Multimedia reader on the history of foreign music as a means of independent work of students

In this article the actual problem of the use of multimedia reader of foreign music history for the organization of independent work of students. The specificity of the principles of creation and possibilities of this didactic toolВ данной статье рассматривается актуальная проблема применения мультимедийной хрестоматии по истории зарубежной музыки для организации самостоятельной работы студентов. Выявлены специфика, принципы создания и возможности данного дидактического средств

Video as modern training students in the classroom on the subject «History of Russian music»

In this article the actual problem of the use of video in the classroom for discipline «History of Russian music» The specificity of the principles of creation and the possibility of a didactic toolВ данной статье рассматривается актуальная проблема применения видеоролика на занятиях по дисциплине «История отечественной музыки». Выявлены специфика, принципы создания и возможности данного дидактического средств

The Experience of Creating An Educational Film as a Means of Developing the Cognitive Interest of Students at College Music Literature Lessons

В статье рассматриваются опыт создания и возможности использования учебного фильма в целях развития познавательного интереса учащихся в музыкальном коллеже на занятиях по предмету «Музыкальная литература».The article describes the experience of creating the possibility of using an educational film in order to develop the cognitive interest of students in a music college in the classroom on the subject of "Musical Literature"

Multimedia Benefits "Middle Ages" for Lessons in Musical Literature in College

В статье рассматривается содержание и опыт создания мультимедийного пособия по теме «Средневековье» для занятий по музыкальной литературе в колледже.The article discusses the content and experience of creating a multimedia manual on the topic "Middle Ages" for classes in musical literature in college

Public policy in providing information security identity

Presents an analysis of the regulatory framework of information security identity at the international and national levelsПредставлен анализ нормативно-правовой базы обеспечения информационной безопасности личности на международном и федеральном уровня

The Structure of the Potato Virus A Particles Elucidated by Small Angle X-Ray Scattering and Complementary Techniques

Potato virus A (PVA) protein coat contains on its surface partially unstructured N-terminal domain of the viral coat protein (CP), whose structural and functional characteristics are important for understanding the mechanism of plant infection with this virus. In this work, we investigated the properties and the structure of intact PVA and partially trypsinized PVAΔ32 virions using small-angle X-ray scattering (SAXS) and complimentary methods. It was shown that after the removal of 32 N-terminal amino acids of the CP, the virion did not disintegrate and remained compact, but the helical pitch of the CP packing changed. To determine the nature of these changes, we performed ab initio modeling, including the multiphase procedure, with the geometric bodies (helices) and restoration of the PVA structure in solution using available high-resolution structures of the homologous CP from the PVY potyvirus, based on the SAXS data. As a result, for the first time, a low-resolution structure of the filamentous PVA virus, both intact and partially degraded, was elucidated under conditions close to natural. The far-UV circular dichroism spectra of the PVA and PVAΔ32 samples differed significantly in the amplitude and position of the main negative maximum. The extent of thermal denaturation of these samples in the temperature range of 20-55°C was also different. The data of transmission electron microscopy showed that the PVAΔ32 virions were mostly rod-shaped, in contrast to the flexible filamentous particles typical of the intact virus, which correlated well with the SAXS results. In general, structural analysis indicates an importance of the CP N-terminal domain for the vital functions of PVA, which can be used to develop a strategy for combating this plant pathogen

The Cytoplasmic Tail of Influenza A Virus Hemagglutinin and Membrane Lipid Composition Change the Mode of M1 Protein Association with the Lipid Bilayer

Influenza A virus envelope contains lipid molecules of the host cell and three integral viral proteins: major hemagglutinin, neuraminidase, and minor M2 protein. Membrane-associated M1 matrix protein is thought to interact with the lipid bilayer and cytoplasmic domains of integral viral proteins to form infectious virus progeny. We used small-angle X-ray scattering (SAXS) and complementary techniques to analyze the interactions of different components of the viral envelope with M1 matrix protein. Small unilamellar liposomes composed of various mixtures of synthetic or “native” lipids extracted from Influenza A/Puerto Rico/8/34 (H1N1) virions as well as proteoliposomes built from the viral lipids and anchored peptides of integral viral proteins (mainly, hemagglutinin) were incubated with isolated M1 and measured using SAXS. The results imply that M1 interaction with phosphatidylserine leads to condensation of the lipid in the protein-contacting monolayer, thus resulting in formation of lipid tubules. This effect vanishes in the presence of the liquid-ordered (raft-forming) constituents (sphingomyelin and cholesterol) regardless of their proportion in the lipid bilayer. We also detected a specific role of the hemagglutinin anchoring peptides in ordering of viral lipid membrane into the raft-like one. These peptides stimulate the oligomerization of M1 on the membrane to form a viral scaffold for subsequent budding of the virion from the plasma membrane of the infected cell