Estimated trial enrollment and duration.

<p>(A) Enrollment in Latvia. (B) Enrollment in the EEA. (C) Enrollment in the whole clinical trial. (D) Trial duration.</p

Clinical trials in rare diseases.

<p>Clinical trials in rare diseases.</p

Characteristics of clinical trials in rare vs. non-rare diseases.

<p>(A) Primary endpoints. (B) Randomization. (C) Masking. (D) Comparators.</p