Работа выполнена в рамках проекта РГНФ № 16-16-24005 «Развитие научно-образовательного комплекса Красноярского края средствами электронной платформы непрерывного образования (PL2S)»

Neyrodoz in the treatment of secondary premature ejaculation in patients with chronic prostatitis

Premature ejaculation (PE) is the type of sexual dysfunction, which is characterized by constant or nearly constant uncontrolled ejaculation before vaginal penentration or within minutes of the start of sexual intercourse, that causing a feeling of sexual dissatisfaction and leading to sexual frustration among the partners. It has been shown that the antimicrobial and antiinflammatory therapy of chronic prostatitis (CP) increases the duration of sexual intercourse and improves the control over the ejaculation. PE in the patients with CP may be an independent sexual disorder that may require a specific correction. Antidepressants are the first line of drugs in the treatment of PE according to the recommendations of the European Association of Urology. However, some patients refuse to intake this medicine. The aim of our study was to evaluate the clinical efficacy and safety of Neyrodoz in the treatment of PE in patients with CP.Materials and methods. The study included 32 patients (mean age 37.5 years) who have had complains on PE after the treatment of CP. All the patients were randomly selected into two groups. 1st – basic group (n = 15) and 2nd – control group (n = 17).The first group patients intook Neyrodoz 2 capsules twice a day. The second group got placebo in the same dose during 30 days.Results. The time of intravaginal latency increased from 40,8 ± 9,9 (25–56) to180,1± 41,2 (120–240) seconds in patients of the 1st group after the therapy. The score of tool-PEDT decreased from 15,8 ± 3,1 (11–20) to 3,9 ± 2,9 (0–8). The visual analogue scale (VAS) symptoms improved from 8,6 ± 1,4 (6–10) to 2,5 ± 2,1 (0–5). The time of intravaginal latency increased from 38,4 ± 10,0 (25–59) to 40,7 ± 7,4 (35–59) seconds in 14 of 17 men in the second group of patients. The score of tool-PEDT decreased from 15,6 ± 2,8 (11–20) to 14,3 ± 2,7 (12–19). The VAS symptoms improved from 8,9 ± 1,3 (6–10) to 8,5 ± 1,7 (6–10).Conclusions. Neyrodoz is an effective and safe medicine to the correction of PE in patients with CP, who did not get an effect after the treatment of CP

Selective serotonin reuptake inhibitors and spermatogenesis

Introduction. According to the WHO data, depression is a common disease among women and men of reproductive age. One line of the correction of depressive disorders is selective serotonin reuptake inhibitors (SSRIs). The ingestions have shown that using SSRIs harms sperm quality. The literature date of evaluation of male fertility after discontinuation of antidepressants is quite limited.Purpose of the study. To evaluate the influence of Fluoxetine intake on semen parameters, sperm DNA fragmentation and hormonal status.Materials and methods. Twenty-five men (mean age - 35.2 ± 4.5 yo) with depression were included in the study. Fluoxetine (20 mg per day) was prescribed to all the patients for 12 wk. Semen parameters, sperm DNA fragmentation, sex hormones levels were measured before-after treatment and 3 mo behind discontinuation.Results. After 12 weeks of the treatment the mean semen volume decreased from 3.1 ± 0.7 to 2.9 ± 0.7 ml (p = 0.638), sperm concentration - from 39.4 ± 18.5 to 34.3 ± 16.8 mln/ml (p = 0.384), sperm motility decreased from 41.7 ± 7.6 to 35.5 ± 7.8% (p < 0.05), the mean percent of normal morphology form - from с 12.7 ± 2.8 to 10.7 ± 2.2% (p < 0.001). Sperm DNA fragmentation increased 16.2 ± 4.9 to 22.2 ± 4.3% (p < 0.001). The mean semen volume, sperm concentration, motility, percentage of normal morphology increased and reverted to the normal levels after 3 mounts of drug discontinuation. Sperm DNA fragmentation index decreased, and it had the values less than before the treatment that positively correlated with the reduction of depression's symptoms. It was not significant dynamics in hormonal parameters before and after the therapy.Conclusion. Using fluoxetine has a reversible negative effect on male fertility. It is important to inform the patients about the temporary side effects of SSRIs in fatherhood planning cases

Cardiac arrhythmias in patients with bronchial asthma

Introduction. According to modern data, bronchial asthma (BA) is an independent risk factor for the development of cardiac arrhythmias (CA), and the use of long-acting β2-agonists (LABA) in basic therapy may further increase the risks of CA.Aim. To study the structure and risk factors of cardiac arrhythmias in patients with bronchial asthma. Materials and methods. A retrospective study included 181 patients aged 69.4 ± 0.8 years, hospitalized for asthma, with the presence a CA in medical documentation.Results. Among BA patients with CA, supraventricular CA were found in 71.3% (129) patients, ventricular CA in 16.6% (30), combined CA in 12.2% (22). In 52.5% (95) patients, supraventricular extrasystole was detected, in 35.9% (65) – atrial fibrillation, in 28.7% (52) – ventricular extrasystole, in 1.1% (2) – paroxysmal supraventricular tachycardia, in 0.6% (1) – paroxysmal ventricular tachycardia. It was found that supraventricular CA was significantly more frequent among women (χ2 = 5.974, p = 0.05). The severity of BA and the level of control are not related to the type of observed CA (χ2 = 0.755, p = 0.685 and χ2 = 3.003, p = 0.557, respectively).Discussion. The use of a combination of ICS and LABA in basic BA therapy versus the use of ICS alone does not have a significant effect on the frequency and structure of cardiac arrhythmias (χ2 = 1.172, p = 0.556).Conclusion. In hospitalized BA patients, supraventricular cardiac arrhythmias are most often detected, among which supraventricular extrasystole and atrial fibrillation take the main place