21 research outputs found
Oxidative stress and inflammatory markers are determinants of carotid artery disease quantified by magnetic resonance imaging
Prediction of Cardiovascular Events and All-Cause Mortality With Erectile Dysfunction A Systematic Review and Meta-Analysis of Cohort Studies
Background-Erectile dysfunction (ED) carries an independent risk for
cardiovascular (CV) events. We conducted a meta-analysis of all
longitudinal studies for determining the ability of ED to predict risk
of clinical events and to dissect factors influencing this ability.
Methods and Results-We conducted a comprehensive search of electronic
databases through July 2012. Longitudinal studies that reported relative
risk (RR) estimates with 95% confidence intervals (CIs) were included.
Of the 14 studies included (92 757 participants; mean follow-up, 6.1
years; 16 articles), 13 (14 articles) reported results on total CV
events (91 831 individuals), 4 on CV mortality (34 761 individuals), 4
on myocardial infarction (35 523 individuals), 6 on cerebrovascular
events (27 689 individuals), and 5 on all-cause mortality (17 869
individuals). The pooled RRs for the above-mentioned end points were
1.44 (95% CI, 1.27-1.63), 1.19 (95% CI, 0.97-1.46), 1.62 (95% CI,
1.34-1.96), 1.39 (95% CI, 1.23-1.57), and 1.25 (95% CI, 1.12-1.39),
respectively, for men with versus without ED. The RR was higher in
intermediate-compared with high-or low-CV-risk populations and with
younger age. The RR for studies that diagnosed ED with the use of a
questionnaire compared with a single question was higher (RR, 1.61; 95%
CI, 1.38-1.86 versus RR, 1.27; 95% CI, 1.18-1.37, respectively;
P=0.006).
Conclusions-ED is associated with increased risk of CV events and
all-cause mortality. RR is higher at younger ages, in intermediate-risk
groups, and when a questionnaire is used instead of a single question.
(Circ Cardiovasc Qual Outcomes. 2013; 6: 99-109.
Association between pneumococcal vaccination and cardiovascular outcomes: a systematic review and meta-analysis of cohort studies
Aims Streptococcus pneumoniae is the most common cause of
community-acquired pneumonia (CAP) and CAP-related mortality in adults.
Pneumococcal vaccination (PV) could protect subjects from cardiovascular
events by reducing pneumonia severity or even preventing it. We sought
to determine the ability of PV to protect from the risk of
cardiovascular events.
Methods and results A comprehensive search of electronic databases was
conducted up to March 2014. Cohort studies that reported relative risk
(RR) estimates with 95% confidence intervals (CI) were included. Eleven
studies were included (332,267 participants, mean follow-up 20.1
months). The pooled RRs for cardiovascular events and cardiovascular
mortality were 0.86 (95% CI: 0.76-0.97) and 0.92 (95% CI: 0.86-0.98;
fixed-effects), respectively, for subjects with PV versus without PV.
Protective ability was more prominent in high cardiovascular risk
populations and with older age. The protective role of PV was attenuated
after 1 year (RR: 0.72; 95% CI: 0.59-0.88 vs RR: 1.03; 95% CI:
0.93-1.14; p=0.002, for follow-up >1 year vs 1 year, respectively). It
also increased as the presence of cardiovascular and pulmonary disease
increased. Regarding myocardial infarction (MI) and cerebrovascular
events, the protective role of PV was statistically significant only in
the elderly (RR: 0.90; 95% CI: 0.817-0.999; fixed-effects and RR: 0.86;
95% CI: 0.75-0.99, respectively).
Conclusion PV is associated with decreased risk of cardiovascular events
and mortality. This protective effect increases at older age and in high
cardiovascular risk subjects and decreases as the time elapses from PV.
PV decreases the risk of MI and cerebrovascular events in the elderly
TCT-744 Does “High” implantation Of Self-Expandable prosthesis Affect Positively Short- And Long-Term Outcome Of Patients Undergoing Transcatheter Aortic Valve Implantation?
HIGHER BASELINE INFLAMMATORY BURDEN IS ASSOCIATED WITH WORSE PROGNOSIS IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE UNDERGOING CORONARY STENTING
Predictors of obstructive coronary artery disease in otherwise `healthy' individuals with ST-segment depression during paroxysms of atrial fibrillation
Left ventricular (LV) geometry and dipping state are determinants of LV mass reduction with angiotensin-converting enzyme inhibitor antihypertensive treatment
Objectives Left ventricular hypertrophy is a major risk predictor in
hypertensive patients and its regression is beneficial in terms of
prognosis. The aim of this observational, open-labeled study was to
investigate the effect of left ventricular geometry and dipping pattern
on left ventricular mass reduction after chronic treatment with
angiotensin-converting enzyme inhibitors, in a large population of
hypertensive patients.
Methods We evaluated untreated patients with mild to moderate essential
hypertension, before and 6 months after treatment with
angiotensin-converting enzyme inhibitor monotherapy or
angiotensin-converting enzyme inhibitor-low-dose thiazide combination.
Left ventricular mass index, relative wall thickness and geometry
pattern were derived from echocardiography. Dipping state was determined
with 24-h ambulatory blood pressure monitoring at enrollment.
Results Overall, left ventricular mass index decrease in the 1400
patients (mean age 52.5 years) who completed the study was 12.9% of
baseline value (P < 0.00001). After adjusting for pretreatment value,
left ventricular mass index reduction was similar with all
angiotensin-converting enzyme inhibitors used [P= NS (not
significant)], but it was higher in nondippers than dippers (14.1 vs.
12.3%, P < 0.0001) and in patients with than without baseline left
ventricular hypertrophy (14.6 vs. 11.3%, P < 0.0001). We observed a
stepwise augmentation of left ventricular mass index decrease with
worsening left ventricular geometry (P < 0.001). In multivariable
analysis, impaired left ventricular geometry and blunted nocturnal blood
pressure fall before treatment were independent predictors of a high
left ventricular mass index reduction after treatment, independent of
blood pressure fall, pretreatment left ventricular mass index, and other
potential confounders.
Conclusion In essential hypertension, left ventricular geometry and
dipping state are independent determinants of left ventricular mass
reduction with angiotensin-converting enzyme inhibitor treatment. All
angiotensin-converting enzyme inhibitors are efficient in decreasing
left ventricular mass
Assessment Of Aortic Wave Reflection In Lean And Obese Women With Polycystic Ovary Syndrome
Relation of habitual cocoa consumption to aortic stiffness and wave reflections, and to central hemodynamics in healthy individuals
The effect of habitual cocoa consumption on arterial stiffness and wave
reflection indexes, as well as on peripheral and central blood pressure,
was assessed in 198 healthy subjects. In conclusion, higher cocoa intake
was an independent determinant of low arterial stiffness and wave
reflection indexes and was also independently associated with
significantly lower central (aortic) pulse pressure. (C) 2007 Elsevier
Inc. All rights reserved