The Grizzly, February 12, 2015

UC Partners With Community College • Fongs to Receive Honorary Degrees • Merit Scholarships Increase Because of Higher Tuition • Changes to Title IX Brought Changes to Sexual Assault Documentation • Being an International Student is Difficult but Gratifying for Zhu • Getting to Know Mr. Wismer • Aux./Vox. Prints • Novelist Shares Her Story • Opinion: Main Street is a Growing Concern for Students; Are Ursinus\u27 Policies Against Weed Practical? • Junior Swimmer Stepping Up for the Men • Freshman Swimmin\u27 Women Playing Key Role in Championship Defensehttps://digitalcommons.ursinus.edu/grizzlynews/1923/thumbnail.jp

The Grizzly, October 6, 2016

How do UC Disability? • Ursinus\u27 Student Radio Renaissance • Get Ready to Vote, Ursinus! • Students Adjust to Philly Experience • CSCG Speaker Dissects Affordable Care Act • Schroeder Takes Love for American Studies Abroad • An Electronic Spin on Music • Opinion: Use Your Vote and Use it Wisely This November; Here\u27s What it\u27s Like to be a Republican at UC • Life of a Student Athlete at Ursinus: From Practice to Class • Kicking it Into Overdrivehttps://digitalcommons.ursinus.edu/grizzlynews/1651/thumbnail.jp

Peripheral Nerve Reconstruction Using Enriched Chitosan Conduits

The repair of peripheral nerve traumatic lesions still represents a major cause of permanent motor and sensory impairment. In case of substance loss, a nerve guide should be used to bridge the proximal with the distal stump of the severed nerve. The effectiveness of hollow nerve guides is limited by the delay of axonal growth due to the absence of a regeneration substrate inside the conduit. To fasten up nerve regeneration, nerve guides should thus be enriched by a luminal filler. In this study, we investigated, in a 12-mm rat sciatic nerve defect experimental model, the effectiveness of chitosan-based conduits of different acetylation filled either with a hyaluronic acid gel (NVR gel) or with a magnetic fibrin hydrogel, in comparison with traditional autografts. Results showed that all types of artificial nerve conduits led to functional recovery not significantly different from autografts. By contrast, morphological and morphometrical analyses showed that the best results among nerve guides were found in medium degree of acetylation (DAII: ∼5%) chitosan conduits enriched with the NVR gel

Effect of Local Delivery of GDNF Conjugated Iron Oxide Nanoparticles on Nerve Regeneration along Long Chitosan Nerve Guide

Local delivery of neurotrophic factors is a pillar of neural repair strategies in the peripheral nervous system. The main disadvantage of the free growth factors is their short half‐life of few minutes. In previous studies, it was demonstrated that conjugation of various neurotrophic factors to iron oxide nanoparticles (IONP) led to stabilization of the growth factors and to the extension of their biological activity compared to the free factors. In vitro studies performed on organotypic dorsal root ganglion (DRG) cultures seeded in NVR gel (composed mainly of hyaluronic acid and laminin) revealed that the glial cell–derived neurotrophic factor (GDNF) conjugated to IONP‐enhanced early nerve fiber sprouting and accelerated the onset and progression of myelin significantly earlier than the free GDNF and other free and conjugated factors. The present article summarizes results of in vivo study, aimed to test the effect of free versus conjugated GDNF on regeneration of the rat sciatic nerve after a severe segment loss. We confirmed that nerve device enriched with a matrix with GDNF gives more successful results in term of regeneration and functional recovery in respect to the hollow tube; moreover, there are no detectable differences between free versus conjugated GDNF

The Lantern, 2016-2017

• Our Lady of Perpetual Virginity • Essential Terms for the Audience • Stories Untold • Jesus Camp • The Second Avenue Schmear • Driving to the Beach • Thanks, Alice • Decay • Peanut Butter Rhapsody • Transactions • Traffic • Sissy • Melting Wings • Ocean • Small Town Summer • Third Story • Family Trees • Mixed, Just Like Me • Sour Graves • How Sweet the Sound • Goodnight, Halfmoon • I\u27m Going to Ask Him How • Music • Pizza • Manhoodlike • Meditations From a Bunk Bed in a Home on Mount Pocono • Soft • Twilight\u27s Palette • The Oracle • Cynicism • River Ganges • Pinata Body and Hearing the Gun Shot • Song With No Music • Of Mornings Considering Womanhood • 10 Hours in Philadelphia • To Cut • Sachrang • Bavarian Wave Swinger • Irish Rain • Remembrances, Well • The Roses • Buttermilk • The Universe Will Always Listen if You Ask Her, Which is Why I Like Her More Than God • A Lukewarm Light • A Thought of Death • Hobson • Decaying Light • Window Women • Dead Bee • The Imagery • For Rent • Mona Lisa MMXVIhttps://digitalcommons.ursinus.edu/lantern/1185/thumbnail.jp

The Lantern, 2014-2015

• The Retreat • Part of Eve\u27s Discussion • Buchanan • Hypotheticals • The Baby Hippo • Sertraline and Cheerios • Margins • Anatomy of Me • Orange • Ode to Mathematics • Garden Path • Periphery • 10n Power=Our Maybe Domains • Hillside • Baltimore//Analogues • Work is a Religion • At the Bridal Shower • November • Revisionist History • Cold Front • Lung (for D. Avitabile) • Tether • Hold Still • Reverb • An Almost English Major and His Daughter • Clocks • In the Kitchen on a Sunday Afternoon • Amy • Nine • Customary Thoughts • Showers • Te Encuentro • I Find You • Literary Analysis • The Diamond on My Face • Catherine • Hunsberger Woods, 11:42 on a School Night • Cabbage • After Class • For Chell • To Whom It May Concern • Contra • Shards • Smoke and Roses • Polaroid • Spring\u27s Debut • The Deadline • A Previous Life • Wet Canvas • Obsessions and Compulsions • For Xandra • The Seagulls of 17th Street • No Man\u27s Land • Summer Flowers • Float • Dana Reads • A Barcelona Moment • Business Meeting • Posted • Champagnehttps://digitalcommons.ursinus.edu/lantern/1181/thumbnail.jp

The Lantern, 2013-2014

• Strikes • Pietro di Venezia • To the Lover of Small Things • Jim\u27s Big Day • Akademiks • Redamancy • A Love Poem for Arctia Caja • Mother River • The Lyrics to Your Song • Nerves • Gemini Season • White Interface • The Last Time I Played with Dolls • The Mechanic • My Goldfish • Put Down Your Hammer • Strip • Hollywood • Identity • The Grey Zone • Sophia • When I Became a Poet • Unbroken • The Veteran Aeronaut • I Have Running Water but They had the Stars • Not A Nigga • Mother, Adam, Eve • From Fragile Seeds: A Palindrome • Conspiring, The Spires • Finally Working Out What Goes Where (God, For Example, is in His Kingdom) • Identity Crisis • Affection • Patience • An Enchanting Lost Cause • False Starts • Soggy Rice, Lukewarm Water • The Glow • Heat • 9-14 • Filigree • Diane Arbus • Touched • Dying Alive • Just Another Drunkard on the Train • Dinner • The French Legionnaire • Conspiracy and Theory • 1249am • Colored Pencils • Sea Glass • Roundtrip • The Muse Heard Music • Lacrimosa • The Allegory of the Maze • The Stars on Stuart Road • To Isabella • For Want of a Potato Chip • Termite Nests • Saving a Rose • Today and Yesterday • A Foggy New York • Cat; Wurtzburg • Embrace • Faces • Geisha • Pacis Leo • Patterns • Te-Whanganui-a-Tara (The Dock)https://digitalcommons.ursinus.edu/lantern/1180/thumbnail.jp

The Lantern, 2015-2016

• Ghosts • Going to China • 98% Guaranteed • Constellation/Boulevard • Prayer • The Little One • Burning • The Amber Macaroon • Becoming • Requiem • Construction Site • Thirteen Ways of Looking at a Dragon • Charlie • No Sleep • A Lesson in Physical Education • Statues • Who Can Love a Black Woman? • Apples • Fun Craft • The Door at Midnight • Eve as a Book in the Bible • Boys • Diamond Heart • To Apollo • Joanne and Her July Garden • Option A, 1936 • Young White Girls, Hollow Bodies, and Home • Mama\u27s Stance on Sugar • The Mariana Trench • Hurricane • Part of the Job • Avenue H Blues • Hour of Nones • Send Toilet Paper • Grave Robbing • Wild Turkey • The Creek • Let\u27s Go for a Walk • Deaconess • Border of Love • Your Father, Rumpelstiltskin • Purchasing Poplars • Red Tatters • Sunken • Whispers • Existence • God Took a Cigarette Break with Police Officers • Martian Standoff • In the Headlights • It\u27s a Subtle Thing • Dear Kent • Hanako-san • A Brief Interlude • On Fencing, Gummy Worms, and my Inescapable Fear of Living in the Moment • Stolen Soul • Block • Mortem Mei Fratris • Kalki • Lake Placid • Atom and Eve • The Baerie Queene • Gladston • Soldiers at Gettysburg • Pattern • Foliage • Mass Media • Arrow • Move Out • Wanderers • Riverside Gardenhttps://digitalcommons.ursinus.edu/lantern/1182/thumbnail.jp

Specific Binding of the Pathogenic Prion Isoform: Development and Characterization of a Humanized Single-Chain Variable Antibody Fragment

Murine monoclonal antibody V5B2 which specifically recognizes the pathogenic form of the prion protein represents a potentially valuable tool in diagnostics or therapy of prion diseases. As murine antibodies elicit immune response in human, only modified forms can be used for therapeutic applications. We humanized a single-chain V5B2 antibody using variable domain resurfacing approach guided by computer modelling. Design based on sequence alignments and computer modelling resulted in a humanized version bearing 13 mutations compared to initial murine scFv. The humanized scFv was expressed in a dedicated bacterial system and purified by metal-affinity chromatography. Unaltered binding affinity to the original antigen was demonstrated by ELISA and maintained binding specificity was proved by Western blotting and immunohistochemistry. Since monoclonal antibodies against prion protein can antagonize prion propagation, humanized scFv specific for the pathogenic form of the prion protein might become a potential therapeutic reagent

Faces Bright With Relief: Creative Nonfiction Essays on Growing Up

I never know how to describe this project. I tell people I’m writing creative nonfiction essays, and hope that’s confusing enough that they don’t question me further. I hate throwing out the word “memoir.” It sounds pretentious. I say “David Sedaris-y type essays,” so people know they’re short, and not stuffy rhapsodies. These essays say who I am, at one time, in one style of writing with one title, and they tell the stories of people as I remember them. The narrator is not exactly me, and the characters are not truly my brother or aunt or whoever. Aren’t memoirs for old people to write? people ask me. My best answer is Sure, but I’ll never be this version of myself again. This project came to me slowly. I don’t remember an exact moment of deciding this was it, I only remember the thought of seeking solace in the retelling of stories, making sense of how I am here and why that is. I have written four creative essays for this project ranging from 10-20 pages each, and am going to write a more academic essay reflecting on my experience and what I learned about memoir. As part of my project I assigned myself memoirs to read: On the Road by Gloria Steinem, Hold Still by Sally Mann, The Light of the World by Elizabeth Alexander, and currently I am reading an anthology of essays edited by Ariel Levy. These books are all very different and each has altered my writing slightly. Above all this project has taught me how to live in the past tangibly, that I love writing endings more than beginnings, and that often it is necessary to make up dialogue