Temperature profiling of ex-vivo organs during ferromagnetic nanoparticles-enhanced radiofrequency ablation by fiber Bragg grating arrays

In this paper, we present real-time profiles of temperature during a ferromagnetic nanoparticles (NPs)enhanced radiofrequency ablation (RFA). A minimally invasive RFA setup has been prepared and applied ex vivo on a liver phantom; NPs (with concentration of 5 mg/mL) have been synthetized and injected within the tissue prior to perform the ablation, in order to facilitate the heat distribution to the peripheral sides of the ablated tissue. Temperature detection has been realized in situ with a network of 15 fiber Bragg grating (FBG) sensors in order to highlight the impact of the NPs on the RFA mechanism. Obtained temperature profiles and thermal maps confirm that nanoparticles injection ensures better heat penetration than in case of pristine RFA procedure. The results show that adding NPs solution leads to extending the successfully ablated area achieving a double-sized lesion

Feedback-controlled laser ablation for cancer treatment: comparison of On-Off and PID control strategies

: Laser ablation is a rising technique used to induce a localized temperature increment for tumor ablation. The outcomes of the therapy depend on the tissue thermal history. Monitoring devices help to assess the tissue thermal response, and their combination with a control strategy can be used to promptly address unexpected temperature changes and thus reduce unwanted thermal effects. In this application, numerical simulations can drive the selection of the laser control settings (i.e., laser power and gain parameters) and allow evaluating the thermal effects of the control strategies. In this study, the influence of different control strategies (On-Off and PID-based controls) is quantified considering the treatment time and the thermal effect on the tissue. Finite element model-based simulations were implemented to model the laser-tissue interaction, the heat-transfer, and the consequent thermal damage in liver tissue with tumor. The laser power was modulated based on the temperature feedback provided within the tumor safety margin. Results show that the chosen control strategy does not have a major influence on the extent of thermal damage but on the treatment duration; the percentage of necrosis within the tumor domain is 100% with both strategies, while the treatment duration is 630 s and 786 s for On-Off and PID, respectively. The choice of the control strategy is a trade-off between treatment duration and unwanted temperature overshoot during closed-loop laser ablation. Clinical Relevance-This work establishes that different temperature-based control of the laser ablation procedure does not have a major influence on the extent of thermal damage but on the duration of treatment

Towards inline spatially resolved temperature sensing in thermal ablation with chirped fiber Bragg grating

We investigate the theory and feasibility of an in-line spatially resolved temperature sensor, suitable for thermal ablation monitoring. The sensor is based o a chirped fiber Bragg grating (CFBG). The CFBG is modelled as a chain of Bragg gratings, each sensitive to local temperature variations. By using a combination of iterative and statistical optimization techniques, it is possible to use demodulate the CFBG, in case of a Gaussian-like spatial temperature profile. A feasibility test based on CFBG simulation shows that the CFBG returns error <1 mm on cells damage threshold spatial estimation and good noise resilience

Simultaneous Distributed Sensing on Multiple MgO-Doped High Scattering Fibers by Means of Scattering-Level Multiplexing

International audienceWe introduce a novel multiplexing technique applied to optical fiber distributed sensors, based on optical backscatter re-flectometry (OBR) and high-scattering MgO-doped fibers. In this paper, we demonstrate the possibility of simultaneously detecting multiple fiber with a single scan using an OBR distributed sensor, and successfully discriminating each sensing region (with ∼1 mm spatial resolution). The sensing element is a high-scattering fiber with MgO-based nanoparticles doping in the core, that emits a scattering signal more than 40 dB larger than a standard fiber, while having similar temperature and strain sensitivity. Multiplex-ing occurs as the scattered light from a sensing fiber overshadows the amount of scattering occurring in all the other channels. The setup has been validated for temperature sensing and implemented in an epidural catheter with multiple fibers fixed to the outer walls for strain sensing. The proposed solution goes beyond the multi-plexing methods which exploit 1 × N switches, as the multiplexing is simultaneous and not rearranged in different time slots

Refractive Index Sensor by Interrogation of Etched MgO Nanoparticle-Doped Optical Fiber Signature

International audienc

Thermal profile detection through high-sensitivity fiber optic chirped Bragg grating on microstructured PMMA fiber

[EN] In this work, a linearly chirped fiber Bragg grating (CFBG) inscribed in a microstructured polymer optical fiber (mPOF) has been demonstrated for detecting temperature pro- files during thermal treatments. A CFBG of 10 mm length and 0.98 nm bandwidth has been inscribed in a mPOF fiber by means of a KrF laser and uniform phase mask. The CFBG has a high temperature sensitivity of -191.4 pm/°C). The CFBG has been used as a semi-distributed temperature sensor, capable of detecting the temperature profile along the grating length, for scenarios that account minimally invasive biomedical treatments. Two experiments have been designed to validate the CFBG tem- perature reconstruction, using a linear gradient, and a research- grade radiofrequency ablation (RFA) setup to apply Gaussian- shaped temperature spatial profiles. The result is that the higher sensitivity of the CFBG supports the detection of spatially non- uniform temperature fields by means of spectral reconstruction.This work was supported in part by Nazarbayev University, Research Council (ORAU project LIFESTART), in part by Fundacao para a Ciencia e Tecnologia (FCT)/MEC through National funds and when applicable co-funded by FEDER PT2020 partnership agreement under the project UID/EEA/50008/2013, and in part by the Research Excellence Award Programme GVA PROMETEO 2017/103 FUTURE MICROWAVE PHOTONIC TECHNOLOGIES AND APPLICATIONS. The work of C. Marques was supported by FCT through the fellowship SFRH/BPD/109458/2015.Korganbayev, S.; Min, R.; Jelbuldina, M.; Hu, X.; Caucheteur, C.; Bang, O.; Ortega Tamarit, B.... (2018). Thermal profile detection through high-sensitivity fiber optic chirped Bragg grating on microstructured PMMA fiber. Journal of Lightwave Technology. 36(20):4723-4729. https://doi.org/10.1109/JLT.2018.2864113S47234729362

Characterization of susceptibility artifacts in magnetic resonance thermometry images during laser interstitial thermal therapy: dimension analysis and temperature error estimation

Objective: Laser interstitial thermal therapy (LITT) is a minimally invasive procedure used to treat a lesion through light irradiation and consequent temperature increase. Magnetic Resonance Thermometry Imaging (MRTI) provides a multidimensional measurement of the temperature inside the target thus enabling accurate monitoring of the zone of damage during the procedure. In proton resonance frequency shift-based thermometry, artifacts in the images may strongly interfere with the estimated temperature maps. In our work, after noticing the formation of the dipolar-behavior artifact linkable to magnetic susceptibility changes during in vivo LITT, an investigation of susceptibility artifacts in tissue-mimicking phantoms was implemented. Approach: The artifact was characterized: (i) by measuring the area and total volume of error regions and their evolution during the treatment; and (ii) by comparison with temperature reference provided by three temperature sensing needles. Lastly, a strategy to avoid artifacts formation was devised by using the temperature-sensing needles to implement a temperature-controlled LITT. Main results: The artifact appearance was associated with gas bubble formation and with unwanted treatment effects producing magnetic susceptibility changes when 2 W laser power was set. The analysis of the artifact's dimension demonstrated that in the sagittal plane the dipolar-shape artifact may consistently spread following the temperature trend until reaching a volume 8 times bigger than the ablated one. Also, the artifact shape is quite symmetric with respect to the laser tip. An absolute temperature error showing a negative Gaussian profile in the area of susceptibility artifact with values up to 64.4 °C was estimated. Conversely, a maximum error of 2.8 °C is measured in the area not-affected by artifacts and far from the applicator tip. Finally, by regulating laser power, susceptibility artifacts formation was avoided, and appreciable thermal damage was induced. Significance: Such findings may help in improving the MRTI-based guidance of thermal therapies

Fiber Optic Refractive Index Distributed Multi-Sensors by Scattering-Level Multiplexing With MgO Nanoparticle-Doped Fibers

© 2020 IEEE. Personal use of this material is permitted. Permissíon from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertisíng or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.[EN] In this work, we present the architecture of a multiplexed refractive index (RI) sensing system based on the interrogation of Rayleigh backscattering. The RI sensors are fabricated by fiber wet-etching of a high-scattering MgO nanoparticle-doped fiber, without the need for a reflector or plasmonic element. Interrogation is performed by means of optical backscatter reflectometry(OBR), which allows a detection with a millimeter-level spatial resolution. Multiplexing consists of a simultaneous scan of multiple fibers, achieved by means of scattering-level multiplexing (SLMux) concept, which uses the backscattered power level in each location as a diversity element. The sensors fabricated have sensitivity in the order of 0.473-0.568 nm/RIU (in one sensing point) and have been simultaneously detected together with a distributed temperature sensing element for multi-parameter measurement. An experimental setup has been prepared to demonstrate the capability of each sensing region to operate without cross-talk, while operating multi-fiber detection.This work was supported in part by the ORAU Programme at Nazarbayev University (LIFESTART and FOSTHER Grants), in part by the Agence Nationale de la Recherche (ANR) Project NanoSlim under Grant ANR-17-17-CE08-0002, in part by the National Natural Science Foundation for Excellent Youth Foundation of China under Grant 61722505, in part by the Key Program of Guangdong Natural Science Foundation under Grant 2018B030311006, and in part by The Spanish Ministry of Economy and Competitiveness under Grant DIMENSION TEC2017 88029-R. The associate editor coordinating the review of this article and approving it for publication was Prof. Marco Petrovich.Ayupova, T.; Shaimerdenova, M.; Korganbayev, S.; Sypabekova, M.; Bekmurzayeva, A.; Blanc, W.; Sales Maicas, S.... (2020). Fiber Optic Refractive Index Distributed Multi-Sensors by Scattering-Level Multiplexing With MgO Nanoparticle-Doped Fibers. IEEE Sensors Journal. 20(5):2504-2510. https://doi.org/10.1109/JSEN.2019.2953231S2504251020

Largely tunable dispersion chirped polymer FBG

[EN] We demonstrate a largely tunable dispersion fiber Bragg grating (FBG) inscribed in a microstructured polymer optical fiber (mPOF). The bandwidth of the chirped FBG (CFBG) was achieved from 0.11 to 4.86 nm, which corresponds to a tunable dispersion range from 513.6 to 11.15 ps/nm. Furthermore, thermal sensitivity is used to compensate for the wavelength shift due to the applied strain. These results demonstrate that a CFBG in a POF is a promising technology for future optical systems. (C) 2018 Optical Society of AmericaFundacao para a Ciencia e a Tecnologia (FCT) (SFRH/BPD/109458/2015, UID/EEA/50008/2013); Research Excellence Award Programme GVA (PROMETEO 2017/103); Oak Ridge Associated Universities (ORAU) (LIFESTART (2017-2019)); Natural Science Foundation of Heilongjiang Province (F2018026).Min, R.; Korganbayev, S.; Molardi, C.; Broadway, C.; Hu, X.; Caucheteur, C.; Bang, O.... (2018). Largely tunable dispersion chirped polymer FBG. 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Analysis of cavitation artifacts in Magnetic Resonance Imaging Thermometry during laser ablation monitoring

: Magnetic Resonance Thermometry Imaging (MRTI) holds great potential in laser ablation (LA) monitoring. It provides the real-time multidimensional visualization of the treatment effect inside the body, thus enabling accurate intraoperative prediction of the thermal damage induced. Despite its great potential., thermal maps obtained with MRTI may be affected by numerous artifacts. Among the sources of error producing artifacts in the images., the cavitation phenomena which could occur in the tissue during LA induces dipole-structured artifacts. In this work., an analysis of the cavitation artifacts occurring during LA in a gelatin phantom in terms of symmetry in space and symmetry of temperature values was performed. Results of 2 Wand 4 W laser power were compared finding higher symmetry for the 2 W case in terms of both dimensions of artifact-lobes and difference in temperature values extracted in specular pixels in the image. This preliminary investigation of artifact features may provide a step forward in the identification of the best strategy to correct and avoid artifact occurrence during thermal therapy monitoring. Clinical Relevance- This work presents an analysis of cavitation artifacts in MRTI from LA which must be corrected to avoid error in the prediction of thermal damage during LA monitoring