Quantifying the role of neurons for behavior is a mediation question

Many systems neuroscientists want to understand neurons in terms of mediation; we want to understand how neurons are involved in the causal chain from stimulus to behavior. Unfortunately, most tools are inappropriate for that while our language takes mediation for granted. Here we discuss the contrast between our conceptual drive towards mediation and the difficulty of obtaining meaningful evidence.Comment: 4 pages, 2 figure

Science Concierge: A fast content-based recommendation system for scientific publications

Finding relevant publications is important for scientists who have to cope with exponentially increasing numbers of scholarly material. Algorithms can help with this task as they help for music, movie, and product recommendations. However, we know little about the performance of these algorithms with scholarly material. Here, we develop an algorithm, and an accompanying Python library, that implements a recommendation system based on the content of articles. Design principles are to adapt to new content, provide near-real time suggestions, and be open source. We tested the library on 15K posters from the Society of Neuroscience Conference 2015. Human curated topics are used to cross validate parameters in the algorithm and produce a similarity metric that maximally correlates with human judgments. We show that our algorithm significantly outperformed suggestions based on keywords. The work presented here promises to make the exploration of scholarly material faster and more accurate.Comment: 12 pages, 5 figure

Learning domain-specific causal discovery from time series

Causal discovery (CD) from time-varying data is important in neuroscience, medicine, and machine learning. Techniques for CD encompass randomized experiments, which are generally unbiased but expensive, and algorithms such as Granger causality, conditional-independence-based, structural-equation-based, and score-based methods that are only accurate under strong assumptions made by human designers. However, as demonstrated in other areas of machine learning, human expertise is often not entirely accurate and tends to be outperformed in domains with abundant data. In this study, we examine whether we can enhance domain-specific causal discovery for time series using a data-driven approach. Our findings indicate that this procedure significantly outperforms human-designed, domain-agnostic causal discovery methods, such as Mutual Information, VAR-LiNGAM, and Granger Causality on the MOS 6502 microprocessor, the NetSim fMRI dataset, and the Dream3 gene dataset. We argue that, when feasible, the causality field should consider a supervised approach in which domain-specific CD procedures are learned from extensive datasets with known causal relationships, rather than being designed by human specialists. Our findings promise a new approach toward improving CD in neural and medical data and for the broader machine learning community.Comment: 16 main pages, 7 figures. Accepted by TML