1 research outputs found
A dementia neuropathológiája Parkinson-syndromákban = Neuropathology of dementia in Parkinson's syndromes
Vizsgálatainkban Parkinson-syndromákban (multiszisztĂ©más atrophia, Parkinson-kĂłr, progresszĂv supranuclearis bĂ©nulás, vascularis parkinsonismus (Binswanger-betegsĂ©g) a dementia neuropatholĂłgiai hátterĂ©t objektĂv sejtszámlálási mĂłdszerekkel vizsgáltuk, az Ăgy kapott adatokat összehasonlĂtva az adott terĂĽlet neuropatholĂłgiai markereivel. A sejtszámlálást optikai disszektor segĂtsĂ©gĂ©vel vĂ©geztĂĽk, a neuropatholĂłgiai eltĂ©rĂ©seket immunhisztokĂ©miai mĂłdszerekkel határoztuk meg. MultiszisztĂ©más atrophiában a hippocampalis formatio patolĂłgiájának kĂĽlönbsĂ©gĂ©t igazoltuk demens Ă©s nem demens betegek között. A subcorticalis magvak sejtszámának kĂĽlönbsĂ©gĂ©t nem igazoltuk. Parkinson- kĂłrban Ă©s progresszĂv supranuclearis paresisben a statisztikai feldolgozáshoz szĂĽksĂ©ges számĂş minta összegyűjtĂ©se mĂ©g folyamatban van. Vascularis Parkinson- syndromában kimutattuk a subcorticalis fehĂ©rállományi Ă©s a corticalis NFT patolĂłgia kapcsolatát. Ăšgy találtuk, hogy a territoriális nagyĂ©rbetegsĂ©gben az oligodendroglia károsodása kisebb mĂ©rtĂ©kű, mint kisĂ©rbetegsĂ©gben. | Using objective stereological cell-counting methods, we studied the neuropathological basis of dementia in Parkinsonian syndromes (multiple system atrophy, Parkinson)s disease, progressivw supranuclear palsy and vascular parkinsonism (Binswanger's disease)) and compared the data with the neuropathological markers of the given area. Optical dissector was used for counting the cells while the neuropathological markers were identified by immunohistochemistry. Our results proved that the pathology of the hippocampal formations is different between the demented and non-demented patients with multiple system atrophy. The number of the neurones in the subcortical nuclei was similar. The number of the cases in Parkinson?s disease and in progressive supranuclear palsy is need to be increased The correlation of the cortical neurofibrillary pathology and the subcortical white matter pathology was proved in vascular Parkinsonian- syndrome. We found that the damage (tau pathology) of the oligodendroglial cells is less severe in territorial infarctions than in subcortical small vessel disease